development of the functional MRI in the 1990s is credited to Seiji Ogawa and Ken K. Kwong [ 13 , 14 ].
fMRI works by detecting the changes in blood oxygenation and flow that occur in response to neural activity – when a brain area is more active it consumes more oxygen and to meet this increased demand blood flow increases to the active area. Oxygen is delivered to neurons by hemoglobin in capillary red blood cells. When neuronal activity increases there is an increased demand for oxygen and the local response is an increase in blood flow to regions of increased neural
- based case-control study in Japan. J Stroke Cerebrovasc Dis. 2014;23(2):343-8.
38. Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, et al. The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nat Commun. 2011;2:485.
39. Sundt TJ, Sharbrough FW, Piepgras DG, Kearns TP, Messick JJ, O'Fallon WM. Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc. 1981
F. Salle, A. Jaume, G. Castelluccio and E. Spagnuolo
occlusion, 2,9% with near-total occlusion (91-99% of the volume of the aneurysm), 5,9% for partially occluded aneurysms (70-90%) and 17,6% for aneurysms with less than 70% of their volume occluded.
Tamatani et al. [ 8 ] demonstrated a strong correlation between stability of aneurysms and their embolized volume. Partially occluded aneurysms tend to be unstable lesions. It is agreed that approximately one third of coiled aneurysms will become recanalized, particulary under high shear stress and high flow velocity conditions. Persistent aneurysm filling after coil