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A new diagnostic perspective – hyperglycemia in pregnancy – as of the year, 2014

References 1. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care, 2014 Jan; 37 Suppl 1: 81-90. 2. Barbour L.A. et al.: Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care, 30, 112-19, 2007. 3. Ben-Haroush A., Yogev Y., Hod M.: Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med, 21[2], 103-13, 2004. 4. Briana D.D., Malamitsi-Puchner A.: Reviews

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Cognitive decline affects diabetic women

References: 1. McCrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet 2012; 379: 2291-2299. 2. Prasad S, Sajja RK, Naik P, Cucullo L. Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview. J Pharmacovigil 2014; 2: 125. 3. Chmiel-Perzyńska I, Perzyński A, Urbańska EM. Experimental diabetes mellitus type 1 increases hippocampal content of kynurenic acid in rats. Pharmacol Rep. 2014; 66: 1134-1139. 4. Murray AM, Barzilay JI, Lovato JF et al. Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes

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Flozins, inhibitors of type 2 renal sodium-glucose co-transporter – not only antihyperglycemic drugs

References 1. Bhatia K. et al.: Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data. World J. Diabetes, 5, 399, 2014. 2. Chao E., Henry R.: SGLT2 inhibition - a novel strategy for diabetes treatment. Nature Rev. Drug Discov., 9, 551, 2010. 3. Diamant M., Morsink L.: SGLT2 inhibitors for diabetes: turning symptoms into therapy. Lancet, 382, 917, 2013. 4. Endocrine Today. http://www.healio.com/endocrinology/diabetes/(...)sglt2-inhibitors

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Abnormal Levels of Inflammatory and Oxidative Stress Markers in Patients with Arterial Hypertension and Diabetes Mellitus

Summary

Individuals with hypertension and diabetes mellitus are at high risk of cerebrovascular and cardiovascular morbidity and mortality. Recent advances in the multifactorial pathophysiology of atherogenesis provide important information about the complex interrelations between traditional risk factors, inflammation and oxidative stress in mediating all stages of atherosclerosis. The objective of the study was to determine if some inflammatory and oxidative stress markers in patients with arterial hypertension and diabetes mellitus differ from those in healthy age-matched controls. Our results revealed a significant difference in blood pro/antioxidant activities in hypertensive diabetics and the controls. The investigation of inflammatory and oxidative stress markers along with traditional risk factors proves useful in complex assessment of vascular risk and primary prophylaxis of cerebrovascular and cardiovascular events.

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Risk Factors for Coronary Artery Diseases: A Study Among Patients With Ischemic Heart Disease in India (Kerala)

Summary

Coronary artery disease (CAD) is a condition that develops due to accumulation of atherosclerotic plaque in the epicardial coronary arteries, leading to myocardial ischemia. It is the leading cause of death worldwide and is a common complex disease. A study was carried out in a group of 496 patients with acute coronary syndrome or with angiographic or stress test evidence for coronary artery disease, admitted to the Department of Cardiology at Lourdes Heart Institute and Neuro Centre during the period June-August 2012. The risk factors studied were hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking and family history of CAD. The results demonstrated that in both males and females of the Indian population studies, diabetes and dyslipidemia were major risk factors for CAD, while hypertension was not a major risk factor. Therefore, early detection and treatment of diabetes mellitus and dyslipidemia play a vital role in prevention of CAD in Indian population.

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The blood resistin level in patients with DM2, depending on the duration of the disease

; 409: 307-12. 17. Tokuyama Y. et al.: Serum resistin level is associated with insulin sensitivity in Japanese patients with type 2 diabetes mellitus. Metabolism, 2007; 56 (5): 693-698. 18. Vozarova De Courten B. et al.: High serum resistin is associated with an increase in adiposity but not worsening of insulin resistance in Pima Indian. Diabetes, 2004; 53 (9): 1279-1284.

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Levels Of Resistin And Visfatin In Patients With Metabolic Syndrome

.1111/j.1749-6632.2010.05875.x. 5. Dogru T, Sonmez A, Tasci I, Bozoglu E. Yilmaz MI, Gene H. at al. Plasma resistin levels in patients with newly diagnosed untreated type 2 diabetes mellitus and impaired glucose tolerance. Diabetes Res Clin Pract. 2007;76 (1):2-7. 6. Norata GD, Ongari M, Garlaschelli K, Raselli S, Grigore L, Catapano AL. Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur J Endocrinol. 2007;156(2):279-84. 7. Utzschneider K, Carr D, Tong J, Wallace T, Hull R, Zrika S at al. Resistin is not associated with

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Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

Reference 1. Ajiboye BO, Oloyede HOB, Salawu MO. Antihyperglycemic and antidyslipidemic activity of Musa paradisiaca – based diet in alloxan-induced diabetic rats. Food Sci Nutr. 2018;6:137-45. https://doi.org/10.1002/fsn3.538 2. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus – present and future perspectives. Nat Rev Endocrinol. 2012;8:228-36. https://doi.org/10.1038/nrendo.2011.183 3. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes

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Omentin - a new adipokine with many roles to play

tissue. Biochim. Biophys. Acta, 1732, 1-3, 2005. 27. Schaffler A., Zeitoun M., Wobser H. et al.: Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in humangene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel disease. Cardiovasc. Diabetol., 6, 3, 2007. 28. Senolt L., Polanska M., Filkova M. et al.: Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis. Ann. Rheum. Dis., 69, doi:10.1136/ ard

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Application of mesenchymal stem cells in paediatrics

implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocr J 60(3):347-57, 2013. 22. Introna M., et al.: Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients. Biol Blood Marrow Transplant. 20(3):375-81, 2014. doi: 10.1016/j.bbmt.2013.11.033. 23. Jin J.L., et al.: Safety and efficacy of umbilical cord mesenchymal stem cell therapy in hereditary spinocerebellar ataxia. Curr Neurovasc Res 10

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