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Prognostic Biomarkers in Early-Stage B-CLL Patients

. Zucchetto A, Vaisitti T, Benedetti D, Tissino E, Bertagnolo V, Rossi D, et al. The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia. 2012;26(6):1301-12. 13. Bulian P, Shanafelt TD, Fegan C, Zucchetto A, Cro L, Nückel H, et al. CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. J. Clin. Oncol. 2014;32(9):897-904. 14. Gentile M, Cutrona G, Neri A, Molica S, Ferrarini M, Morabito F. Predictive value of β2-microglobulin (β2-m) levels

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Alterations in Platelet Activity and Elastic Modulus of Healthy Subjects, Carriers of G20210A Polymorphism in the Prothrombin Gene

Summary

Platelet activation is a complex process in which platelet reorganization takes place associated with changes in the cell shape, topology, membrane elasticity and microparticle production. The aim of this study was to investigate the changes/aberrations in the platelet activity, elasticity and morphology in healthy subjects, carriers of A allele of prothrombin G20210A polymorphism. Blood samples from 18 healthy subjects were used for platelet analysis by force-mode atomic force microscopy. Restriction analysis was used to investigate the carriage of G20210A polymorphism in the prothrombin gene. Flow- cytometry was applied to evaluate platelet activation. Young’s modulus of the plasma membranes of platelets derived from healthy subjects, carriers of variant A allele of prothrombin 20210G>A polymorphism (407±69 kPa) is two times higher than the one determined for non­carriers (195.4±48.7 kPa; p<0.05). The background activity of platelets measured as an interrelation of Cd41/Cd61 and CD62 by flow cytometry was also higher in carriers of variant A allele of prothrombin 20210G>A polymorphism (5.0%) than in non-carriers (1.3%). Platelets isolated from healthy carriers of variant A allele of prothrombin 20210G>A polymorphism exhibited a higher level of activity and a higher degree of stiffness at the stage of spreading as compared to platelets from non­carriers.

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Intrafetal Laser Coagulation for Trap Sequence in a Complicated Dichorionic Triamniotic Triplet Pregnancy Case Report and Review of the Literature

Summary

A rare case is reported of twin-reversed arterial perfusion (TRAP) sequence in a triplet pregnancy, fetal intervention in the first trimester and pregnancy outcome. We report a case of TRAP sequence complication in dichorionic triamniotic triplet pregnancy, with a normally developing fetus and an acardiac fetus connected via arterio-arterial anastomoses in a monochorionic diamniotic twin pair and a separate fetus. TRAP sequence was diagnosed at 13 weeks in triplet pregnancy after in vitro fertilization (IVF) and embryo transfer of two blastocysts. Color Doppler assessment showed persistent arterial flow in the acardiac twin. Intrafetal laser coagulation was carried out at the time of the diagnosis, and the pregnancy outcome was two survivals at 36.4 weeks of gestation.

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Original Article. Urinary Tract Desobstruction in Patients with Malignant Neoplasms of the Uterine Cervix

Summary

Cancer of the cervix causes internal, external compression or both of the upper urinary tract in 50-60%of patients in advanced stages. Retrograde stenting is the most widely used technique for desobstruction of the upper urinary tract in urology practice. Diversion of urine flow is an alternative, achieved by nephrostomy of one or both kidneys.We studied retrospectively 33 women with upper urinary tract obstruction caused by carcinoma of the uterine cervix operated on between March 2014 and March 2015 in the urology clinic at the University Hospital in Pleven, Bulgaria. Apercutaneous nephrostomy (PNS) was placed in 17 patients, and 11 patients hadaretrograde catheterization with ureteral stent type JJ. Five patients were treated with both methods. Placement ofa JJstent was the first choice procedure for all patients since it providesabetter quality of life. PNSimproves renal function faster than retrograde JJstenting. Therefore, the first method of choice for patients with an untreated primary cervical, uterine cancer is the placement of PNS. Retrograde JJstenting is the method of choice in patients who undergo surgery and radiation therapy withoutarelapse of the disease.

