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Body mass index and percentage of body fat determined physical performance in healthy personnel

. 2004; 363: 157-63. 13. Sternfeld B, Ngo L, Tager IB. Associations of body composition with physical performance and selfreported functional limitation in elderly men and women. Am J Epidemiol. 2002; 156:110-21. 14. Larsson UE. Influence of weight loss on pain, perceived disability and observed functional limitations in obese women. Int J Obes Relat Disord. 2004; 28:269-77. 15. Jensen GL, Roy MA, Buchanan AE, Berg MB. Weight loss intervention for obese older women: improvements in performance and function. Obes Res. 2004

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Effect of distraction task on driving performance of experienced taxi drivers

or navigation system increases driver workload and influences the stress experienced by the driver. Such distractions activate the sympathetic nervous system and increase the heart rate and skin conductance level (SCL) of drivers [ 15 , 16 , 17 , 18 , 19 ]. Driving performance is influenced by a combination of human, vehicular, and environmental factors. Because of a flaw in one or more of these factors, accidents occur wherein the main cause is most often the human factor [ 20 ]. Accidents because of human factors occur when the driver is inexperienced or

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Validation of High Performance Liquid Chromatography Methods for Determination of Meloxicam and Tenoxicam from Transdermal Therapeutic Systems

Abstract

Objective: The aim of this study was to develop and validate two HPLC methods for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems.

Methods: Based on 1.0% hydroxypropyl methylcellulose 15000, transdermal patches containing meloxicam or tenoxicam were prepared by solvent evaporation technique. Analytical performances of the HPLC methods for the quantification of meloxicam and tenoxicam from such systems were assessed in terms of specificity, linearity, detection limit, quantification limit, recovery and precision.

Results and discussion: The linearity of the method was assessed through a calibration curve in the 1.0 - 75.0 μg∙mL−1 concentration range, with a regression coefficient higher than 0.999. The detection limit and the quantification limit were found to be 0.46 μg∙mL−1 and 1.39 μg∙mL−1, for meloxicam; and 0.88 μg∙mL−1, respectively 2.64 μg∙mL−1 for tenoxicam. According to the European Pharmacopeia 5.0 the mean recovery was found to be between 75% and 125%. As performance criteria for precision was used the RSD% which were lower than 2.0% for both methods.

Conclusions: The proposed liquid chromatography methods provide selective, linear and precise results for the quantification of meloxicam and tenoxicam from transdermal therapeutic systems. The presence of a single peak in the chromatograms of the analyzed transdermal patches with meloxicam or tenoxicam, certify the successful determination of the active pharmaceutical ingredient in the prepared patches.

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Brief communication (Original). Validation of a high-performance liquid chromatography method for the determination of pyridostigmine in plasma

; 277:231-7. 8. Terry S, Teitelbaum Z. Determination of pyridostigmine in human plasma by high-performance liquid chromatography. J Liq Chromatogr and Rel Techol. 1991; 14:3745-54. 9. Yakatan GJ, Tien JY. Quantitation of pyridostigmine in plasma using high-performance liquid chromatography. J Chromatogr. 1979; 164:399-403. 10. Ellin RI, Zvirblis P, Wilson MR. Method for isolation and determination of pyridostigmine and metabolites in urine and blood. J Chromatogr. 1982; 228:235-44. 11. Michaelis HC

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The Effect of Dialysis Modality and Membrane Performance on Native Immunity in Dialysis Patients

Abstract

Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, immune deficiency also exists in CKD patients. The number and the activity of Natural Killer cells (NK-cells) are influenced by the biocompatibility of various dialysis membranes. In this study we investigated the effect of dialysis modality and membrane type on NK-cell number and on phagocytic activity of neutrophils in patients on different dialysis methods.

Sixty patients were included in the study and divided in three groups of 20 patients each. Patients on conventional hemodialysis using Low Flux membrane (cHD-LF) were included in Group I, patients on conventional dialysis using High Flux membrane (cHD-HF) were included in Group II and patients treated by on-line hemodiafiltration with High Flux polysulphone membrane (on-line HDF) were included in Group III. Native immunity was investigated using the number of NK-cells and the phagocytic activity of neutrophils.

