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Effect of high-fat-fructose diet on synaptic plasticity in hippocampus and lipid profile of blood serum of rat: pharmacological possibilities of affecting risk factors

Abbreviations ANOVA – Analysis of variance HDL-cholesterol – high-density lipoprotein cholesterol HFD – high-fat diet HFFD – high-fat-fructose diet HTG – hypertriacylglycerolemic LDL-cholesterol – low-density lipoprotein cholesterol LTP – long-term potentiation MetS – metabolic syndrome n – number TC – total cholesterol TG – triacylglycerols References [1] Alfaro F. J.: Lioutas V. A., Pimentel D. A., Chung C. C., Bedoya F., Yoo W. K., Novak V.: Cognitive decline in metabolic syndrome is linked to

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Hippocampal electrophysiological responses and changes in oxidative stress marker and serum lipid profile to pharmacological and non-pharmacological treatments of high-fat-fructose diet induced metabolic syndrome

, Solfrizzi V, Seripa D, Capurso C, Santamato A, Sancarlo D, Vendemiale G, Pilotto A, Panza F: Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer’s disease. Ageing Res Rev 1. 2010; 9:399–417. [12] Govindaraj J, Sorimuthu Pillai S: Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: Streptozotocin-induced diabetic rats. Mol Cell Biochem . 2015, 404:143–159. [13] Grundy SM, Barlow CE, Farrell SW, Vega GL, Haskell WL: Cardiorespiratory

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Nutrition – facts and myths

REFERENCES 1. Prospective Urban Rural Epidemiology (PURE) study investigators, Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study, Lancet 390 (2017) 2050–2062; https://doi.org/10.1016/S0140-6736(17)32252-3 2. M. Apostolopoulou, K. Michalakis, A. Miras, A. Hatzitolios and C. Savopoulos, Nutrition in the primary and secondary prevention of stroke, Maturitas 72 (2012) 29–34; https://doi.org/S0378-5122(12)00076-X 3. GBD 2017 Diet

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Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs

. Bulotta, Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies, Pharmacol. Res. 142 (2019) 77–86; https://doi.org/10.1016/j.phrs.2019.01.045 27. J. Delgado-Lista, P. Perez-Martinez, J. F. Alcala-Diaz, A. I. Perez-Caballero, F. Gomez-Delgado, F. Fuentes, G. Quintana-Navarro, F. Lopez-Segura, A. M. Ortiz-Morales, N. Delgado-Casado, E. M. Yubero-Serrano, A. Camargo, C. Marin, F. Rodriguez-Cantalejo, P. Gomez-Luna, J. M. Ordovas, J. Lopez-Miranda and F. Perez-Jimenez, CORonary Diet Intervention

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Beneficial effects of baicalein on a model of allergic rhinitis

. Ethnopharmacol. 153 (2014) 197–206; http://doi.org/10.1016/j.jep.2014.02.010 17. Z. F. Li, X. M. Xia, C. Huang, S. Zhang, J. Zhang and A. J. Zhang, Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis, Hepatobiliary Pancreat. Dis. Int . 8 (2009) 201–208; http://doi.org/10.1111/j.1523-5378.2009.00663.x 18. H. G. Xin, B. B. Zhang, Z. Q. Wu, X. F. Hang, W. S. Xu, W. Ni, R. Q. Zhang and X. H. Miao, Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steato

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Antithrombotic activity of flavonoids and polyphenols rich plant species

. K. S. Krogholm, L. Bredsdorff, P. Knuthsen, J. Haraldsdóttir and S. E. Rasmussen, Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet, Eur. J. Clin. Nutr. 64 (2010) 432–435; http://doi.org/10.1038/ejcn.2010.6 53. I. Palomo, A. Concha-Meyer, M. Lutz, M. Said, B. Sáez, A. Vásquez and E. Fuentes, Chemical characterization and antiplatelet potential of bioactive extract from tomato pomace (byproduct of tomato paste), Nutrients 11 (2019) Article ID 456 (10 pages); https://doi.org/10.3390/nu

