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Lesch-Nyhan disease: A rare disorder with many unresolved aspects

striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease J Neurochem 1999 72 1 225 – 9 62 Nyhan WL. Dopamine function in Lesch–Nyhan disease. Environ Health Perspect. 2000;108(Suppl 3):409–11. https://doi.org/10.1289/ehp.00108s3409 Nyhan WL. Dopamine function in Lesch–Nyhan disease Environ Health Perspect 2000 108 Suppl 3 409 – 11 https://doi.org/10.1289/ehp.00108s3409 63 Smith DW, Friedmann T. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice

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