Background: Myocardial revascularization procedures have undergone important developments over the last decades, which led to a major shift in current clinical practice and therapeutic guidelines across the world. Bare metal and drug-eluting stents present several limitations, all centered on the concept of disturbed coronary hemodynamics after implantation, which can be surpassed by bioresorbable vascular scaffolds (BVS). BVSs are fourth-generation stents used in coronary revascularization procedures, but despite all the promising initial results published on their efficiency, several clinical trials have reported unsatisfactory results, and the main explanation was accredited to improper implantation method. Shear stress is a central element of intravascular homeostasis; it controls vascular remodeling, as well as the development, progression, and destabilization of atheromatous plaques. This study aims to assess the role of in-stent flow hemodynamics (evaluated by computational determination of shear stress via coronary CT imaging) in predicting the clinical evolution following BVS implantation.
Material and methods: This case-control observational study will include patients with BVSs implanted at least 12 months prior to randomization. Each patient will undergo a complete evaluation of the demographic and clinical characteristics, cardiovascular risk factors, and imaging acquisitions via coronary CT angiography, based on which the endothelial shear stress will be calculated before and after BVS implantation. Post-processing of CT imaging data will evaluate the shear stress and the composition of the coronary plaques along the entire coronary tree. The primary endpoint will be the major adverse cardiovascular events (MACE) in patients with altered vs. non-altered BVS-related shear stress, and the secondary endpoints will comprise evaluating the rate of progression of stent resorption and progression of shear stress alteration.
Conclusions: The findings of the STAFF study can be extremely useful in clinical practice for providing an answer to a key question that is still under debate: why do BVSs fail and how can we prevent this?.
impacting stem cell mobilization failure rate and efficiency in multiple myeloma in the area of novel therapies: experience at Memorial Sloan Kattering Cancer Center. Bone Marrow Transplantation . 2013;48:1033-1039. 9. Worel N, Rosskopf K, Neumeister P, et al. Plerixafor and granulocyte-colony-stimulating factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a named patient program. Transfusion . 2011
II malocclusions. Eur J Orthod . 1999;21(5):491-496. 10. Martins DR, Tibola D, Janson G. Effects of intrusion combined with anterior retraction on apical root resorption. Eur J Orthod . 2012;34(2):170-175. 11. Sunku R, Roopesh R, Kancherla P, Perumalla KK, Yudhistar PV, Reddy VS. Quantitative digital subtraction radiography in the assessment of external apical root resorption induced by orthodontic therapy: a retrospective study. J Contemp Dent Pract . 2011;12(6):422-428. 12. Kinzinger GS, Fritz UB, Sander FG, Diedrich PR. Efficiency of a pendulum appliance for
, Rapon C, Poindessous F, et al. The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomized, double-blind, controlled study. Anaesthesia 2014; 69: 46-52. doi: 10.1111/anae.12495 16. Adam F, Chauvin M, Du Manoir B, Langlois M, Sessler DI, Fletcher D. Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty. Anesth Analg 2005; 100: 475-480. doi: 10.1213/01.ANE.0000142117.82241.DC 17. Laskowski K, Stirling A, McKay WP, Lim HJ. A systematic review of intravenous ketamine for
impairs adipose tissuederived stem cell function and efficiency in promoting wound healing. Wound Repair Regen . 2013;21:543-553. 37. Mesimäki K, Lindroos B, To˝rnwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg . 2009;38:201-209. 38. Garcia-Olmo D, Herreros D, Pascual M, et al. Treatment of enterocutaneous fistula in Crohn’s disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion. Int J Colorectal Dis . 2009;24:27-30. 39. Rodriguez-Menocal L
postoperative shivering: a meta-analysis. J Int Med Res 2016; 44: 1174-1181. doi: 10.1177/0300060516668776 46. He K, Zhao H, Zhou HC. Efficiency and safety of ondansetron in preventing postanaesthesia shivering. Ann R Coll Surg Engl 2016; 98: 358-366. doi: 10.1308/rcsann.2016.0152 47. Li M, Hu X, Tan Y, Yang B, Li K, Tang Z . Meta-analysis of randomized controlled trials on the efficacy and safety of ondansetron in preventing postanesthesia shivering. Int J Surg 2016; 35: 34-43. doi: 10.1016/j.ijsu.2016.09.009 48. Jo YY, Kim YB, Lee D, Chang YJ, Kwak HJ. Implications of