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Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer

. Quadeer MA, Lopez R, Wood BG. Does acid suppresive therapy reduce the risk of laryngeal cancer recurrence? Laryngoscope 2005; 115: 1877-81. 8. Copper MP, Smit CF, Stanojcic LD, Devriese PP, Schouwenburg PF Mathus- Vliegen LM. High incidence of laryngeal reflux in patients with head and neck cancer. Laryngoscope 2000; 110: 1007-11. 9. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux Symptom Index (RSI). J Voice 2002; 16: 274-7. 10. Samuels TL, Johnston N. Pepsin as a marker of extraesophageal

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Swallowing disorders after treatment for head and neck cancer

. 23 An interesting finding of the present study is a connection between dysphagia and the symptoms of gastroesophageal reflux. Reflux of gastric acid and pepsin is well-recognized etiologic factor in dysphagia even in subjects without cancer, simply by causing inflammation of the laryngeal and hypopharyngeal mucosa. 24 , 25 Such inflammation can additionally aggravate pre-existing radiomucositis in irradiated patients, leading to scarring and impaired sensitivity of involved mucosa. Reflux to the level above the upper esophageal sphincter was found to impair the

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