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Epidemiol 2012, 175:144–153. 20. Key TJA, Pike MC: The dose-effect relationship between ‘unopposed’ estrogens and mitotic rate: its general role in explaning and predicting endometrial cancer risk. Brit JCancer 1988, 57:205–212. 21. Dickson RB, Lippman ME: Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma. Endocr Rev 1987, 8:29–43. 22. Braekevelt EB, Lau P, Tague B, Popovic S, Tittlemier SA. Effect of cooking on concentrations of β-estradiol and metabolites in model matrices and beef. J Agric Food Chem 2011, 59:915–920. 23

Fe(III) in Caco-2 cells. J Zhejiang Univ Sci B 2008, 9, 707–712. 15. Lee Y.J., Lim S.S., Baek B.J., An J.M., Nam H.S., Woo K.M., Cho M.K., Kim S.H., Lee S.H.: Nickel(II)-induced nasal epithelial toxicity and oxidative mitochondrial damage. Environ Toxicol Pharmacol 2016, 42, 76–84. 16. Lu H., Shi X., Costa M., Huang Ch.: Carcinogenic effect of nickel compounds. Mol Cell Biochem 2005, 279, 45–67. 17. Mazzotti F., Sabbioni E., Ponti J., Ghiani M., Fortaner S., Rossi G.L.: In vitro setting of dose-effect relationships of 32 metal compounds in the Balb/3T3 cell line

., Sabbioni E., Ponti J., Ghiani M., Fortaner S., Rossi G.L.: In vitro setting of dose-effect relationships of 32 metal compounds in the Balb/3T3 cell line, as a basis for predicting their carcinogenic potential. ATLA 2002, 30, 209–221. 11. Meek B., Doull J.: Pragmatic challenges for the vision of toxicity testing in the 21 st century in a regulatory context: another Ames test? or a new edition of “the Red Book”?. Toxicol Sci 2009, 108, 19–21. 12. Mendel R.R.: Cell biology of molybdenum. Biofactors 2009, 35, 407–468. 13. Mendel R.R., Bittner F.: Cell biology of