Adrian Bartos, Caius Breazu, Dana Bartos, Lidia Ciobanu and Calin Mitre
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) improves the prognosis in selected patients with peritoneal surface malignancies but it is an extensive procedure predisposing to major complications. Among them renal toxicity was reported. Severe renal insufficiency is considered a contraindication for this complex procedure. We present a patient with diabetic nephropathy with renal insufficiency KDOQI 3 and peritoneal metastasis from sigmoid adenocarcinoma with a good clinical outcome after CRS with HIPEC, highlighting the anesthetic precautions considered for this particular clinical case.
Alina Cordunean, Roxana Hodaş, Sorin Pop, Nora Rat, Laura Jani, Alexandra Stănescu, Imre Benedek and Theodora Benedek
Engl J Med . 1998;339:229-234.
4. Kornowski R, Mintz GS, Kent KM, et al. Increased restenosis in diabetesmellitus after coronary interventions is due to exaggerated intimal hyperplasia. A serial intravascular ultrasound study. Circulation . 1997;95(6):1366-1369.
5. Mintz GS. Diabetic Coronary Artery Disease. JACC . 2008;52(4):263-265.
6. Scognamiglio R, Negut C, Ramondo A, Tiengo A, Avogaro A. Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 DiabetesMellitus. J Am Coll Cardiol . 2006;47(1):65-71.
7. Srinivasan MP
Alina Cordunean, Roxana Hodas, Edvin Benedek, Lehel Bordi, Imre Benedek and Theodora Benedek
1. Roffi M, Angiolillo DJ, Kappetein AP. Current concepts on coronary revascularization in diabetic patients. Eur Heart J . 2011;32:2748-2757.
2. Srinivasan MP, Kamath PK, Bhat NM. Severity of coronary artery disease in type 2 diabetesmellitus: Does the timing matter. Indian Heart J . 2016;68:158-163.
3. Mintz GS. Diabetic Coronary Artery Disease – How Little We Know and How Little Intravascular Ultrasound Has Taught Us. J Am Coll Cardiol . 2008;52:263-265.
4. McCullough PA, Fazel P, Choi JW. Screening, Diagnosis, and
Márta Germán-Salló, Enikő Nemes-Nagy, Beáta Baróti, Robert Gabriel Tripon and Zoltán Preg
The current guidelines for the diagnosis and treatment of hypertension recommend screening for cognitive impairment in all hypertensive patients as part of the clinical assessment. However, the implementation of this recommendation in clinical practice is still unsatisfactory. We present the case of an elderly hypertensive female patient in order to highlight the importance of screening for cognitive impairment. A patient with a history of poorly controlled hypertension for the last 12 years and recently diagnosed with type 2 diabetes mellitus is admitted complaining of asthenia, dizziness, visual acuity impairment, and difficulty to remember recent information. Cardiovascular imaging showed 70% internal carotid artery stenosis in a neurologically asymptomatic patient. Cognitive testing showed mild cognitive impairment. Retinal imaging identified stage III hypertensive retinopathy accompanied by irreversible end-organ damage due to microvascular changes. At this point brain MRI was performed, which identified both macro- and microvascular brain lesions in the periventricular white matter and sequelae of a former ischemic stroke in the territory of the left posterior cerebral artery. Cognitive testing helped to unmask silent cerebrovascular disease in an otherwise oligosymptomatic hypertensive diabetic patient. Cognitive function testing should be introduced in routine clinical practice in order to help unmask silent cerebrovascular disease.
