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Diagnosis and management of complications of chronic lymphocytic leukemia/small lymphocytic lymphoma

complications for CLL appear to be increased by regimens including idelalisib. Combination therapy clinical trials including idelalisib were halted by the Federal Drug Administration and European Drug Agency because of concerns for excess toxicity including increased rates of PJP and CMV infections [ 29 ]. There are limited data on the effect of duvelisib and umbralisib on risk of infection in CLL patients. Management Management of infection in CLL patients requires education of patients and care givers to respond rapidly to evidence of infection, appropriate

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The influence of hemodialysis on FibroTest parameters

Abstract

Chronic hepatitis C viral infection is an important cause of morbidity and mortality in patients with end-stage renal disease treated with hemodialysis. Liver fibrosis represents a main determinant of liver disease prognosis and clinical management, and its assessment by liver biopsy can decide treatment allocation. Although liver biopsy is the gold standard for staging liver fibrosis, it is an invasive procedure associated with complications that are more prevalent in patients with end-stage renal disease. FibroTest represents a surrogate marker of fibrosis which evaluates the levels of apolipoprotein A1, total bilirubin, haptoglobin, gamma-glutamyltransferase and α2-macroglobulin, generating a score that indicates the level of fibrosis. Discrepancies were observed in clinical practice between FibroTest score and histopathological findings. The aim of this study was to evaluate how hemodialysis influences the level of each FibroTest parameter and the final score. The systematic literature review conducted by us suggests that hemodialysis induces a reduction in apolipoprotein A1, haptoglobin and bilirubin levels, with an increase in gamma-glutamyltransferase and alpha-2-macroglobulin levels. In conclusion, hemodialysis modifies the levels of FibroTest parameters, suggesting that it may also have an impact on the accuracy of liver fibrosis assessment in hemodialysis patients.

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Discriminating between nesting and non-nesting habitat in a vulnerable bird species: implications for behavioural ecology

implications for management. European Journal of Wildlife Research, 55, 597–602. Barrientos, R., Valera, F., Barbosa, A., Carrillo, C.M. & Moreno, E. (2009) Plasticity of nest-site selection in the trumpeter finch: A comparison between two different habitats. Acta Oecologica, 35 (4), 499–506. Block, W.M. & Brennan, L.A. (1993) The habitat concept in ornithology: Theory and applications. Current Ornithology, 11: 35–91. Bibby, C.J., Burgess, N.D., Hill, D.A. & Mustoe, S.H. (2000) Bird census techniques, 2nd edn. Academic Press, New York. Browne, S

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Hemolysis has no influence on routine coagulation tests in subjects without anticoagulant therapy - a referral Romanian emergency hospital laboratory experience

department of a scottish hospital. Scott Med J. 2014;59(2):91-4. DOI: 10.1177/0036933014529056 4. Lippi G, Salvagno G, Montagnana M, Lima-Oliveira G, Guidi G, Favaloro EJ. Quality standards for sample collection in coagulation testing. Semin Thromb Hemost. 2012;38(6):565-75. DOI: 10.1055/s-0032-1315961 5. Lippi G, Plebani M, Favaloro EJ. Interference in coagulation testing: Focus on spurious hemolysis, icterus, and lipemia. Semin Thromb Hemost. 2013;39(3):258-66. DOI: 10.1055/s-0032-1328972 6. Lippi G, Cervellin G, Favaloro E, Plebani M. Management of

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The angiotensinogen gene polymorphism, lifestyle factors, associated diseases and gastric areas of inflammatory and preneoplastic lesions in a Romanian sample of patients

. Dinis-Ribeiro M, Areia M, de Vries AC, Marcos-Pinto R, Monteiro-Soares M, O’Connor A, et al. Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Endoscopy. 2012 Jan; 44(1):74-94. DOI: 10.1055/s-0031-1291491 5. Karimi P, Islami F, Anandasabapath S, Freedman ND, Kamangar F. Gastric cancer: descriptive epidemiology, risk factors

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Long-term species richness-abundance dynamics in relation to species departures and arrivals in wintering urban bird assemblages

.H. & Nilon, C.H. (2010) Invasion, competition, and biodiversity loss in urban ecosystems. Bioscience, 60, 199–208. Shochat, E., Warren, P., Faeth, S., McIntyre, N. & Hope, D. (2006) From patterns to emerging processes in mechanistic urban ecology. Trends in Ecology and Evolution, 21, 186–191. Smith, P. G. (2003) Winter bird use of urban and rural habitats in Ontario. Canadian Field-Naturalist, 117, 173–183. Smith, P. G. (2007) Characteristics of urban natural areas influencing winter bird use in southern Ontario, Canada. Environmental Management, 39, 338

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Postępowanie u pacjentek z nowotworem mieloproliferacyjnym BCR-ABL ujemnym w ciąży

ekspertów Hct powinien być dostosowany do normy obowiązującej w danym trymestrze ciąży (31-41% w I trymestrze, 30-38% w II trymestrze i 28-39% w III trymestrze) [ 16 ]. Nie jest wskazana suplementacja żelaza ze względu na ryzyko wzrostu parametrów czerwonokrwinkowych. Tabela II Terapia u pacjentki z nowotworem mieloproliferacyjnym w ciąży w zależności od czynników ryzyka [ 5 , 14 , 16 ] Table II. Management of pregnant women with myeloproliferative neoplasm according to risk factors [ 5 , 14 , 16 ] Ryzyko Terapia w trakcie ciąży Terapia w trakcie

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ABC of viral infections in hematology: focus on herpesviruses

are ambiguous. The summary, based on large studies, is presented in table XI Conclusions Because of high worldwide seroprevalence and latency, infections with herpesviruses are, and will be, frequent. Current strategies of management of CMV and EBV are based on mandatory monitoring of DNA-emia and administration of preemptive therapy if DNA-emia is positive; however, pharmacological prophylaxis is a renewed possibility in case of CMV (letermovir) and is an option for EBV infection (rituximab). In case of HHV-6, no routine screening is recommended; however, in

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Infectious complications in children and adults with hematological malignancies

transplantation patients: a surmountable challenge Hematology Am Soc Hematol Educ Program 2012 2012 265 70 [7] Ljungman P, de la Camara R, Cordonnier C, et al. European Conference on Infections in L: Management of CMV, HHV-6, HHV-7 and Kaposisarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant 2008;42:227-40. 10.1038/bmt.2008.162 Ljungman P de la Camara R Cordonnier C et al European Conference on Infections in L: Management of CMV, HHV-6, HHV-7 and Kaposisarcoma herpesvirus (HHV-8

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