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Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus – a single institution experience

Introduction Diabetes mellitus (DM) is known to be an independent risk factor for the development of colorectal cancer (CRC). 1 , 2 The risk of colorectal cancer was estimated to be 27% higher in patients with type 2 DM than in non-diabetic controls. 3 However, it is unclear if the presence of diabetes in patients with CRC is associated with the cancer-specific survival of patients after cancer diagnosis. 4 Some authors found that patients with CRC and diabetes are at greater risk of all-cause and cancer-specific mortality and have worse disease

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Non-invasive, Complex Examination of Micro- and Macrovascular System of Patients with Type 1 Diabetes Mellitus with or Without Vascular Complications

LIST OF ABBREVIATIONS: AIX augmentation index BMI body mass index C control ChF change of flow CV cardiovascular CVD cardiovascular disease DM diabetes mellitus DM I type 1 diabetes mellitus DMC diabetes with complications DMW diabetes without complications FBF forearm blood flow HbA1c Hamoglobin A1c IQR interquartile range IU international unit M median PORH Postocclusive reactive hyperemia PU perfusion unit PWV pulse wave velocity sE-selectin soluble endothelial-leukocyte adhesion molecule 1 sICAM-1 soluble

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Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival

number by in situ hybridization. In summary, scarce and conflicting information exist concerning IGF1R expression impact on survival in advanced NSCLC. There are epidemiological data supporting the biological link between cancer and type 2 diabetes mellitus (T2DM) and the well-known fact that patients with T2DM have an increased risk of cancer and cancer-related mortality. 49 In a recently published study, a higher IGF1R expression - according to the previously mentioned meta-analysis a detrimental prognostic factor in operable NSCLC - was found in early stage NSCLC

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Prognostic Value of Epicardial Fat Thickness as a Biomarker of Increased Inflammatory. Status in Patients with Type 2 Diabetes Mellitus and Acute Myocardial Infarction

Abstract

Introduction: The prognostic value of epicardial fat thickness (EFT) and inflammatory biomarkers such as hs-CRP have not been fully investigated in patients with acute myocardial infarction (AMI) and type 2 diabetes mellitus (DM). The study aim was to assess the correlation between the EFT, the persistence of elevated circulating levels of hs-CRP at 7 ± 2 days after an AMI and the amplitude of the left ventricular (LV) remodeling, in patients with type 2 DM. Methods: The study included 98 patients (45 with type 2 DM and 43 with no DM): Group 1 included 22 low-to-intermediate risk patients (hsCRP <3 mg/l) and Group 2 had 23 high-risk, (hsCRP >3 mg/l) patients. EFT, LV function and remodeling were assessed at baseline and at six months after AMI in both groups. Results: In the diabetic population, the EFT was significantly higher in patients who developed ventricular remodeling as compared with those who did not (8.02 ± 1.80 mm vs. 6.65 ± 2.17 mm, p = 0.02) and significantly correlated with the circulating levels of hs-CRP (r = 0.6251, p <0.0001). The levels of circulating hs-CRP, at baseline, significantly correlated with the RI at six months (r = 0.39, p <0.001). Also, in the diabetic population, the epicardial fat thickness was significantly higher in patients who developed ventricular remodeling as compared with those who did not (8.02 ± 1.80 mm vs. 6.65 ± 2.17 mm, p = 0.02). The epicardial adipose tissue thickness significantly correlated with the circulating levels of hs-CRP (r = 0.6251, p <0.0001), while in the non-diabetic population, EFT was not significantly higher in patients who developed ventricular remodeling as compared with those who did not (71.38 ± 9.09 vs. 67.4 ± 10.17, p = 0.23). Multivariate analysis identified the hs-CRP values (OR: 4.09, p = 0.03) and the EFT (OR: 6.11, p = 0.01) as significant independent predictors for LV remodeling in diabetic population. Conclusions: A larger EFT is associated with a more severe remodeling and impairment of ventricular function in patients with type 2 DM and AMI.

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Response to “Prognostic Value of Epicardial Fat Thickness as a Biomarker of Increased Inflammatory Status in Patients with Type 2 Diabetes Mellitus and Acute Myocardial Infarction”

REFERENCES 1. Opincariu D, Mester A, Dobra M, et al. Prognostic Value of Epicardial Fat Thickness as a Biomarker of Increased Inflammatory Status in Patients with Type 2 Diabetes Mellitus and Acute Myocardial Infarction. Journal of Cardiovascular Emergencies. 2015;1(2):11-18. DOI: 10.1515/jce-2016-0003. 2. Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr. 2009;22(12):1311-1319. quiz 417-8. DOI: 10.1016/j.echo.2009.10.013. 3. Saura D, Oliva MJ, Rodriguez D, et al

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Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma

Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma

Tumors of the Bartholin gland are rare, comprising less than 5% of all vulvar malignancies. Treatment is largely based on that of vulvar and anal squamous cell carcinomas. A case of invasive, grade 4, poorly differentiated squamous cell carcinoma of the Bartholin gland is presented. Our patient, a 47-year-old woman, had a history significant for cervical intraepithelial neoplasia treated with conization, type 2 diabetes mellitus, and tobacco use. The course of treatment included preoperative radiotherapy plus 5-fluorouracil and cisplatin chemotherapy, followed by restaging and posterior exenteration in combination with vaginal reconstruction.

