Joanna Skulimowska, Paweł Turowski, Edyta Klimczak-Jajor, Marzena Dębska, Katarzyna Guz and Ewa Brojer
Śródziemnego, na Bliskim Wschodzie, w południowowschodniej Azji oraz w Indiach. Wraz z migracją ludności występowanie talasemii alfa zwiększyło swój zasięg do innych obszarów świata, w tym także Polski [ 1 , 2 ].
W przypadku stwierdzenia różnego stopnia mikrocytozy oraz hipochromii, przy prawidłowej gospodarce żelaza u pacjenta podejrzewa się talasemię. Badania biochemiczne, takie jak rozdział frakcji hemoglobin metodą jonowymiennej wysokociśnieniowej chromatografii cieczowej ( ion-exchange high-performance liquid chromatography – HPLC) lub elektroforeza kapilarna
Marta Masternak, Joanna Knap and Krzysztof Giannopoulos
a low MPV/PC ratio was an independent unfavorable predictive factor for OS [ 20 ]. Furthermore, in locally advanced (stage IIIA/B) inoperable NSCLC MPV, as well as PLT and ECOG performance score were found as the most significant independent factors affecting survival ( p < 0.001, p = 0.008, and, p = 0.034, respectively) [ 21 ]. Whereas, in epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma, the MPV level not only influence prognosis but also predict the outcome of EGFR tyrosine kinase inhibitor (TKI) therapy. In this type of cancer, high MPV
Amina H Hassab, Dalia A Nafea, Rania S Swelem and Basma M Ghazal
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues, with maturation arrest of cells in the bone marrow and impaired production of normal blood cells [ 1 , 2 ].
Treatment strategies of patients with AML are based on various prognostic factors, including age and performance status of the patient, as well as cytogenetic and molecular characteristics of the leukemic clone [ 3 ].
To date, cytogenetic
Monika Długosz-Danecka, Michał Szymczyk, Joanna Fischer, Anna Łojko-Dankowska, Justyna Rybka, Joanna Mańko, Katarzyna Duda and Wojciech Jurczak
histopathological assessment of tissue samples excised before the first-line therapy [ 15 ]. At baseline staging according to Ann Arbor classification, Eastern Cooperative Oncology Group performance status (ECOG PS) and International Prognostic Index (IPI) were assessed.
Patients received nivolumab intravenously over 60 minutes at 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity. Efficacy data including overall response rate (ORR), complete remission (CR) rate, progression-free survival (PFS) and overall survival (OS) as well as the safety data were
Agnieszka Szymczyk, Aleksandra Nowaczyńska, Maciej Korpysz, Helena Donica, Agnieszka Bojarska-Junak, Monika Długosz-Danecka, Waldemar Tomczak, Ewa Wąsik-Szczepanek and Iwona Hus
. Clin Chem Lab Med 2016;54:1073–83.
Barnidge DR Dispenzieri A Merlini G et al Monitoring free light chains in serum using mass spectrometry Clin Chem Lab Med 2016 54 1073 – 83
 Hansen CT. Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation. Clin Chem Lab Med 2016;54:1031–3.
Hansen CT Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation Clin Chem Lab Med 2016 54
;4:121– 8. 22662297 10.4055/cios.2012.4.2.121
Kamath AF Horneff JG Forsyth A Nikci V Nelson CL Total knee arthroplasty in hemophiliacs: gains in range of motion realized beyond twelve months postoperatively Clin Orthop Surg 2012 4 121 8
 Vallejo L, Pardo A, Gomis M, Gallach JE, Pérez S, Querol F. Influence of aquatic training on the motor performance of patients with haemophilic arthropathy. Haemophilia 2010;161:155–61.
Vallejo L Pardo A Gomis M Gallach JE Pérez S Querol F Influence of aquatic training on the
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by abnormal proliferation of progenitor cells. Age is a fundamental risk factor, with median overall survival (OS) < 6 months for elderly patients with AML receiving intensive therapy [ 1 ]. Several measurable and immeasurable factors, including poor performance status, adverse cytogenetics, genetic mutations, and complications, are responsible for poor prognosis [ 2 , 3 , 4 , 5 ].
DNA methylation has been demonstrated to silence tumor suppressor
and TTH was determined to be 0.037, and the sensitivity was 92.5% and specificity was 55% for this value.
Primary headaches comprise a health problem that causes the loss of capacity and performance. For this reason, accurate diagnosis and administration of suitable treatment is important. Since the diagnosis of migraine and other primary headaches depends only on the medical history obtained from the patient, clinicians have a hard time and, sometimes, they may apply the wrong treatment. TTH is the most common headache around the world; however, different
Edyta Klimczak-Jajor, Joanna Skulimowska, Anna Ejduk, Katarzyna Guz, Małgorzata Uhrynowska and Ewa Brojer
origin [ 7 ]. It was also detected in a British patient [ 8 ], an Iran patient [ 3 ] and an inhabitant of the Netherlands [ 9 ]. In HPLC (high-performance liquid chromatography) analysis as well as in other routine laboratory methods the hemoglobin coded by DNA with this mutation, can be mistaken with HbS since both elute in the “S” window compartment [ 10 ].
The aim of this communication is to highlight the occurrence of compound hetreozygotes in α-globin gene defects in Northern Europe.
Materials and methods
A 32-year-old Polish woman was diagnosed for red
Teresa Iwaniec, Joanna Zdziarska and Artur Jurczyszyn
assays does not always reflect the real coagulation status in vivo. Coagulation disturbances, however, tend to increase with the progress of the disease [ 25 ].
Authors’ contributions/ Wkład autorów
TI – performance of laboratory tests, data analysis, writing the manuscript.
JZ – clinical assessment of the patient, reviewing the manuscript.
AJ – clinical assessment of the patient, data analysis, reviewing the manuscript.
Conflict of interest
Conflict of interest/ Konflikt interesu: We declare no conflict of interest