Introduction. The introduction of sodium glucose cotransporter 2 inhibitors in the management of diabetes was an innovation in the treatment of this disease, considering the protective cardiovascular effect not only the ability of decreasing the plasma glucose. In Europe, this class of medication is approved for the treatment of type 2 diabetes and some of them (dapagliflozin and sotagliflozin) are also approved for use in certain patients with type 1 diabetes mellitus. These patients must have inadequate control of their blood glucose levels despite optimal insulin therapy. One of the adverse effects is diabetic ketoacidosis.
Case report. This case report presents a diabetic patient whose treatment was changed from insulin therapy to oral therapy. Within 10 days after the initiation of the new treatment her condition gradually worsened and she arrived at the emergency room with nausea, vomiting and altered general condition. She was admitted for euglycemic ketoacidosis and treated according to the protocol.
Conclusions. This case reveals the importance of continuing the insulin therapy when adding a sodium glucose cotransporter 2 inhibitor in type 1 diabetes patients.
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into eight types: knowledge spillover effect, innovation effect, scale effect, time effect, information sharing effect, collective learning effect, incentive effect and regional effect.
From the various expositions on the meaning of talent agglomeration, it can be seen that while the concept is stated differently by different researchers, all nevertheless highlight the essence of talent agglomeration, namely, talent agglomeration is a special phenomenon in the flow of talents and the action or phenomenon of clustering of individual talents in geographical space
prospective, randomized, and multicenter studies are the main research directions in the future. Innovation is needed in the scientific research in TCM. The TCM research that meets the clinical needs, aims to improve the level of prevention and treatment of major diseases in China, will get further developed.
Source of Foundation
The present study was supported by the Special Research Funds for Traditional Chinese Medicine Industry from State Administration of Traditional Chinese Medicine (201407001) and National Natural Science Foundation Project (grant No. 81774092
Xianglin Zhang, Fangfang Fan, Yong Huo and Xiping Xu
of hypertension in China and in other populations with similar characteristics.
Sources of Financial Support
Including from the Projects of National Natural Science Foundation of China (grants No. 81473052, 81441091, and 81402735); the Major State Basic Research Development Program of China (973 program) (2012 CB517703); Clinical Center (grant No. zx09401013); National Science and Technology Major Projects Specialized for “Major New Drugs Innovation and Development” during the 12th Five-Year Plan Period: China Stroke Primary Prevention Trial (grant No. zx