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Effects of Long-Term Treatment with Atorvastatin and Rosuaastatin on Active Avoidance Test in Intact Rats

. 2006;40( 10): 1880-3. 8. Kalonia H, Kumar P, Kumar A. Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats. Behav Brain Res. 2011;216(1): 220-8. 9. Wang H, Lynch JR, Song P, Yang HJ, Yates RB, Mace B, et al. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol. 2007;206(1): 56-69. 10. Ucak A, Onan B, Guler A, Sahin MA, KihqkayaO, Oztaș E, et al. Rosuvastatin

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Toxicological Chemical Analysis of Methanol in Blood of Patients with Acute Ethanol Intoxication for Determining Detectable Quantities of Methanol and Analysis of the Correlation Between Ingested Alcohol

/Environment/MP-Methanol-Fate.aspx. 6. Heward A. PN 06/14 (NAM7): Upgraded MERLIN spies cloud of alcohol spanning 28https://www.ras.org.uk/search/article-archi-ve/973-pn-0614-nam7-upgraded-merlin-spies-cloud-of-alcohol-spanning-288-billion-miles. 7. Monte WC. Aspartame; methanol and the public health. JApplNutr. 1984;36(l):42-58. 8. Turner C, Spanel P, Smith D. A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS. Physiol Meas. 2006;27(7):637-48. 9. Sedived V, Mraz M

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Original Article. Matrix Metalloproteinase Mmp-2 and Mmp-9 Activities in Seminal Plasma

;114(11):2125-34. 9. Qing-Xiang Sang, Dym M, Bryer SW. Secreted Metalloproteinases in Testicular Cell Culture. Biol Reprod. 1990;43:946-55. 10.World Health Organization. WHOlaboratory manual for the Examination and processing of human semen. 5 ed. Geneva: World Health th Organization; 2010. 11. Lukanov T, Lichev D, Konova E, Emin A, Ayvazova N, Roussev G R, et al. Investigation of Sperm Dna Fragmentation By Sperm Dna Integrity Assay. Jof IMAB. 2008;1:11-4. 12. Lukanov T, Lichev D, Konova E, Emin A, Ayvazova N, Roussev G R, et al. Flow

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Risk Factors for Coronary Artery Diseases: A Study Among Patients With Ischemic Heart Disease in India (Kerala)

Cardiol. 2001 ;38(3):682-7. 22. Scheuner MT. Genetic evaluation for coronary artery disease. Genet Med. 2003;5(4):269-85. 23. SchachingerV, Britten MB, Eisner M, Walter DH, Scharrer 1, Zeiher AM. Apositi ve family history of premature coronary artery disease is associated with impaired endothelium-dependent coronary blood flow regulation. Circulation 1999; 100( 14): 1502-8. 24. Enas EA, Yusuf S, Sharma S. Coronary artery disease in South Asians: Second Meeting of the International Working Group 16 March 1997, Anaheim

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Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker

. Wang H, Li W, Zhu S, Li J, D’Amore J, Ward MF, Yang H, et al. Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats. J Cereb Blood Flow Metab. 2010;30(3):493-504. 51. Daveau M, Davrinche C, Djelassi N, Lemetayer J, Julen N, Hiron M, et al. Partial hepatectomy and mediators of inflammation decrease the expression of liver 2-HS glycoprotein gene in rats. FEBS Lett. 1990;273(1-2):79-81. 52. Ismail NA, Ragab S, Abd El Dayem SM, Elbaky AA, Salah N, Hamed M, et al. Fetuin-A levels in obesity: differences in relation to

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Association of Coronary Wall Shear Stress With Atheromatous Plaque Vulnerability: A Systematic Review

. Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future: A Serial Optical Coherence Tomography and Computational Fluid Dynamics Study. Circ Cardiovasc Interv 2017;10:e005455 10. Timmins LH, Molony DS, Eshtehardi P, Mc- Daniel MC, OshinskiJN, Giddens DP,et al. Oscillatory wall shear stress is a dominant flow chaacteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary arterydisease. J R Soc Interface 2017;14:20160972 11. Liu X, Wu G, Xu C, He Y, Shu

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