D. Micháliková, B. Tyukos Kaprinay, B. Lipták, K. Švík, L. Slovák, R. Sotníková, Š. Bezek and Z. Gáspárová
ANOVA – Analysis of variance
HDL-cholesterol – high-density lipoprotein cholesterol
HFD – high-fat diet
HFFD – high-fat-fructose diet
HTG – hypertriacylglycerolemic
LDL-cholesterol – low-density lipoprotein cholesterol
LTP – long-term potentiation
MetS – metabolic syndrome
n – number
TC – total cholesterol
TG – triacylglycerols
 Alfaro F. J.: Lioutas V. A., Pimentel D. A., Chung C. C., Bedoya F., Yoo W. K., Novak V.: Cognitive decline in metabolic syndrome is linked to
Donatella Verbanac, Željan Maleš and Karmela Barišić
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Mirza Bojić, Željan Maleš, Andrea Antolić, Ivana Babić and Maja Tomičić
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Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation
The objective of the present work was to formulate a self-emulsifying drug delivery system (SEDDS) for simvastatin, which is widely used in the treatment of hypercholesterolemia and dyslipidemia as an adjunct to diet. Simvastatin SEDDS were formulated using a 1:1 (V/V) mixture of diesters of caprylic/capric acids and polyglycolyzed glycerides with varying concentrations of polyoxy castor oil and C8/C10 mono-/diglycerides. The developed SEDDS were evaluated for turbidimetry, droplet size analysis, drug content and in vitro diffusion profiles. In vivo performance of the optimized formulation was evaluated in rats using pharmacodynamic marker parameters like plasma total cholesterol (CH), triglycerides (TG) and high-density lipoprotein (HDL-CH) for 21 days. SEDDS containing 9.1% (m/m) simvastatin and 23.0% (m/m) of each excipient showed minimum mean droplet size (124 nm) and optimal drug diffusion. This test formulation showed significant reduction in plasma CH and TG (around 5-fold and 4-fold, respectively), while HDL-CH concentration was markedly higher (2-fold) compared a reference simvastatin suspension formulation after oral administration for 21 days of study. Test formulation has shown enhanced pharmacodynamic performance compared to reference formulation in rats. The study illustrated the potential of simvastatin SEDDS for oral administration and its biopharmaceutic performance.
E. E. Itoandon, V. A. Nwachukwu, O. L. Erukainure, O. O. Lasore and P. N. Nwagala
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