Mojca Tuta, Nina Boc, Erik Brecelj, Mirko Omejc, Franc Anderluh, Ajra Secerov Ermenc, Ana Jeromen Peressutti, Irena Oblak, Bojan Krebs and Vaneja Velenik
or with the presence of EMVI or extramesorectal lymph nodes involvement on magnetic resonance imaging (MRI) were considered candidates for TNT. Later on two more indications for this treatment selection were added: N2 disease and the distance £ 1 mm of tumor or lymph nodes from mesorectal fascia (MRF).
The main objective of the present study is to evaluate efficiency and toxicity of TNT treatment in LARC with high risk factors for local or distant recurrence in Slovenia.
Patients and methods
This prospective observational study included
Ming-Jun Fan, Shu-Mei Liang, Peng-Juan He, Xing-Bo Zhao, Ming-Jiang Li and Feng Geng
surgery, radiotherapy, chemotherapy and hormone therapy for early-stage diseases. 5 However, therapeutic efficiency of above treatments was extremely limited, hence searching for potential therapeutic targets in EAC become urgent.
Tumor suppressive role of dual-specificity phosphatase 6 (DUSP6) in cancers is suggested to act through ERK/MAPK signaling pathway. Intracellular ERK/MAPK signaling pathway is involved in a variety of cancer transformation as well as their tumorigenesis such as breast cancer 10 , lung cancer 11 , ovarian cancer 12 , pancreatic cancer. 13
Jerneja Varl, Urska Ivanus, Ziva Pohar Marinsek, Tine Jerman, Anja Ostrbenk Valencak, Mario Poljak and Veronika Kloboves Prevodnik
intraepithelial neoplasia grade 2 and 3 Eur J Gynaecol Oncol 2012 33 261 4 PMID: 22873095
8 de Cremoux P, Coste J, Sastre-Garau X, Thioux M, Bouillac C, Labbe S, et al. Efficiency of the Hybrid Capture 2 HPV DNA test in cervical cancer screening. A study by the French Society of Clinical Cytology. Am J Clin Pathol 2003; 120: 492-9. doi: 10.1309/XFUC-PP6M-5XUA-94B8 14560561 10.1309/XFUCPP6M5XUA94B8
de Cremoux P Coste J Sastre-Garau X Thioux M Bouillac C Labbe S et al Efficiency of the Hybrid Capture 2 HPV DNA test in cervical cancer screening. A
Poonam Yadav, Hima B. Musunuru, Jacob S. Witt, Michael Bassetti, John Bayouth and Andrew M. Baschnagel
helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy. Med Phys 2010; 37: 1350-9. doi: 10.1118/1.3326965 Rao M Yang W Chen F Sheng K Ye J Mehta V et al Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy Med Phys 2010 37 1350 9 10.1118/1.3326965
27 Matuszak MM, Yan D, Grills I, Martinez A. Clinical applications of volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 2010; 77: 608-16. doi: 10.1016/j.ijrobp.2009
Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Luigi Camera, Salvatore Tafuto, Antonio Avallone, Andrea Belli, Paola Incollingo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo
tumor biology. 60 DCE-MRI should be used to assess microvascular structures. 61 , 62 The DCE-MRI can be assessed semi-quantitatively or quantitatively. Bol et al . 63 evaluated the role of DCE-MRI to assess the therapy in a murine model, showing that DCE-MRI-derived parameters predict peptide uptake better than the “contrast amount-related” parameters. Consequently, DCE-MRI elucidates the correlation between vascular characteristics, peptide delivery and therapy efficacy, and may predict targeting efficiency. 63 Huh et al . 64 tested, in a clinical study, DCE
Primoz Petric, Robert Hudej, Peter Rogelj, Mateja Blas, Barbara Segedin, Helena Logar and Johannes Dimopoulos
-spin-echo sequence with high sampling efficiency (SPACE) for high spatial resolution imaging: initial clinical experiences. Invest Radiol 2005; 40 : 754-60.
Fütterer JJ, Yakar D, Strijk SP, Barentsz JO. Preoperative 3T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequence. Eur J Radiol 2008; 65 : 66-71.
