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Introduction. The introduction of sodium glucose cotransporter 2 inhibitors in the management of diabetes was an innovation in the treatment of this disease, considering the protective cardiovascular effect not only the ability of decreasing the plasma glucose. In Europe, this class of medication is approved for the treatment of type 2 diabetes and some of them (dapagliflozin and sotagliflozin) are also approved for use in certain patients with type 1 diabetes mellitus. These patients must have inadequate control of their blood glucose levels despite optimal insulin therapy. One of the adverse effects is diabetic ketoacidosis.
Case report. This case report presents a diabetic patient whose treatment was changed from insulin therapy to oral therapy. Within 10 days after the initiation of the new treatment her condition gradually worsened and she arrived at the emergency room with nausea, vomiting and altered general condition. She was admitted for euglycemic ketoacidosis and treated according to the protocol.
Conclusions. This case reveals the importance of continuing the insulin therapy when adding a sodium glucose cotransporter 2 inhibitor in type 1 diabetes patients.
Daphne Kaitelidou, Maria Kalogeropoulou, Theofanis Katostaras, Olympia Konstantakopoulou, Panagiotis Minogiannis, Alexandra Skitsou, Olga Siskou, Georgios Charalampous, Alexandros Ardavanis and Lykourgos Liaropoulos
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numerous treatment planning studies comparing different modalities ( i.e . 3D-CRT vs . IMRT vs . VMAT) and usually depends on the available equipment, technical innovations, irradiated volume, treatment planning system with dose calculation algorithm, and skills of the planner.
There are numerous publications comparing the dosimetric parameters of radiotherapy plans, mostly for patients with left-sided early BC. Some of them have been summarised in a review of treatment planning options by Balaji et al . where most authors favoured hybrid planning techniques (3D CRT