Mehrnoosh Zakerkish, Davood Raeisi, Shahram Rafie, Mohammad Jafar Shaterzadeh Yazdi, Zahra Kosarian, Shirin Rahimzadeh Telegrafchi and Saeed Hesam
Background and aims: Diabetic peripheral neuropathic pain (DPNP) is one of the most common complications of diabetes and is difficult to treat. Existing treatments are often inadequate at controlling pain and limited by side-effects and drug tolerance. This study assessed the efficacy of nortriptyline versus Transcutaneous Electrical Nerve Stimulation (TENS) in patients with DPNP.
Material and method: This is a randomized clinical trial study conducted on 39 patients with DPNP referring to Golestan Hospital in Ahvaz in 2017. Patients were randomly treated with TENS (18 sessions, each session 30 minutes; n=20) or nortriptyline (25 to 75 mg, once daily; n=19) for 6 weeks. Patients were evaluated for side effects and pain relief using visual analog scale (VAS).
Results: There was a significant improvement in pain with both treatments compared with baseline (p˂0.001). The patients in nortriptyline group experienced more pain relief (7.21±1.51 to 0.84±1.34) than the TENS group (7.6±1.47 to 2.75 ±2.43) (P=0.001). The 50% pain relief was observed in 14 patients (73%) in nortriptyline group, 6 patients (30%) in TENS group. Moreover, the side effects were seen in 15% of TENS and 55% of patients in nortriptyline groups (P=0.019).
Conclusion: Both TENS and nortriptyline were effective and safe in the management of DPNP. But nortriptyline showed a better performance on pain relief.
Luca Coppeta, Luca Di Giampaolo, Stefano Rizza, Ottavia Balbi, Savino Baldi, Antonio Pietroiusti and Andrea Magrini
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Fatourechi V. Upper limit of normal serum thyroid-stimulating hormone: a moving and now an aging target? J Clin Endocrinol Metab 92, 4560
Joanna Skulimowska, Paweł Turowski, Edyta Klimczak-Jajor, Marzena Dębska, Katarzyna Guz and Ewa Brojer
Śródziemnego, na Bliskim Wschodzie, w południowowschodniej Azji oraz w Indiach. Wraz z migracją ludności występowanie talasemii alfa zwiększyło swój zasięg do innych obszarów świata, w tym także Polski [ 1 , 2 ].
W przypadku stwierdzenia różnego stopnia mikrocytozy oraz hipochromii, przy prawidłowej gospodarce żelaza u pacjenta podejrzewa się talasemię. Badania biochemiczne, takie jak rozdział frakcji hemoglobin metodą jonowymiennej wysokociśnieniowej chromatografii cieczowej ( ion-exchange high-performance liquid chromatography – HPLC) lub elektroforeza kapilarna
Marta Masternak, Joanna Knap and Krzysztof Giannopoulos
a low MPV/PC ratio was an independent unfavorable predictive factor for OS [ 20 ]. Furthermore, in locally advanced (stage IIIA/B) inoperable NSCLC MPV, as well as PLT and ECOG performance score were found as the most significant independent factors affecting survival ( p < 0.001, p = 0.008, and, p = 0.034, respectively) [ 21 ]. Whereas, in epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma, the MPV level not only influence prognosis but also predict the outcome of EGFR tyrosine kinase inhibitor (TKI) therapy. In this type of cancer, high MPV
Jaspreet Kaur, Shailendra Kumar Singh and Jaspreet Singh Vij
Background and Aims: diabetes mellitus one of the non-communicable disorders which is spreading globally irrespective of nation being developed or developing. The aim of this study was to optimize the exercise protocols and to find the efficacy of these protocols on glucose control, balance, gait and proprioception in patients suffering from type 2 diabetes mellitus.
Material and Methods: 40 individuals with type 2 DM with age 35 to 60 were randomly allotted to four groups with 10 subjects in each. Cycle ergometer based aerobic exercises were given with duration of 20 or 30 minutes twice or thrice weekly for 6 weeks. Pre and post intervention was collected using Fullerton Advanced Balance scale for balance, spatiotemporal gait parameters for gait, Continuous passive motion for Proprioception and High Performance Liquid Chromatography in the laboratory.
Results: data was analysed using Design Expert software. Full factorial design was used to compare role of duration and frequency of exercise on each patient. The results showed significant effect of exercises on balance, gait, proprioception and glycated haemoglobin (HbA1c).
Conclusion: Aerobic exercises if given for 30 minutes and thrice weekly can show a significant improvement in complications in Diabetics.
Sorina Maria Aurelian, Ana Capisizu, Andreea Zamfirescu and Dan Cheţa
With age, arteries become more rigid and pulse waves propagate faster. The pathogenic mechanisms that causes vascular stiffness in type 2 diabetes are complex but incompletely understood. An important element in the development of this phenomenon appears to be insulin resistance. One of the first line health problems that persist in the present is the failure to detect cardiovascular diseases in the preclinical stage which is important since more frequent cardiac events (myocardial infarction, sudden death) occur in people without obvious cardiovascular pathology in the medical history. One of the degenerative diseases with the greatest impact on the autonomy is dementia of elderly people. Recent studies have shown the association and even the possible involvement of cardiovascular risk factors and arterial stiffness in the pathogenesis of dementia and cognitive impairment. Although pulse wave velocity in the aorta is related to subclinical coronary atherosclerosis (being an important biomarker of cardiovascular risk in asymptomatic individuals), arterial stiffness is also a predictor of cognitive performance, cognitive decline or dementia.
Nidhi Takkar, Jai Prakash Takkar, R Padmakumar, Navin A Patil, Karthik N Rao and Dipanjan Bhattacharje
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Raluca-Iulia Juncar, Mihai Juncar, Florin-Onişor Gligor and Amorin-Remus Popa
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Rucsandra Dănciulescu Miulescu, Denisa Margină, Anca Ungurianu, Roxana Irina Roșca, Alina Nicolau and Andrada Doina Mihai
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Viviana Elian, Cristian Panaite, Dan Cheta and Cristian Serafinceanu
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