Marieni Bello, Maria Cirilo Sousa, Gabriel Neto, Leonardo Oliveira, Ialuska Guerras, Romeu Mendes and Nelson Sousa
American Diabetes Association. Diagnosis and classification of diabetesmellitus. Diabetes Care, 2013; 36: 67-74
Becker C, Crow S, Toman J, Lipton C, McMahon DJ, Macaulay W, Siris E. Characteristics of elderly patients admitted to an urban tertiary care hospital with osteoporotic fractures: correlations with risk factors, fracture type, gender and ethnicity. Osteoporosis International, 2006; 17: 410-416
Borg GA. Psychophysical bases of perceived exertion. Medicine and Science in Sports and Exercise
Enikő Nemes-Nagy, Robert Gabriel Tripon, Sándor Pál and Mariana Cornelia Tilinca
The association of multiple autoimmune diseases may represent the main focus of physicians treating patients with such pathology presenting no comorbidities of different etiology. However, autoimmune diseases and side effects of drugs may lead to development of silent health-threatening diseases that should be identified promptly. We present the case of an elderly, obese, Caucasian female patient suffering of autoimmune thyroiditis, rheumatoid arthritis, and psoriasis, who developed arterial hypertension and insulin-treated secondary diabetes mellitus (due to long-term oral corticotherapy) with microvascular end-organ changes. Retinal imaging for capillary anomalies identified mild non-proliferative diabetic retinopathy with apparent diabetic macular edema and hypertensive retinopathy. Laboratory investigations looking for further vascular risk factors revealed zinc deficiency, elevated serum homocysteine levels, and constantly high C-reactive protein concentration. Attention should be payed to the proper investigation of patients with autoimmune diseases, targeting the early diagnosis of microvasculopathies due to autoimmune diseases or possible medication side effects, in order to prevent end-organ damage.
. Greene M.F., Benecerraf B.R.: Prenatal diagnosis in diabetic gravidas: utility of ultrasound and maternal serum alpha-fetoprotein screening. Obstet Gynecol 1991;77:520-524.
8. Albert T.J., Landon M.B., Wheller J.J.: Prenatal detection of fetal anomalies in pregnancies complicated by insulin-dependent diabetesmellitus. Am J Obstet Gynecol 1996;174:1421-1428.
9. Meyer-Wittkopf M., Simson J.M., Sharland G.K.: Incidence of congenital heart defects in fetuses of diabetic mothers: a retrospective study of 326 cases. Ultrasound Obstet Gynecol
. JMIR Diabetes . 2017;2:e7.
5. Wang R, Zhang P, Lv X, et al. Situation of diabetes and related disease surveillance in rural areas of Jilin Province, Northeast China. Int J Environ Res Public Health . 2016;13:538.
6. Gnavi R, Karaghiosoff L, Costa G, Merletti F, Bruno G. Socio-economic differences in the prevalence of diabetes in Italy: the population-based Turin study. Nutr Metab Cardiovasc Dis . 2008;18:678-682.
7. Kaiser A, Vollenweider P, Waeber G, Marques-Vidal P. Prevalence, awareness and treatment of type 2 diabetesmellitus in Switzerland
Agnieszka Maciejewska-Skrendo, Paweł Cięszczyk, Jakub Chycki, Marek Sawczuk and Wojciech Smółka
oxidation as well as non-oxidative glucose metabolism. PGC1α and PGC1β are powerful regulators of mitochondrial biology in the heart, acting by broadly regulating gene expression from both nuclear and mitochondrial genomes – in this way PGC1α andPGC1β play a critical role in mitochondrial metabolism. The allelic variations in their genes increase the risk of the development of 2 diabetesmellitus and obesity. It has been shown that the PPARGC1A rs8192678 AA genotype (that is characteristic for PGC1α proteins with Ser in the 482 position) is more favorable for Russian
Norbert A. Szekeres, Zsuzsánna Jeremiás, Árpád Olivér Vida, Orsolya Mártha and Daniel Porav-Hodade
, hyperlipidemia, diabetesmellitus and depression in men with erectile dysfunction. J Urol . 2004;171:2341-2345.
5. Solomon H, Man JW, Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart . 2003;89:251-253.
6. Feldman HA, Johannes CB, Derby CA, et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med . 2000;30:328-338.
7. Fung MM, Bettencourt R, Barrett-Connor E. Heart disease risk factors predict erectile dysfunction 25