Kim H, Lim JS, Choi JY, Park J, Chung YE, Kim MJ, et al. Rectal cancer: comparison of accuracy of local-regional staging with two- and three
Elham Raeisi, Seyed Aghamiri, Azin Bandi, Negar Rahmatpour, Seyed Firoozabadi, Sedigheh Kafi-Abad and Lluis Mir
The antitumor efficiency of combined electrochemotherapy and single dose irradiation on a breast cancer tumor model
Background. The aim of this study was to investigate the antitumor effectiveness of electrochemotherapy with cis-platin combined with suboptimal radiotherapy doses. Tumor radiosensitization was evaluated on large invasive ductal carcinoma tumors in Balb/C mice.
Materials and methods. Tumors of an average volume of 630 mm3 were treated with cisplatin, electric pulses, radiotherapy, electrochemotherapy, alone as well as in appropriate combinations. Tumors were irradiated with Cobalt-60 γ-rays at doses 3 Gy and 5 Gy in combination with electrochemotherapy using cisplatin. Controls included each of the treatments alone as well as the combination of the radiotherapy with electric pulses alone or with cisplatin alone. Antitumor effectiveness was evaluated by tumor growth delay, tumor-doubling time, inhibition ratio and the objective response rates.
Results. As anticipated, electrochemotherapy was more effective than the treatment with cisplatin alone or the application of the electric pulses alone. When treatments were combined with tumor irradiation at either 3 or 5 Gy, the combination with electrochemotherapy was more effective: at 5 Gy, 2 animals out of 8 were in complete remission 100 days later. In general the higher 5 Gy dose of γ-radiation was more effective than the lower one of 3 Gy.
Conclusions. The results of our study demonstrate that irradiation doses, 3 Gy or 5 Gy, increase the antitumor effectiveness of electrochemotherapy with cisplatin on invasive ductal carcinoma tumors. Good antitumor results were achieved in experimental tumors with a size comparable to clinical lesions, demonstrating that this three-modality combined treatment is useful for the treatment of large lesions even at sub-optimal radiotherapy doses.
Cancer is becoming a major public health issue as patients enjoy longer survivals than ever before due to the introduction innovative but expensive drugs in the clinic. In addition, the ageing of the population in Greece is expected to increase the absolute incidence of cancer. The National Health System should rapidly and efficiently adapt to the new challenges, including increased pharmaceutical costs. Resources ought to be allocated rationally and efficiently while maintaining adequate coverage for the insured population. Economising due to large-scale operations should be pursued by the governmental single payor (EOPYY), so that affordable coverage remains feasible. Establishment of mechanisms to deal with new and very costly drugs should be put in place. The major changes in anchor oncologic hospitals are needed in order to play a role as regional leaders in oncologic care, including merging of similar divisions, subspecialisation of services and promotion of clinical research. These major centres could coordinate a host of satellite oncology services in other urban hospitals and in the provinces. In addition, joint operations in training and patient care should be pursued with major private centres, without mutual mistrust or obsolete inflexibilities. The current financial crisis represents an excellent opportunity for revisioning and restructuring oncologic care in Greece, taking into account the societal needs and based on flexibility and efficiency.
Kyriakos Souliotis, Eirini Agapidaki and Manto Papageorgiou
alcohol tax cuts in Finland in 2004. Addiction. 2009;104(4):554-63. Epub 2009/04/02.
 Combe CG. Impact of the financial crisis on health research financing: Towards a new model? Expert Review of Pharmacoeconomics and Outcomes Research. 2009;9(4):321-4.
 Gemmill MC, Thomson S, Mossialos E. What impact do prescription drug charges have on efficiency and equity? Evidence from high-income countries. International Journal for Equity in Health. 2008;7.
 Levit KR, Mark TL, Coffey RM, Frankel S, Santora P, Vandivort-Warren R, et al. Federal
type worldwide. At the time of diagnosis, 3–52% of head and neck squamous cell carcinoma (HNSCC) patients are malnourished. During treatment, malnutrition is already present in 44–88% of patients. Various studies have been conducted to evaluate the role of easy-to-obtain measures of nutritional status in HNC cancer patients.
Aim : This study aims to critically summarize and discuss the currently available clinical data on the efficiency of easily obtainable nutritional status assessment tools, such as weight loss and Bioimpedance analysis (BIA) measures in the