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Endothelial dysfunction in experimental models of metabolic syndrome − effect of fructose

rats. Pharmacol Rep. 2008;60:127–138. [4] Kaprinay B, Lipták B, Slovák L, et al. Hypertriglyceridemic rats fed high fat diet as a model of metabolic syndrome. Physiol Res. 2016; 65:S515-S518. [5] Kitagawa S, Sameshima E, Yamaguchi Y, Kwon Y, Shinozuka K, Kunitomo M. Comparison of the eff ects of hypercholesterolaemia on relaxation responses in aortas of spontaneously hypertensive rats and Dahl salt-sensitive rats. Clin Exp Pharmacol Physiol. 1995;22(suppl):S251-S253. [6] McCulloch AI, Bottrill FE, Randall MD, Hiley CR. Characterization and

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Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation

Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation

The objective of the present work was to formulate a self-emulsifying drug delivery system (SEDDS) for simvastatin, which is widely used in the treatment of hypercholesterolemia and dyslipidemia as an adjunct to diet. Simvastatin SEDDS were formulated using a 1:1 (V/V) mixture of diesters of caprylic/capric acids and polyglycolyzed glycerides with varying concentrations of polyoxy castor oil and C8/C10 mono-/diglycerides. The developed SEDDS were evaluated for turbidimetry, droplet size analysis, drug content and in vitro diffusion profiles. In vivo performance of the optimized formulation was evaluated in rats using pharmacodynamic marker parameters like plasma total cholesterol (CH), triglycerides (TG) and high-density lipoprotein (HDL-CH) for 21 days. SEDDS containing 9.1% (m/m) simvastatin and 23.0% (m/m) of each excipient showed minimum mean droplet size (124 nm) and optimal drug diffusion. This test formulation showed significant reduction in plasma CH and TG (around 5-fold and 4-fold, respectively), while HDL-CH concentration was markedly higher (2-fold) compared a reference simvastatin suspension formulation after oral administration for 21 days of study. Test formulation has shown enhanced pharmacodynamic performance compared to reference formulation in rats. The study illustrated the potential of simvastatin SEDDS for oral administration and its biopharmaceutic performance.

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A current view of the diagnostics and treatment of phenylketonuria in Slovakia

References [1] Strnová, J.: Hyperphenylalaninaemiae v Buchanec, J, a kol.: Vademékum pediatra. Martin, Osveta. 2001; 649-652. [2] Hyánek, J., et al.: Maternal hyperphenylalaninemia in a population of healthy Czech women. 18 years experience with mass screening, diet therapy and metabolic monitoring. Čas. Lék. čes., 1996; 135, 50: 87-90. [3] Procházková D., Konečná P., Kozák L., Hrabincová E., Severová J., Vinohradská H., Hrstková H: Maternální fenylketonurie (PKU) v regionu Moravy. Čsl. Pediat., 60, 2005; 5:251-256. [4] Ürge, O., Strnová

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Cola millenii Leaf Ethyl Acetate Extract: Fourier Transform Infrared (FTIR) Spectroscopy; Modulatory Effect on Serum Indices and Redox Biomarkers

] American Cancer Society (ACS). Body weight and cancer risk. 2015, www.cancer.org. Accessed December 23, 2015 [5] Asif M. A brief study of toxic effects of some medicinal herbs on kidney. Adv Biomed Res. 2012, 1: 44. [6] Burkil, H.M., 1985. Royal Botanic Gardens; Kew. [7] Chowdhury P, Soulsby M. Lipid peroxidation in rat brain is increased by simulated weightlessness and decreased by a soyprotein diet. Ann Clin Lab Sci. 2002, 32 (2): 188-192. [8] Cunha LCS, de Morais SAL, Martins CHG, Martins MM, Chang R, de

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