NK-cells count was significantly lower (p<0.001) in the three groups of dialyzed patients in comparison to healthy subjects. However, no significant difference was observed in the NK-cells count among patients treated by conventional dialysis using Low or High Flux membrane and patients treated by on-line hemodiafiltration. Similarly, although the phagocytic activity of neutrophils was significantly decreased in all patients on dialysis (p<0.001), no difference related to the dialysis modality or membrane performance was observed. A strong positive correlation was recognized between parathormone blood levels and number of NK-cells (r=0.305, p<0.01).

In conclusion, an impairment of the native immunity represented by NK cell number and phagocytic activity of neutrophils is observed in patients on dialysis. Dialysis modality and membrane performance do not influence the native immunity of dialyzed patients. However, parathormone blood levels are possibly involved in the development of immune system disturbances in such patients.

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in PRILOZI
Workability for persons with chronic diseases. A systematic review of validity and utility of assessments in German language / Valide und praktikable deutschsprachige Assessments zur Erfassung der Arbeitsfähigkeit bei Menschen mit chronischen Erkrankungen – eine systematische Review

Search Terms nach Datenbank (am Bsp. MeSH) Erfassungsinstrument assessment test , outcome , evaluation tool , scale , iInventory , measure outcome , outcome assessment , tests , evaluation tool , scale , inventory , measure Chronische Erkrankung chronic disease chronic disease Arbeitsfähigkeit ability to work employment , work performance , return to work , labor force , occupational status , back to work , occupation , vocation , ability to work , working ability , capacity to work , work capacity

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Clinical Evaluation of CAD/CAM Indirect Zirconia Restorations of Severely Destroyed Vital Teeth in the Posterior Area – Early Clinical Results

REFERENCES 1. Zochbauer H. Number of dental restorations worldwide. Mark Res Ivoclar Vivadent 2011. 2. Burke FJ, Wilson NH, Cheung SW, et al. Influence of patient factors on age of restorations at failure and reasons for their placement and replacement. J Dent 2001;29:317-24. 3. Heintze SD, Rousson V. Clinical effectiveness of direct class II restorations – a meta-analysis. J Adhes Dent 2012;14:407-31. 4. Fasbinder DJ. Clinical performance of chair-side CAD/CAM restorations. J Am Dent Assoc 2006;137:22-31. 5. Fasbinder D. Using

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Comparison of Supervised-Learning Models and Auditory Discrimination of Infant Cries for the Early Detection of Developmental Disorders / Vergleich von Supervised-Learning Klassifikationsmodellen und menschlicher auditiver Diskriminationsfähigkeit zur Unterscheidung von Säuglingsschreien mit kongenitalen Entwicklungsstörungen

supervised-learning model review, Fuhr et al. (2015) showed the classification models which have been used in the past to classify infant cries and evaluated the applicability of these classification models. Hence, computer-based algorithms were suited to classify infant cries. But considering the performance of machines in the field of language detection, the human abilities were much better than the machine-based abilities on language and speech identification ( Norvig, 2012 ; Luxton, 2016 ). Studies investigating the association of specific cry characteristics to

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Wheelchair users’ perspectives on barriers in public spaces in Vienna: implications for the development of a barrier information system / Barrieren aus der Sicht von Rollstuhlnutzern/-innen im öffentlichen Raum in Wien: Implikationen für ein Barriere-Informationssystem

den transkribierten Wortmeldungen der Rollstuhlnutzer/-innen wurden zunächst induktiv Kodes für genannte Barrieren gebildet ( Elo & Kyngäs, 2008 ). Mit Hilfe eines handlungs- und partizipationsorientierten Modells, des Occupational Performance Model (Australia) (OPM(A)) ( Ranka & Chapparo, 1997 ), wurden die Barrieren in einem weiteren deduktiven Schritt den jeweiligen Umwelten (physikalisch, sensorisch, kulturell und sozial) zugeordnet; die Barrieren der physikalischen Umwelt wurden im Detail weiter analysiert und dem multiprofessionellen Projektteam für die

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Determination of Clindamycin Phosphate in Different Vaginal Gel Formulations by Reverse Phase High Performance Liquid Chromatography

. Wang SM, Bu SS, Liu HM, Li HY, Liu W, Wang YD. Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/ electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 2009; 23: 899-906. http://dx.doi.org/10.1002/rcm.3935PMid:19222030 10. Cho SH, Im HT, Park WS, Ha YH, Choi YW, Lee KT. Simple method for the assay of clindamycin in human plasma by reversed-phase high-performance liquid chromatography with UV detector. Biomed Chromatogr 2005; 19: 783-7. http://dx.doi.org/10.1002/bmc.517

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