Duangporn Thong-Ngam, Maneerat Chayanupatkul and Vikit Kittisupamongkon
. 2004; 363: 157-63.
13. Sternfeld B, Ngo L, Tager IB. Associations of body composition with physical performance and selfreported functional limitation in elderly men and women. Am J Epidemiol. 2002; 156:110-21.
14. Larsson UE. Influence of weight loss on pain, perceived disability and observed functional limitations in obese women. Int J Obes Relat Disord. 2004; 28:269-77.
15. Jensen GL, Roy MA, Buchanan AE, Berg MB. Weight loss intervention for obese older women: improvements in performance and function. Obes Res. 2004
Sang-Hyeok Seo, Seung-Hyun Kwak, Soon-Cheol Chung, Hyung-Sik Kim and Byung-Chan Min
or navigation system increases driver workload and influences the stress experienced by the driver. Such distractions activate the sympathetic nervous system and increase the heart rate and skin conductance level (SCL) of drivers [ 15 , 16 , 17 , 18 , 19 ].
Driving performance is influenced by a combination of human, vehicular, and environmental factors. Because of a flaw in one or more of these factors, accidents occur wherein the main cause is most often the human factor [ 20 ]. Accidents because of human factors occur when the driver is inexperienced or
Paula Antonoaea, Anca Gabriela Cârje, Adriana Ciurba, Nicoleta Todoran, Alexandru Robert Vlad and Daniela Lucia Muntean
Objective: The aim of this study was to develop and validate two HPLC methods for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems.
Methods: Based on 1.0% hydroxypropyl methylcellulose 15000, transdermal patches containing meloxicam or tenoxicam were prepared by solvent evaporation technique. Analytical performances of the HPLC methods for the quantification of meloxicam and tenoxicam from such systems were assessed in terms of specificity, linearity, detection limit, quantification limit, recovery and precision.
Results and discussion: The linearity of the method was assessed through a calibration curve in the 1.0 - 75.0 μg∙mL−1 concentration range, with a regression coefficient higher than 0.999. The detection limit and the quantification limit were found to be 0.46 μg∙mL−1 and 1.39 μg∙mL−1, for meloxicam; and 0.88 μg∙mL−1, respectively 2.64 μg∙mL−1 for tenoxicam. According to the European Pharmacopeia 5.0 the mean recovery was found to be between 75% and 125%. As performance criteria for precision was used the RSD% which were lower than 2.0% for both methods.
Conclusions: The proposed liquid chromatography methods provide selective, linear and precise results for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems. The presence of a single peak in the chromatograms of the analyzed transdermal patches with meloxicam or tenoxicam, certify the successful determination of the active pharmaceutical ingredient in the prepared patches.
8. Terry S, Teitelbaum Z. Determination of pyridostigmine in human plasma by high-performance liquid chromatography. J Liq Chromatogr and Rel Techol. 1991; 14:3745-54.
9. Yakatan GJ, Tien JY. Quantitation of pyridostigmine in plasma using high-performance liquid chromatography. J Chromatogr. 1979; 164:399-403.
10. Ellin RI, Zvirblis P, Wilson MR. Method for isolation and determination of pyridostigmine and metabolites in urine and blood. J Chromatogr. 1982; 228:235-44.
11. Michaelis HC
Pappas M. Efthymios, Mpournaka Spiridoula, Katopodis Periklis, Chardalias Andreas, Tsakas Sotiris, Eleftheriadis Theodoros, Papachristou Evangelos, Katopodis P. Konstantinos and Goumenos S. Dimitrios
Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, immune deficiency also exists in CKD patients. The number and the activity of Natural Killer cells (NK-cells) are influenced by the biocompatibility of various dialysis membranes. In this study we investigated the effect of dialysis modality and membrane type on NK-cell number and on phagocytic activity of neutrophils in patients on different dialysis methods.
