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-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst . 2004;96:879-882. 7. Berenson JR, Hillner BE, Kyle RA, et al. American society of clinical oncology clinical practice guidelines: The role of bisphosphonates in multiple myeloma. J Clin Oncol . 2002;20:3719-3736. 8. Delmas PD. The use of bisphosphonates in the treatment of osteoporosis. Curr Opin Rheumatol . 2005;17:462-466. 9. Medical economics. Physicians’ Desk Reference. 57th ed. Montvale, NJ: Medical Economics

antibody inhibiting osteoclast differentiation, activation, and survival with applicable suppression of bone turnover in patients with multiple myeloma, osteolytic bone disease, and bone metastases from breast and prostate cancer. It is also a useful drug for managing the GCT of bone and one excellent option in metastatic GCT. The long time safety and complications, especially in young female patients, are to be proven. Conclusions. Early diagnosis and accurate management of GCT are mandatory in order to achieve good long-term clinical results. Denosumab treatment

REFERENCES 1. Hatano K, Fujita S, Tsujimoto Y, et al. Rare case of the hyaline vascular type of Castlemans’s disease of the kidney. International Journal of Urology . 2007;14:1098-1100. 2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph-node hyperplasia resembling thymoma. Cancer . 1956;9:822-830. 3. Guthrie PJ, Thomas JV, Peker D, Turkbey B, Rais-Bahrami S. Perivesical unicentric Castleman disease initially suspected to be metastatic prostate cancer. Urol Ann . 2016;8:245-248. 4. Vassos N, Raptis D, Lell M, et al. Intra-abdominal localized

. Ibrahim T, Flamini E, Fabbri L, Serra P, Mercatali L, Ricci R, Sacanna E, Falasconi MC, Casadei R, Galassi R et al. Multidisciplinary approach to the treatment of bone metastases: Osteo-oncology center, a new organizational model. Tumori. 2009; 95:291–297. 6. Bandini M, Pompe RS, Marchioni M, Zaffuto E, Gandaglia G, Fossati N, Cindolo L, Montorsi F, Briganti A, Saad F et al. Improved cancer-specific free survival and overall free survival in contemporary metastatic prostate cancer patients: A population-based study. Int. Urol. Nephrol. 2018; 50:71–78. 7. Plunkett TA

, Costerton JW, Sedghizadeh PP. The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy. Curr Osteoporos Rep . 2010;8:40-48. 11. Solomon DH, Mercer E, Woo SB, Avorn J, Schneeweiss S, Treister N. Defining the epidemiology of bisphosphonate-associated osteonecrosis of the jaw: prior work and current challenges. Osteoporosis International . 2013;24:237-244. 12. Walter C, Al-Nawas B, Grotz KA, et al. Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease

prior to coronary revascularisation? Heart Lung Circ . 2012;21:468-479. 30. Xi L, Rui X, Zhang B, Gao F. MRI tracking stem cells transplantation for coronary heart disease. Pak J Med Sci . 2014;30:899-903. 31. Sterenczak KA, Meier M, Glage S, et al. Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer. BMC Cancer . 2012;12:284. 32. Guenoun J, Koning GA, Doeswijk G, et al. Cationic Gd-DTPA liposomes for highly

electrophoresis. Forensic Sci Int Genet Suppl Ser . 2013;4:e274-e275. 26. Kuner R, Brase JC, Sültmann H, Wuttig D: microRNA biomarkers in body fluids of prostate cancer patients. Methods . 2013;59:132-137. 27. Gilad S, Meiri E, Yogev Y, et al. Serum microRNAs are promising novel biomarkers. PLoS One . 2008;3:1-7. 28. Roth C, Rack B, Müller V, Janni W, Pantel K, Schwarzenbach H. Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res . 2010;12:R90. 29. Guo Z, Maki M, Ding R, Yang Y, Zhang B, Xiong L. Genome

Minho, and supported by the Portuguese Foundation for Science and Technology, the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653). References Ahmad MM. Psychometric evaluation of the Cognitive Appraisal of Health Scale with patients with prostate cancer. J Adv Nurs , 2005; 49(1): 78-86 10.1111/j.1365-2648.2004.03266.x 15610384 Ahmad MM Psychometric evaluation of the Cognitive Appraisal of Health Scale with patients

. The overlap may be explained by the existence of a common myelin epitope in the peripheral nervous system (PNS) and the central nervous system (CNS) that is subjected to immune-mediated self-aggression [ 6 , 12 ]. Cases of GBS triggered by surgery have previously been reported to occur in the first eight weeks after the procedure, especially in patients with a history of neoplastic disease (gastrointestinal carcinoma, blood and skin cancers, prostate cancer, or gynaecological cancer) or a positive history of other autoimmune diseases (Sjögren syndrome, giant

onecarbon metabolism and prostate cancer risk. Am J Clin Nutr, 2006; 84: 929–935 Weinstein SJ Stolzenberg-Solomon R Pietinen P Taylor PR Virtamo J Albanes D Dietary factors of onecarbon metabolism and prostate cancer risk Am J Clin Nutr 2006 84 929 935 Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab , 1998; 64: 169–172 Weisberg I Tran P Christensen B Sibani S Rozen R A second genetic polymorphism in methylenetetrahydrofolate