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Salivary Theranostics in Pediatric and Special Care Dentistry

References 1. Tabak LA. Point-of-Care Diagnostics Enter the Mouth. Ann NY Acad Sci, 2007;1098:7-14. 2. Richard L, Furler J, Densley K, Haggerty J, Russell G, Levesque JF, Gunn J. Equity of access to primary healthcare for vulnerable populations: the IMPACT international online survey of innovations. Int J Equity Health, 2016;15:64. 3. Bersell CH. Access to Oral Health Care: A National Crisis and Call for Reform. J Dent Hyg, 2017;91:6-14. 4. Petrovic B, Markovic D, Peric T. Evaluating the population with intellectual disability unable to

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Innovation and Discovery

REFERENCES 1. Khan BZ. Looking Backward: Founding Choices in Innovation and Intellectual Property Protection. Available at: . 2. Mumford L. Technics and Civilization. Available at: 3. Patents And Innovation: Trends And Policy Challenges. Available at: 4. Giugni D, Giugni V. Intellectual Property: a powerful tool to develop biotech research. Microb Biotechnol . 2010;3:493-506.

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Euglycemic Ketoacidosis Diagnosis and Treatment Protocol in Type 1 Diabetes Patient


Introduction. The introduction of sodium glucose cotransporter 2 inhibitors in the management of diabetes was an innovation in the treatment of this disease, considering the protective cardiovascular effect not only the ability of decreasing the plasma glucose. In Europe, this class of medication is approved for the treatment of type 2 diabetes and some of them (dapagliflozin and sotagliflozin) are also approved for use in certain patients with type 1 diabetes mellitus. These patients must have inadequate control of their blood glucose levels despite optimal insulin therapy. One of the adverse effects is diabetic ketoacidosis.

Case report. This case report presents a diabetic patient whose treatment was changed from insulin therapy to oral therapy. Within 10 days after the initiation of the new treatment her condition gradually worsened and she arrived at the emergency room with nausea, vomiting and altered general condition. She was admitted for euglycemic ketoacidosis and treated according to the protocol.

Conclusions. This case reveals the importance of continuing the insulin therapy when adding a sodium glucose cotransporter 2 inhibitor in type 1 diabetes patients.

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Editorial and Publishing Policies

References Spiroski M, Gogusev J. Macedonian Medical Journals Have Very Limited Scientific Influence. Maced J Med Sci. 2008;1(2):10-16. Chaifetz S, Chokshi DA, Rajkumar R, Scales D, Benkler Y. Closing the access gap for health innovations: an open licensing proposal for universities. Global Health. 2007;3:1. doi:10.1186/1744-8603-3-1 PMID:17270051 Macklin R. The Declaration of Helsinki: another revision. Indian J Med Ethics

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Almanac 2013: novel non-coronary cardiac interventions


Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation is often associated with comorbidities which make surgery high risk. The MitraClip is a promising percutaneous alternative to surgical valve repair or replacement. Other procedures discussed in this review are the percutaneous left atrial appendage closure as a non-pharmacologic therapy to prevent strokes, and renal denervation for resistant hypertension. This review explains the basic principles of these procedures, the most important clinical evidence, and also provides additional recent clinical data on each of these them.

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The Analysis of Prevalence and Incidence of Diabetes Mellitus in Romania

References 1. World Health Organization . Noncommunicable Diseases Country Profiles 2011. WHO Global Report. Geneva, Switzerland: WHO, 2011. Accessed on January 05, 2013 at: 2. Kaplan W, Laing R . Priority medicines for Europe and the world - a public health approach to innovation. Geneva: World Health Organization ; 2004. Accessed on January 05, 2013 at: 3. International Diabetes

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Updates in Parenteral Nutrition

References 1. Agency for Clinical Innovation. Parenteral nutrition pocketbook: for adults. Chatswood, Australia: Agency for Clinical Innovation, 2011. 2. Kumpf VJ, Mirtallo JM, Peterson C. Parenteral Nutrition Formulation: Preparation and Ordering. In: The A.S.P.E.N. Nutrition Support Practice Manual, 2nd ed; Merritt R (eds); Silver Spring, pp 97-108, 2005. 3. American Society for Parenteral and Enteral Nutrition. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN - J Parenter Enteral Nutr 26 (1 Suppl

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Moderate-Vigorous Physical Activity and Clinical Parameters in Adults with Type 2 Diabetes Mellitus: A Report from the Walking with Diabetes Study

around the world. McKinsey’s Center for Healthcare Research and Innovation (CHRI) 2016. 5. Colberg SR, Sigal RJ, Yardley JE et al . Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care 39(11): 2065-2079, 2016. 6. Rader DJ . Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med 120(3): S12-S18, 2007. 7. Long AN, Dagogo-Jack S . Comorbidities of diabetes and hypertension: mechanisms and

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