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Metastatic Prostate Cancer with Highest Reported PSA Level

References 1. Grönberg H. Prostate cancer epidemiology. Lancet Lond Engl. 2003;361(9360):859–864. 2. Globocan 2012. Available from: 3. Benoit RM, Naslund MJ. The socioeconomic implications of prostate-specific antigen screening. Urol Clin North Am. 1997;24(2):451–458. 4. Krpina K, Markić D, Rahelić D, Ahel J, Rubinić N, Španjol J. 10-year survival of a patient with metastatic prostate cancer: Case report and literature review. Arch Ital Urol Androl. 2015;87(3):252-3. doi: 10.4081/aiua.2015

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Prostate cancer: an occupational hazard in Romania?

References 1. Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O, Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. European Journal of Cancer. 2018;103:356–87. 2. Taitt H.E. Global Trends and Prostate Cancer: A Review of Incidence, Detection, and Mortality as Influenced by Race, Ethnicity, and Geographic Location. Am J Mens Health.2018;12:1807–23. 3. Center MM, Jemal A, Lortet-Tieulent J, Ward E, Ferlay J, Brawley O, Bray F. International

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Left Supraclavicular Lymphadenopathy as the Only Clinical Presentation of Prostate Cancer: A Case Report

, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European journal of cancer. 2013; 49(6):1374-403. 4. Venable DD, Hastings D, Misra RP. Unusual metastatic patterns of prostate adenocarcinoma. The Journal of urology. 1983; 130(5):980-5. 5. MINTZ ER, SMITH GG. Autopsy findings in 100 cases of prostatic cancer. New England Journal of Medicine. 1934; 211(11):479-87. 6. Flocks RH, Boatman DL. Incidence of head and neck metastases from genito urinary neoplasms

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Multiparametric MRI - local staging of prostate cancer and beyond

Introduction Accurate staging of prostate cancer is essential to inform prognosis and to stratify patients for appropriate management. MRI affords excellent soft tissue differentiation making it the most accurate modality for preoperative local T-staging of prostate cancer. 1 According to European Association of Urology (EAU) guidelines, local staging investigations are only indicated for intermediate and high-risk patient groups. 1 The high accuracy of multiparametric MRI (mpMRI) for detection of index lesions can aid T-staging, and can also identify

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Diagnostic benefits of mindin as a prostate cancer biomarker

Introduction Prostate cancer (PCa) is one the most frequently diagnosed tumours of men and the third most common cause of cancer death of Czech men ( 1 ). Currently, the only biomarker in wide clinical use for the diagnosis and prognosis of prostate cancer is the prostate-specific antigen (PSA). Other markers useful for the diagnostics of prostate cancer are free PSA and Free/Total PSA ratio, complexed PSA, pro PSA - 2proPSA and Prostate Health Index (PHI). Total PSA, % fPSA, f/tPSA, and other PSA derivatives, PSAD, PSA velocity, PSADT, age-specific PSA do

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Current status and new approaches in prostate cancer diagnosis

REFERENCES 1. Witold A. Zatoński, U. Sulkowska, J. Didkowska. Kilka uwag o epidemiologii nowotworów w Polsce. Nowotwory. J Oncol. 2015;65(3):179-96. 2. Adams J. The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the lumbar region and in the pelvis. Lancet. 1853;1:393. 3. Nelen V. Epidemiology of prostate cancer. In: J. Ramon, L. J. Denis (eds). Prostate cancer. Recent results in cancer research. Springer, Berlin, Heidelberg; 2007. p. 175. 4. Pienta KJ, Esper PS. Risk factors for prostate

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Obesity is Associated with Upgrading in Prostate Cancers

REFERENCES 1. Allott EH, Masko EM, Freedland SJ. Obesity and Prostate Cancer: Weighing the Evidence. European Urology 2013;63:800-9. 2. Altay B, Erkurt B, Guzelburc V, et al. Impact of obesity on functional and oncological outcomes in radical perineal prostatectomy. CUAJ 2015;9:766-9. 3. Gbenou MCG, Peltier A, Schulman CC, et al. Increased body mass index as a risk factor in localized prostate cancer treated by radical prostatectomy. Urol Oncol 2016;34(6):254.e1-6. 4. Jayachandran J, Aronson WJ, Terris MK, et al. Obesity and positive

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Repeat transrectal prostate biopsies in diagnosing prostate cancer

References 1. Yanke BV, Gonen M, Scardino PT, Kattan MW. Validation of a nomogram for predicting positive repeat biopsy for prostate cancer. J Urol 2005;173:421-4. 2. Smilov N, Mladenov D. Repeated prostate biopsy in patients with continuous suspicion for present prostate carcinoma. Urology 2011;17:6-13. 3. Rodriguez LV, Terris MK. Risks and complications of transrectal ultrasound guided prostate needle biopsy: a prospective study and review of the literature. J Urol 1998;160:2115-20. 4

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The Role of Prostate-Specific Antigen in Prostate Cancer Screening

References 1. Gretzer MB, Partin AW. Chapter 93. Prostate cancer tumor markers. In: Wein AJ, ed. Campbell-Walsh Urology. 9th ed. Philadelphia, PA: Saunders; 2007;2896-906. 2. Watt KW, Lee PJ, M’Timkulu T, Chan WP, Loor R. Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc Natl Acad Sci U S A. 1986 May;83(10):3166-70. DOI: 10.1073/ pnas.83.10.3166 3. Lilja H, Laurell CB. The predominant protein in human seminal coagulate. Scand J Clin Lab Invest. 1985 Nov;45

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The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients

Introduction Conventional clinical parameters alone are inadequate for differentiating indolent and aggressive prostate cancer. Therefore, molecular biomarkers are needed to better define prognosis of prostate cancer patients. Neuroendocrine markers could be used to detect particularly aggressive variants of prostate cancer. Typical markers used to identify neuroendocrine differentiation (NED) in tumor tissue are neuron specific enolase (NSE), chromogranin A (CgA) and synaptophysin (Syp). 1 - 3 Neuroendocrine differentiation, measured by one or more of

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