Juan José Marín-Peñalver, Iciar Martín-Timón and Francisco Javier del Cañizo-Gómez
exacerbate acute illness. This results in a vicious cycle of uncontrolled blood sugar and worsening of the disease. [ 3 ]
Randomized clinical trials in no critically and critically ill patients with type 2 diabetesmellitus (T2DM) proved that by improving glycemic control, we could reduce all of them. Consequently, the hospital objectives for T2DM patients must include improved glycemic control (preventing hypo- and hyperglycemia) so that they can reduce hospital complications, systemic infections, hospital stay, and hospitalization cost and provide an effective
Diabetesmellitus (DM) and its complications cost billions of dollars to the taxpayer. According to the American Diabetes Association (ADA), the cost of DM to the tax payer was $245 billion in 2012. This is a change from $174 billion in 2007 when the cost was last examined. Majority of the cost is incurred in the inpatient care of diabetes. The problem gets compounded by the increasingly elderly population that is diabetic. [ 1 ] In the United States, more than 25% of elderly patients are diabetic and the number is rapidly increasing. Shrestha
Obesity is now assuming epidemic proportions worldwide. Elevated arterial pressure is a frequent complication of excess body weight, and both obesity and hypertension are components of insulin-resistance syndrome [ 1 , 2 ] . Many obese hypertensive patients tend to develop type-2 diabetesmellitus, which further increases their cardiovascular risk. While lifestyle modification is the key to weight and blood pressure reduction, pharmacological intervention remains essential to lowering blood pressure to target levels in obese patients with
Bennur Esen, Emel Sağlam Gokmen, Mahmut Kaya, Burak Ozkan and Ahmet Engin Atay
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease which is associated with progressive deterioration of renal functions. [ 1 ] End-stage renal disease (ESRD) is observed in 25% of patients aged <50 years and 50% of patients aged <60 years. [ 2 ] Insulin resistance (IR) accompanies diabetesmellitus (DM), hypertension, dyslipidemia, glucose intolerance, and hyperuricemia in metabolic and cardiovascular disorders (CVDs). [ 3 ] There are controversial reports in terms of IR in patients with ADPKD
Hamda Houssein Ahmed, David De Bels, Rachid Attou, Patrick M. Honore and Sebastien Redant
, congenital enzyme deficiencies, thiamine deficiencies and diabetesmellitus, [ 1 ] and also alcohol abuse, which may induce a lactic acid under-use or an increased production. [ 2 , 3 ] The authors describe a rare complication of type 1 DiabetesMellitus (T1DM), leading to a major and persistent expression of a type B lactic acidosis during ketoacidosis.
Rationale of the study: The author would like to report a rare clinical entity that could bring a message to the scientific community.
A 16-year-old female patient diagnosed T1DM from the age of
Armando Peixoto, Marco Silva, Rui Gaspar, Rui Morais, Rosa Ramalho, Guilherme Macedo and João Santos-Antunes
] low compliance, [ 4 ] and hypersecretion of hydrochloric acid. [ 5 ] However, the evidence is scarce for other factors, particularly the impact biotype, [ 6 ] smoking, [ 7 ] diabetesmellitus (DM), [ 8 ] and previous treatment failure. In particular, it is unknown whether the body mass index (BMI) influences in a clinically significant way the pharmacokinetics and/or pharmacodynamics of the drugs involved in eradication (in particular, the proton pump inhibitors and antibiotics). Furthermore, to date, studies are in most cases controlled in relation to the
Zain Majid, Muhammad Manzoor ul Haque, Muhammad Danish Ashraf, Nasir Hassan Luck and Ameet Kumar Lalwani
history of liver disease, diabetesmellitus, abdominal trauma, use of oral contraceptive pills, alcohol intake, changes in her mental status or the use of any over the counter medications. Her general physical examination was unremarkable.
Her initial workup showed her viral markers to be negative (HbsAg, anti HCV). Laboratory investigations were all normal apart from a low serum hemoglobin (9.1 g/dL), low serum albumin (2.8 g/dL) and a slightly raised ESR (25 mm/h). Her liver function tests were slightly deranged with a total bilirubin 0.93 IU/L, direct bilirubin 0
Shahinul Alam, Mohammad Jahid Hasan, Md. Abdullah Saeed Khan, Mahabubul Alam and Nazmul Hasan
) anthropometric information including weight, height, BMI and waist circumference, c) glycemic status and insulin resistance (HOMA-IR), d) liver biochemistry (alanine transaminase [ALT], aspartate aminotransferase [AST], gamma-glutamyltrasferase [GGT]), e) liver histopathology (NAS score and fibrosis), and f) other comorbid conditions like diabetesmellitus (DM), dyslipidemia, hypertension, and so on. Similar data were collected at the end of the follow-up for 1 year. Patients were followed-up monthly for the first 3 months and three monthly up to 1 year. During the study
Guoxin Wang, Xiang Liu, Sheng Wang, Nan Ge, Jintao Guo and Siyu Sun
Nieto J et al EUS-guided gastroenterostomy: a multicenter study comparing the direct and balloon-assisted techniques Gastrointest Endosc 2018 87 1215 21
61 Zhu L, Mo Z, Yang X, Liu S, Wang G, Li P, et al. Effect of laparoscopic Roux-en-Y gastroenterostomy with BMI<35 kg/m(2) in type 2 diabetesmellitus. Obes Surg 2012;22:1562–7. 10.1007/s11695-012-0694-0 22692669
Zhu L Mo Z Yang X Liu S Wang G Li P et al Effect of laparoscopic Roux-en-Y gastroenterostomy with BMI<35 kg/m(2) in type 2 diabetesmellitus Obes Surg 2012 22
Herbert Spapen, Johan van Laethem, Maya Hites, An Verdoodt, Marc Diltoer and Patrick M. Honoré
were enrolled in this study. Patient characteristics and outcome were depicted in Table 1 . All patients were endotracheally intubated, ventilated in pressure-controlled mode and initiated on CVVH at the start of COL therapy. The mean age was 57 ± 14 years. APACHE II score at ICU admission was 26 ± 11, which corresponds to a predicted mortality of approximately 55%. The most frequent comorbidities were congestive heart failure/ischemic cardiomyopathy ( n = 5) and type 2 diabetesmellitus ( n = 3). One patient had chronic kidney disease. All except one patient