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Pyruvate Dehydrogenase Complex Deficiency: An Unusual Cause of Recurrent Lactic Acidosis in a Paediatric Critical Care Unit

of 14.87. This was suggestive of pyruvate dehydrogenase complex deficiency (PDCD) ( Table 1 ). A skeletal muscle biopsy showed low levels of activated PDC and PDC/E3 ratio ( Table 1 ) as well as a pyruvate dehydrogenase and mitochondrial complex panel testing positive for pyruvate dehydrogenase alpha 1 (PDHA1) gene mutation confirming the diagnosis of PDCD. The patient was given a trial of a ketogenic diet (KD) which did not result in an elevation of lactate levels ( Figure 2 ). He remained on prolonged mechanical ventilation secondary to the development of acute

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Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Introduction Hippocrates, the “Father” of modern medicine, was convinced that disease was a result of multiple factors, including the patient’s lifestyle, environmental forces and diet. Accordingly, as these are unique for every individual, treatment should be focused on the individual. He stated that because the organism acts as one, it should be treated as one, and not as individual parts of a bigger system. In recent times, a new form of medicine has become increasingly exercised, namely personalised medicine (PM) and is efficacious in many medical

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Anti-platelet Therapy Resistance – Concept, Mechanisms and Platelet Function Tests in Intensive Care Facilities

;81:1627-31. 64. Součková L, Opatřilová R, Suk P, et al. Impaired bioavailability and anti-platelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR). Eur J Clin Pharmacol. 2013;69:309-17. 65. Ogu CC, Maxa JL. Drug interactions due to cytochrome P450. Proc (Bayl Univ Med Cent). 2000;13:421-3. 66. Pascoe MC, Howells DW, Crewther DP, et al. Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment. Front Neurol. 2014

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Critical Care Aspects of Gallstone Disease

pancreatitis: a randomized prospective study Ann Surg 2010 251 615 9 107 Moraes JM, Felga GE, Chebli LA, et al. A full solid diet as the initial meal in mild acute pancreatitis is safe and result in a shorter length of hospitalization: results from a prospective, randomized, controlled, double-blind clinical trial. J Clin Gastroenterol. 2010;44:517-22. Moraes JM Felga GE Chebli LA A full solid diet as the initial meal in mild acute pancreatitis is safe and result in a shorter length of hospitalization: results from a prospective, randomized, controlled

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