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A case with myasthenia gravis, brain stem multiple infarcts, fracture of vertebrae Th6 and discal hernia to the Th7/Th8

A case with myasthenia gravis, brain stem multiple infarcts, fracture of vertebrae Th6 and discal hernia to the Th7/Th8

Background. We report the case of a patient with myasthenia gravis accompanied with brain stem multiple infarcts, fracture of vertebrae Th6 and discal hernia of the Th7/TH8.

Case report. A 66-year-old male patient, one week prior to the hospitalization showed up complaints of dizziness, nausea, vomiting, numbness of the left side of the face, swallowing difficulty, left side body weakness, right side of the body numbness starting from the nipples and going down to the right leg as well as general fatigue. Six years ago the patient was diagnosed with myasthenia gravis based on electrophysiological investigations, pharmacologic tests and findings of acetylcholine (Ach) receptor antibodies in serum. He was then treated with the following medications: pyridostigmine of 60mg × 5/day, prednisolon of 20 mg (every other day), azathioprine 100mg tid. He was doing well under described therapy. Twenty years ago his left kidney was removed due to calculosis. He had also a sister that suffered of myasthenia gravis and diabetes mellitus.

Conclusions. Myasthenia gravis has a number of symptoms and signs which probaly are in common with stroke-including fatigue, muscle weakness, slurred speach and swallowing difficulty. The reported case supports the opinion that several medical conditions such as brain steam stroke may mimick myasthenia gravis.

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Analysis of risk factors for perifocal oedema after endovascular embolization of unruptured intracranial arterial aneurysms

Abstract

Background. Endovascular embolization is a treatment of choice for the management of unruptured intracranial aneurysms, but sometimes is complicated with perianeurysmal oedema. The aim of our study was to establish incidence and outcomes of perianeurysmal oedema after endovascular coiling of unruptured intracranial aneurysms, and to reveal possible risk factors for development of this potentially serious complication.

Methods. In total 119 adult patients with endovascular embolization of unruptured intracranial aneurysm (performed at Department for Interventional Neuroradiology, Clinical Center, Kragujevac, Serbia) were included in our study. The embolizations were made by electrolite-detachable platinum coils: pure platinum, hydrophilic and combination of platinum and hydrophilic coils. Primary outcome variable was perianeurysmal oedema visualized by magnetic resonance imaging (MRI) 7, 30 and 90 days after the embolization.

Results. The perianurysmal oedema appeared in 47.6% of patients treated with hydrophilic coils, in 21.6% of patients treated with platinum coils, and in 53.8% of those treated with mixed type of the coils. The multivariate logistic regression showed that variables associated with occurrence of perianeurysmal oedema are volume of the aneurysm, hypertension, diabetes and smoking habit. Hypertension is the most important independent predictor of the perianeurysmal oedema, followed by smoking and diabetes.

Conclusions. The results of our study suggest that older patients with larger unruptured intracranial aneurysms, who suffer from diabetes mellitus and hypertension, and have the smoking habit, are under much higher risk of having perianeurysmal oedema after endovascular coiling.

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Epicardial Adipose Tissue – A New Biomarker of Cardiovascular Risk

suspected coronary artery disease. J Nucl Cardiol. 2015;22:325-333. doi: 10.1007/s12350-014-0004-4. 11. Tanindi A, Erkan AF, Ekici B. Epicardial adipose tissue thickness can be used to predict major adverse cardiac events. Coron Artery Dis. 2015;26:686-691. doi: 10.1097/ MCA.0000000000000296. 12. Chun H, Suh E, Byun AR, Park HR, Shim KW. Epicardial fat thickness is associated to type 2 diabetes mellitus in Korean men: a cross-sectional study. Cardiovasc Diabetol. 2015;14:46. doi: 10.1186/s12933-015-0210-7. 13. Opincariu D

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Factors Associated with In-hospital Mortality in Patients with Acute Coronary Syndrome

Am Coll Cardiol Intv. 2013;6:115-125. 10. Alonso J, Bueno H, Bardají, A et al. Influence of sex on acute coronary syndrome mortality and treatment in Spain. Rev Esp Cardiol Supl. 2008; 8:8D-22D. 11. Fuster V, Farkouh ME. Coronary Syndromes and Diabetes Mellitus. Circulation. 2008;118:1607-1608. 12. Park JS, Cha KS, Lee DS, et al. Culprit or multivessel revascularisation in ST-elevation myocardial infarction with cardiogenic shock. Heart. 2015;101:1225-1232. 13. Awad HH, Anderson FA Jr, Gore JM et al

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