Dittakarn Boriboonhirunsarn, Tripop Lertbunnaphong and Kamaitorn Tientong
1. American Diabetes Association. Diagnosis and classification of diabetesmellitus (Position Statement). Diabetes Care. 2009; 32(Suppl 1):S62-7.
2. Expert Committee on the Diagnosis and Classification of DiabetesMellitus. Report of the Expert Committee on the Diagnosis and Classification of DiabetesMellitus. Diabetes Care. 1997; 20:1183-97.
3. The American College of Obstetricians and Gynecologists. Committee opinion number 504: Screening and diagnosis of gestational diabetesmellitus. Obstet
Type 1 diabetesmellitus (T1D) is a chronic disease caused by an immune-mediated destruction of b-cells, resulting in lifelong dependence on exogenous insulin [ 1 ]. The incidence of newly diagnosed T1D in children and adolescents has been increasing rapidly worldwide [ 2 ]. In 1993, the Diabetes Control and Complications Trial (DCCT) study established that in patients with T1D, early near-normalization of blood glucose with glycated hemoglobin (HbA 1c ) <7.0% prevents or delays progression of long-term micro-vascular complications [ 3 ]. However, optimizing
Xiu-lan Zou, Jun Yang, Jian-ming Yang, Yan-qun Liu, Wen Wang, Jun Zheng, Bao-hua Ma and Fang-yuan Chen
Background: Diabetic cardiomyopathy is an important complication of type 2 diabetics. The role of immunoinflammation, immunity, and diet has not been adequately clarified.
Objective: We investigated the relationships between diabetic cardiomyopathy and immuno-inflammation, as well as immunity and diets.
Methods: Sixty Sprague-Dawley (SD) male rats were included in this study, from which 12 were randomly selected as the normal control group (group A) and of which the remaining 48 were considered as the type 2 diabetes mellitus (T2DM) model group. Group A was fed with common diets and the T2DM model group, with high-glucose diets (by adding 20% cane sugar, 10% lard, and 2.5% cholesterol into a 67.5% common diet). After 4-week feeding, the T2DM model group was randomly allocated into three groups according to the diet, highfat diet group (group B), common diet group (group C), and low-fat diet group (group D). All the three groups were then fed for another 10 weeks. At the end of the experiment, body weight, random blood glucose levels, and cardiac weight were measured. Left ventricular tissue was obtained for light microscopy and electron microscopy. Deposits of immunoglobulin G (IgG) in myocardium were identified by immunohistochemistry. Serum levels of high-sensitivity C-reactive protein (hs-CRP) were determined using the enzyme-linked immunosorbent assay (ELISA). All data were statistically analyzed.
Results: The serum level of hs-CRP was significantly higher in groups B, C, and D, than in the control group. Therefore, IgG deposits among cardiac muscle cells were observed in all the model groups, significant deviations were noted in group A (p <0.01) and IgG deposits were less in group D than in groups B and C (p <0.01).
Conclusion: Immuno-inflammation participates in the development of T2DM and diabetic cardimyopathy. Immune injury can be alleviated following dietary interference.
predicted new cases 2005-2020: a multicentre prospective registration study. Lancet. 2009; 373:2027-33.
4. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetesmellitus in adolescent and children. J Pediatr. 2005; 146:693-700.
5. Likitmaskul S, Wacharasindhu S, Rawdaree P, Ngarmukos C, Deerochanawong C, Suwanwalaikorn S, et al. Thailand diabetes registry project: type of diabetes, glycemic control and prevalence of microvascular complications in children and adolescents with diabetes. J Med Assoc Thai. 2006; 89 (Suppl 1):S10
convenience sampling to select 59 cases of elderly patients with fracture and diabetesmellitus, who attended the Department of Orthopedic Surgery in a hospital of Tai’an City from September 2016 to February 2017. The patients ranged in age from 60 years to 86 years, with an average age of 77.5 years. Among them, there were six cases of fibular fracture, 11 cases of tibial fracture, nine cases of femoral fracture, 27 cases of radius fracture, and 12 cases of ulnar fracture. The history of diabetes ranged from 17 years to 1 year, and the patients’ fasting blood glucose
Diabetesmellitus (DM) is a chronic disease that occurs when the pancreas does not produce enough insulin or the body is unable to utilize insulin, resulting in hyperglycemia. 1 Prevalence of diabetes Indonesia (20-79 years) shows 12 million at 2010. Estimates of diabetes in Indonesia increasing become 12 million in 2030. 2 Diabetes can lead to complications of stroke, coronary heart disease, arterial disease, foot ulcer, visual impairment, and amputation. 3 , 4 , 5 , 6
One of the complications that affect the quality of life is foot
Diabetesmellitus (DM) is a metabolic disease resulting from impaired metabolism of carbohydrates, lipids, and proteins. DM can be categorized into 2 major types; type 1 DM (insulin dependent) and type 2 DM (not insulin dependent). The main causes of this disease are a lack of either insulin production or response to insulin, or both, leading to chronic hyperglycemia [ 1 ]. Long-lasting hyperglycemia can cause diabetic complications such as vascular disease, diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and sexual dysfunction [ 2 , 3
Kanisshanone Chuayruang, Jiruth Sriratanaban, Narin Hiransuthikul and Sompongse Suwanwalaikorn
Diabetesmellitus (DM) is a chronic disease and a major public health concern in Thailand as well as globally. Its complications, such as neuropathy, retinopathy, stroke, heart disease, and kidney disease lead to both individual and social problems [ 1 ]. A previous study revealed that the number of adults with DM (aged 20–79 years) worldwide was 285 million in 2010, but expected to increase to approximately 439 million by 2030; 69% of which would be in developing countries [ 2 ]. The number of suspected cases in Thailand has increased dramatically. In 2009
study. Consenting consecutive patients on a stable dose of insulin for >3 months were recruited for the study. For the purpose of this study, “stable dose of insulin” was defined as the dose that is adjustable in an outpatient clinical setting and not requiring admission into a ward. Patients with gestational diabetesmellitus and cognitive impairment were excluded.
Patients attending the diabetes clinics were invited to participate after providing verbal and written information about the study. Those who signed the voluntary consent form were