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Lenka Kočvarova, L. Lucanova, J. Zibolenova, E. Paulusova and K. Matasova
microcirculation: still a mystery? British Journal of Anaesthesia 2010; 105 (4): 393 - 6.
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Gianluca Rigatelli, Marco Zuin, Alan Fong, Truyen TTT Tai and Thach Nguyen
Effects of coronary stenting techniques are generally investigated regarding wall shear stress (WSS) or turbulence of flow at the lesion or bifurcation sites. [ 1 , 2 ] Recently, we speculated that ostial left main (LM) stenting potentially induces turbulence in the aortic wall near to the LM ostium. [ 3 ] Potential impact on the ascending aorta and arch have never been evaluated despite the fact that it would be logical that any turbulence induced outside the coronary tree can propagate at a certain distance within the aortic vasculature
G. Hubena, O. Osina, Busikova Prindesova and T. Vasicko
Introduction: The microcirculation of the lower limbs (LL) of diabetics is influenced by hyperglycemia and several factors (hypertension, obesity, dyslipidemia) leading to the functional and later the structural changes, manifesting as dysregulation of the peripheral blood flow.
Materials and Methods: The study included 39 patients with type 2 diabetes, and the same number of the control group. The digital photoplethysmography (PPG) was used for assessment of the peripheral circulation with reflectance mode, sensing from the 1st and 2nd toe of the LL after acclimatisation of the patient in the supine position. The subjects were also asked to refrain from smoking, to avoid drinks containing caffeine and using of medicaments with vasodilatator function at least 2 hours before examination.
Results: The pulse amplitudes and the peak times of the PPG curves were significantly higher in diabetic group than in the control group. The mean pulse amplitudes in diabetics were in the range of 0.69 % 0.86 %, the pulse peak time in the range of 140 - 154 ms. The mean pulse amplitudes in the control group were in the range of 0.37 0.54 %, the mean pulse peak time were in the range of 120 - 133 ms. The PPG findings of the LL were symmetrical (non-significant t-test). We have not found a correlation between the PPG records and duration, compensation of diabetes, age, glycemia, blood pressure, dyslipidemia, smoking and obesity.
Conclusion: This simple-to-use technique shows the increased total skin microcirculation in diabetic patients. Microvascular shunting of blood presenting in peripheral nerves and in the skin of diabetic feet are responsible for reduced hyperemia response to any inflammatory process with the increased susceptibility for inquiring the diabetic foot infection.
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Gianluca Rigatelli, Fabio Dell’Avvocata, Marco Zuin, Sara Giatti, Khanh Duong, Trung Pham, Nguyen Si Tuan, Dobrin Vassiliev, Ramesh Daggubati and Thach Nguyen
been investigated in the standard coronary artery bifurcation. Which is the ideal technique in the LM bifurcation scenario independent of the provisional or dual stenting techniques? As designing a randomized trial evaluating the outcomes of such different techniques in a homogeneous population of LM disease is conceptually impossible and economically expensive, computational fluid dynamic (CFD) analysis,[ 9 ] which has been applied in many fields of cardiovascular medicine, may give at least a suggestion on the impact of such techniques on flow physiology and may
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I Skornova, M Samos, R Simonova, J Zolkova, L Stanciakova, L Vadelová, T Bolek, L Urban, F Kovar, J Stasko, P Galajda, P Kubisz and M. Mokan
 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Alfonso F, Macaya C, Bass TA, Costa MA. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 2007; 49: 1505 - 1516
 Fedor M, Samoš M, Šimonová R., et al. Monitoring the Efficacy of ADP Inhibitor Treatment in Patients With Acute STEMI Post-PCI by VASP-P Flow Cytometry Assay. Clin Appl Thromb Hemost. 2015; 21: 334 – 338.
 Lhermusier T, Lipinski MJ, Tantry US, Escarcega RO, Baker N, Bliden KP et al