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Imatinib-induced subclinical liver injury: histological changes of non-tumorous hepatic parenchyma

References 1. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002; 347:472-80. 2. Schwetz BA. New Treatment for Chronic Myelogenous Leukemia. JAMA. 2001; 286:35. 3. Cohen MH, Williams G, Johnson JR, Duan J, Gobburu J, Rahman A, et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res. 2002; 8: 935

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Systemic Treatment for Soft Tissue Sarcoma: What is Standard, What is New


Soft tissue sarcoma (STS) is a biologically heterogeneous malignancy with over 50 subtypes. This solid tumor is one of the most challenging diseases to treat for the medical oncologist. STS often forms in the body’s muscles, joints, fat, nerves, deep skin tissues, and blood vessels. The natural history of high-grade STS is characterized by a strong tendency toward local recurrence and metastatic spreading, despite optimal initial strategies. The lung is the most common site of metastases, with poor prognosis. We present the current international guidelines for the adjuvant treatment and systemic treatment for advanced STS and the new discoveries. Many new molecular targeting drugs have been tried in the last ten years, and some were approved for soft tissue sarcoma. The first approved was Imatinib, as a treatment for gastrointestinal stromal tumors (GISTs). Following Imatinib, other tyrosine kinase inhibitors (TKIs) received the approval for GISTs such as Sunitinib and Regorafenib, and Pazopanib for non-GIST soft tissue sarcomas. In 2016, FDA approved the first monoclonal antibody that targets platelet-derived growth factor receptor (PDGFR)-α, Olaratumab. The new treatment demonstrates an overall survival advantage. In this review, we aimed to summarize the results from the most recent studies on adjuvant treatment for high-grade STS and systemic strategies for advanced STS.

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Efficacy of differential non-invasive approaches in determining the clinical course in patients with Crohn’s disease

:335-42. 39. Chen Y, Tzengb C, Lioub C, Changb M, Lib C, Linb C. Biological significance of chromosomal imbalance aberrations in gastrointestinal stromal tumors. J Biomed Sci. 2004; 11:65-71. 40. Rossner P, Boffetta P, Capp M, Bonassi S, Smerhovsky Z, Landa K, et al. Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer. Environ Hlth Persp 2005; 113:517-20. 41. El-Zein R, Gu Y, Sierra MS, Spitz MR, Strom SS. Chromosomal instability in peripheral blood lymphocytes and risk of prostate cancer. Cancer Epidemiol Biomarkers

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Wall vacuum-assisted closure technique for a complex enteroatmospheric fistula: report of a case

-assisted closure (VAC) have been proposed; however, there is no single universal technique that can be applied to every EAF because each fistula is different [ 3 ]. Hence, the wound care of EAF should be individualized for each patient. We report a novel VAC technique used to contain the fistula effluent and protect skin in a patient with a complex EAF. Case report A 53-year-old male patient presented with abdominal pain and mass. A diagnosis of a malignant gastrointestinal stromal tumor of the stomach with peritoneal seeding was made, and the patient underwent exploratory

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Epidemiology of upper gastrointestinal bleeding and Helicobacter pylori infection: review of 3,488 Thai patients

. These cancers are presented in ( Table 2 ) . Table 2 Type of malignancy that caused upper gastrointestinal bleeding with proved tissue-pathology Type of cancer Number of patients Gastric cancer (adenocarcinoma) 36 Gastric lymphoma 15 Other cancers metastasis 15 Esophageal cancer (squamous cell carcinoma) 12 Gastrointestinal stromal tumor (GIST) 11 Ampullary cancer (adenocarcinoma) 4 Periampullary cancer 3 Pancreatic cancer 3 Duodenal cancer (adenocarcinoma) 1

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