Emma Aitken, Alex Vesey, Julie Glen, Mark Steven and Marc Clancy
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4. Mishra J, Dent C, Tarabishi
Guy Sydney, Kalliopi Ioakim, Nayia Kara and George Pantelas
carcinoma in the head and neck: An evaluation of 22 cases in 671 patients. Int Braz J Urol, 2017;43:202-208.
9. Hussain F, Yedavalli N, Loeffler D, Kajdacsy-Balla A. Solitary parotid metastasis 8 years after a nephrectomy for renal cell carcinoma. J Community Hosp Intern Med Perspect, 2016; 6:31950.
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11. Balaban M, Vudali Dogruyol S, Idilman
Dariusz Waniczek, T. Kamiński, H. Augustyniak, D. Nadbrzeżna and A. Czarniecka
Thyroid gland is a rare site for distant metastases. The aim of this study is to present a rare case of an isolated metastatic clear cell renal cell cancer (ccRCC) in the thyroid gland seven years after left-sided nephrectomy.
A neck cancer discovered by clinical examination, diagnosed by ultrasound-guided USG fine-needle biopsy was removed by surgery. Palliative thyroidectomy with consecutive neck radiotherapy was finished without any complications, except a temporary, asymptomatic hypocalcaemia. After six month remission, the patient’s general condition deteriorated, multiorgan RCC dissection appeared leading to the patient’s death
Background. The purpose of this paper is to present the epidemiology, diagnostic workup and treatment of renal cell carcinoma (RCC) with an emphasis on the Slovenian epidemiological data. RCC represents 2% of all cancers and is the third most common genitourinary tract tumour. It most frequently occurs among people of ages, between 50 and 60 years. Male patients are more prone to it than female. A number of environmental, occupational and genetic factors have been found to be associated with the development of RCC. Patients often have nonspecific symptoms and this is the reason why for half of them the disease is already metastatic when diagnosed. The most common sites of metastases are lungs (75%), followed by soft tissues (36%), bones (20%), liver (18%), skin (8%) and central nerve system (8%). In the evaluation of RCC multiple diagnostic procedures are needed with obligatory image diagnostics.
Conclusions. Radical nephrectomy is still the mainstream treatment of localized disease. Nephron sparing techniques have been used in cases, where radical operation would result in an anephric patient. Efficient adjuvant therapy has not been discovered yet. Until recently interpherone and interleukin were the only known effective treatments for metastatic disease, but now new and more efficient biologic agents are being discovered. The most important prognostic factor for survival is stage at the beginning of treatment. The 5-year survival rate is 95% for patients with stage I disease, 88% for stage II, 59% for stage III and 20% for stage IV.
Anastasios Kyriazoglou, Ioannis Dimitriadis and Aristotelis Bamias
patients with localised clear-cell RCC at high risk for tumour recurrence after nephrectomy (pT > 3 and/ or pN+) (21) . Adverse events were significantly higher with sunitinib treatment. The recent results from PROTECT trial, unfortunately, did not offer conclusive evidence in favour or against adjuvant treatment. Adjuvant administration of pazopanib did not meet its primary endpoint of prolonging DFS [hazard ratio: 0.862; 95% confidence interval, 0.699, 1.063; p = 0.165] in the decreased dosage of 600 mg daily, which was needed in order to control toxicity
with renal cell carcinoma with multiple lung metastases. He underwent left nephrectomy in November 2016 and he was addressed to the oncology department for further treatment. He started treatment with sunitinib50 mg per day, 4 weeks/6, with initial creatinine clearance of 40 ml/min.
Results : After 2 months of treatment creatinine level moved to 2.84 mg/dl and 2 months later to 3.43mg/dl. The patient developed proteinuria over 3 gr/24h. Sunitinib was discontinued and imaging reevaluation was performed, which revealed a complete response. Two months later
Călin Molnar, Octavian-Sabin Tătaru, Lucian Mărginean and Angela Borda
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3. Shuch B1, Bratslavsky G, Linehan WM, Srinivasan R. Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. Oncologist . 2012
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Diana-Silvia Zilişteanu, Teodora Atasie and M. Voiculescu
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20. LI P, MA LL, XIE RJ, et al. Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure . Acta Pharmacologica Sinica 2012; 33 : 644–651.
Carmelo Caldarella, Barbara Muoio, Maria Antonietta Isgrò, Emilio Porfiri, Giorgio Treglia and Luca Giovanella
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