Maja Sereg-Bahar, Ales Jerin and Irena Hocevar-Boltezar
. Quadeer MA, Lopez R, Wood BG. Does acid suppresive therapy reduce the risk of laryngeal cancer recurrence? Laryngoscope 2005; 115: 1877-81.
8. Copper MP, Smit CF, Stanojcic LD, Devriese PP, Schouwenburg PF Mathus- Vliegen LM. High incidence of laryngeal reflux in patients with head and neck cancer. Laryngoscope 2000; 110: 1007-11.
9. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux Symptom Index (RSI). J Voice 2002; 16: 274-7.
10. Samuels TL, Johnston N. Pepsin as a marker of extraesophageal
Martina Pezdirec, Primoz Strojan and Irena Hocevar Boltezar
An interesting finding of the present study is a connection between dysphagia and the symptoms of gastroesophageal reflux. Reflux of gastric acid and pepsin is well-recognized etiologic factor in dysphagia even in subjects without cancer, simply by causing inflammation of the laryngeal and hypopharyngeal mucosa. 24 , 25 Such inflammation can additionally aggravate pre-existing radiomucositis in irradiated patients, leading to scarring and impaired sensitivity of involved mucosa. Reflux to the level above the upper esophageal sphincter was found to impair the