Sixty patients were included in the study and divided in three groups of 20 patients each. Patients on conventional hemodialysis using Low Flux membrane (cHD-LF) were included in Group I, patients on conventional dialysis using High Flux membrane (cHD-HF) were included in Group II and patients treated by on-line hemodiafiltration with High Flux polysulphone membrane (on-line HDF) were included in Group III. Native immunity was investigated using the number of NK-cells and the phagocytic activity of neutrophils.
NK-cells count was significantly lower (p<0.001) in the three groups of dialyzed patients in comparison to healthy subjects. However, no significant difference was observed in the NK-cells count among patients treated by conventional dialysis using Low or High Flux membrane and patients treated by on-line hemodiafiltration. Similarly, although the phagocytic activity of neutrophils was significantly decreased in all patients on dialysis (p<0.001), no difference related to the dialysis modality or membrane performance was observed. A strong positive correlation was recognized between parathormone blood levels and number of NK-cells (r=0.305, p<0.01).
In conclusion, an impairment of the native immunity represented by NK cell number and phagocytic activity of neutrophils is observed in patients on dialysis. Dialysis modality and membrane performance do not influence the native immunity of dialyzed patients. However, parathormone blood levels are possibly involved in the development of immune system disturbances in such patients.
Thomas Friedli, Peter M. Villiger and Brigitte E. Gantschnig
Search Terms nach Datenbank (am Bsp. MeSH)
test , outcome , evaluation tool , scale , iInventory , measure
outcome , outcome assessment , tests , evaluation tool , scale , inventory , measure
ability to work
employment , work performance , return to work , labor force , occupational status , back to work , occupation , vocation , ability to work , working ability , capacity to work , work capacity
Mariela P. Tsanova, Neshka A. Manchorova-Veleva, Nonka G. Mateva and Snejana Ts. Tsanova
1. Zochbauer H. Number of dental restorations worldwide. Mark Res Ivoclar Vivadent 2011.
2. Burke FJ, Wilson NH, Cheung SW, et al. Influence of patient factors on age of restorations at failure and reasons for their placement and replacement. J Dent 2001;29:317-24.
3. Heintze SD, Rousson V. Clinical effectiveness of direct class II restorations – a meta-analysis. J Adhes Dent 2012;14:407-31.
4. Fasbinder DJ. Clinical performance of chair-side CAD/CAM restorations. J Am Dent Assoc 2006;137:22-31.
5. Fasbinder D. Using
supervised-learning model review, Fuhr et al. (2015) showed the classification models which have been used in the past to classify infant cries and evaluated the applicability of these classification models. Hence, computer-based algorithms were suited to classify infant cries. But considering the performance of machines in the field of language detection, the human abilities were much better than the machine-based abilities on language and speech identification ( Norvig, 2012 ; Luxton, 2016 ).
Studies investigating the association of specific cry characteristics to
Hannes Außermaier, Ursula Margarethe Costa, Maria Essmeister and Gudrun Diermayr
den transkribierten Wortmeldungen der Rollstuhlnutzer/-innen wurden zunächst induktiv Kodes für genannte Barrieren gebildet ( Elo & Kyngäs, 2008 ). Mit Hilfe eines handlungs- und partizipationsorientierten Modells, des Occupational Performance Model (Australia) (OPM(A)) ( Ranka & Chapparo, 1997 ), wurden die Barrieren in einem weiteren deduktiven Schritt den jeweiligen Umwelten (physikalisch, sensorisch, kulturell und sozial) zugeordnet; die Barrieren der physikalischen Umwelt wurden im Detail weiter analysiert und dem multiprofessionellen Projektteam für die
Milica Stanković, Vesna Savić and Valentina Marinković
. Wang SM, Bu SS, Liu HM, Li HY, Liu W, Wang YD. Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/ electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2009; 23: 899-906. http://dx.doi.org/10.1002/rcm.3935PMid:19222030
10. Cho SH, Im HT, Park WS, Ha YH, Choi YW, Lee KT. Simple method for the assay of clindamycin in human plasma by reversed-phase high-performance liquid chromatography with UV detector. Biomed Chromatogr 2005; 19: 783-7. http://dx.doi.org/10.1002/bmc.517