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Measurement of platelet p-selectin expression by flow cytometry in patients with acute ischemic stroke

, lacunar infarcts and multiple infarct dementias. Thromb Res 1993;72: 295–304. 14. Michelson AD. Flow cytometry: a clinical test of platelet function. Blood 1996;87:4925 – 36. 15. Minamino T, Kitakaze M, Sanada S, Asanuma H, Kurotobi T, et al. Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide. Circulation 1998;98:1721–27. 16. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal

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Early Postnatal Changes in the Superior Mesenteric Artery Blood Flow Parameters in Late Preterm Newborns - A Pilot Study

microcirculation: still a mystery? British Journal of Anaesthesia 2010; 105 (4): 393 - 6. 5. Keese M, Schmitz-Rixen T, Schmandra T. Chronic mesenteric ischemia: Time to remember open Revascularization. World J Gastroenterol 2013; 19 (9): 1333 - 1337. 6. Papacci P, Giannantonio C, Cota F et al. Neonatal colour Doppler ultrasound study: normal values of abdominal blood flow velocities in the neonate during the first month of life. Pediatr Radiol 2009; 39: 328 - 335. 7. Matasova K, Zibolen M, Kolarovszka H et al. Early postnatal

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Role of VASP Phosphorylation Assay in Monitoring the Antiplatelet Therapy

-7. 9. Gachet C, B.Aleil B, Testing antiplatelet therapy. European Heart Journal Supplements 2008; 10 (Suppl A), A28-A34. 10. Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 3: 85-92. 11. STAGO - Biocytex ® (France), Manual for PLT VASP/P2Y12 kit; user_upload/Biocytex/7014-english

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Left main stenting induced flow disturbances on ascending aorta and aortic arch

Introduction Effects of coronary stenting techniques are generally investigated regarding wall shear stress (WSS) or turbulence of flow at the lesion or bifurcation sites. [ 1 , 2 ] Recently, we speculated that ostial left main (LM) stenting potentially induces turbulence in the aortic wall near to the LM ostium. [ 3 ] Potential impact on the ascending aorta and arch have never been evaluated despite the fact that it would be logical that any turbulence induced outside the coronary tree can propagate at a certain distance within the aortic vasculature

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Assessment of the Peripheral Blood Flow of Lower Limbs in Patients with Diabetes Mellitus with the Use of Digital Photoplethysmography


Introduction: The microcirculation of the lower limbs (LL) of diabetics is influenced by hyperglycemia and several factors (hypertension, obesity, dyslipidemia) leading to the functional and later the structural changes, manifesting as dysregulation of the peripheral blood flow.

Materials and Methods: The study included 39 patients with type 2 diabetes, and the same number of the control group. The digital photoplethysmography (PPG) was used for assessment of the peripheral circulation with reflectance mode, sensing from the 1st and 2nd toe of the LL after acclimatisation of the patient in the supine position. The subjects were also asked to refrain from smoking, to avoid drinks containing caffeine and using of medicaments with vasodilatator function at least 2 hours before examination.

Results: The pulse amplitudes and the peak times of the PPG curves were significantly higher in diabetic group than in the control group. The mean pulse amplitudes in diabetics were in the range of 0.69 % 0.86 %, the pulse peak time in the range of 140 - 154 ms. The mean pulse amplitudes in the control group were in the range of 0.37 0.54 %, the mean pulse peak time were in the range of 120 - 133 ms. The PPG findings of the LL were symmetrical (non-significant t-test). We have not found a correlation between the PPG records and duration, compensation of diabetes, age, glycemia, blood pressure, dyslipidemia, smoking and obesity.

Conclusion: This simple-to-use technique shows the increased total skin microcirculation in diabetic patients. Microvascular shunting of blood presenting in peripheral nerves and in the skin of diabetic feet are responsible for reduced hyperemia response to any inflammatory process with the increased susceptibility for inquiring the diabetic foot infection.

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A Comparative Preliminary Study on CT Contrast Attenuation Gradient Versus Invasive FFR in Patients with Unstable Angina

, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol. 2010;55:2816-2821. doi: 10.1016/j.jacc.2009.11.096. 4. De Bruyne B, Pijls NH, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991-1001. doi: 10.1056/NEJMoa1205361. 5. Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007

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Splanchnic Circulation in Small for Date Newborns

, Jansson T, Rangel - Nava H, Gratacos E. Changes in regional fetal cerebral blood flow perfusion in relation to hemodynamic deterioration in severely growth restricted fetuses. Ultrasound Obstet Gynecol 2008; 32: 71 - 76. 5. Mari G, Abuhamad AZ, Uerpairojkit B, Martinez E, Copel JA. Blood flow velocity waveforms of the abdominal arteries in appropriate - and small - for - gestational - age fetuses. Ultrasound Obstet Gynecol 1995; 6: 15 - 18. 6. Korszun P, Dubiel M, Breborowicz G, Danska A, Gudmudsson S. Fetal superior mesenteric blood flow

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Comparative computed flow dynamic analysis of different optimization techniques in left main either provisional or culotte stenting

been investigated in the standard coronary artery bifurcation. Which is the ideal technique in the LM bifurcation scenario independent of the provisional or dual stenting techniques? As designing a randomized trial evaluating the outcomes of such different techniques in a homogeneous population of LM disease is conceptually impossible and economically expensive, computational fluid dynamic (CFD) analysis,[ 9 ] which has been applied in many fields of cardiovascular medicine, may give at least a suggestion on the impact of such techniques on flow physiology and may

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Phototherapy and its effect on some physiological functions in newborns

(9):1410-8. 29. Benders MJ, Van Bel F, Van de Bor M. Haemodynamic consequences of phototherapy in term infants. Eur J Pediatr 1999; 158:323–8. 30. Benders MJ. The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr 1998; 87:786–92. 31. Benders MJ, Van Bel F, Van de Bor M. The effect of phototherapy on renal blood flow velocity in preterm infants. Biol Neonate 1998; 73:228–234. 32. Borenstein-Levin L, Sharif D, Amshalom A, Riskin A, Khalil A, Bader D, Kugelman A. Effects of Phototherapy on Coronary Blood Flow in Healthy

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On-treatment platelet reactivity in the era of new ADP receptor blockers: data from a real-world clinical practice

REFERENCES [1] Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Alfonso F, Macaya C, Bass TA, Costa MA. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 2007; 49: 1505 - 1516 [2] Fedor M, Samoš M, Šimonová R., et al. Monitoring the Efficacy of ADP Inhibitor Treatment in Patients With Acute STEMI Post-PCI by VASP-P Flow Cytometry Assay. Clin Appl Thromb Hemost. 2015; 21: 334 – 338. [3] Lhermusier T, Lipinski MJ, Tantry US, Escarcega RO, Baker N, Bliden KP et al

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