-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostatecancer. J Natl Cancer Inst . 2004;96:879-882. 7. Berenson JR, Hillner BE, Kyle RA, et al. American society of clinical oncology clinical practice guidelines: The role of bisphosphonates in multiple myeloma. J Clin Oncol . 2002;20:3719-3736. 8. Delmas PD. The use of bisphosphonates in the treatment of osteoporosis. Curr Opin Rheumatol . 2005;17:462-466. 9. Medical economics. Physicians’ Desk Reference. 57th ed. Montvale, NJ: Medical Economics
antibody inhibiting osteoclast differentiation,
activation, and survival with applicable suppression of bone turnover in patients with multiple
myeloma, osteolytic bone disease, and bone metastases from breast and prostatecancer.
It is also a useful drug for managing the GCT of bone and one excellent option in metastatic GCT.
The long time safety and complications, especially in young female patients, are to be proven.
Conclusions. Early diagnosis and accurate management of GCT are mandatory in order to achieve
good long-term clinical results. Denosumab treatment
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