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Syphacia muris infection delays the onset of hyperglycemia in WBN/Kob-Lepr fa rats, a new type 2 diabetes mellitus model

pancreatitis prior to diabetes onset in WBN/Kob-Lepr fa rats. J. Vet. Med. Sci. , 74: 65 - 70. DOI: 10.1292/jvms.11-0168 Cooke, A., Tonks, P., Jones, F.M., 0'Shea, H., Hutchings, P., Fulford, A.J.C., Dunne, D.W. (1999): Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice. Parasite Immunol. , 21: 169 - 176. DOI: 10.1046/j. 1365-3024.1999.00213.x Daniele, G., Guardado, M. R., Winnier, D., Fiorentino T. V., Pengou, Z., Cornell, J., Andreozzi, F., Jenkinson, C., Cersosimo, E., Federici, M., Tripathy, D., Folli, F

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High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection

alban , P. A., D onath , M. Y. (2002): Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. , 110: 851 – 860. DOI: 10.1172/jci15318 N agakubo , D., S hirai , M., N akamura , Y., K aji , N., A risato , C., W atanabe , S., T akasugi , A., A sai , F. (2014): Prophylactic effects of the glucagon-like Peptide-1 analog liraglutide on hyperglycemia in a rat model of type 2 diabetes mellitus associated with chronic pancreatitis and obesity. Comp. Med. , 64: 121 – 127 O kamoto , M., T aira , K

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GLP-1 localisation and proglucagon gene expression in healthy and diabetic mouse ileum

Introduction Diabetes mellitus (DM) is a metabolic disease characterised by hyperglycaemia because of insulin resistance or pancreatic β-cell failure ( 10 ). Glucagon-like peptide-1 (GLP-1) is an incretin hormone that mainly stimulates insulin secretion after oral food intake ( 11 ). It is a polypeptide synthesised from proglucagon, which is encoded by the glucagon or proglucagon gene (GCG). In addition to being used for synthesising GLP-1, proglucagon, which contains 160 amino acids, is used for synthesising glucagon, glicentin, oxyntomodulin, glicentin

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Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats

Introduction The development and progression of diabetes and its complication are linked to chronic inflammatory conditions. Increased expressions of systemic inflammatory markers are associated with the pathogenesis of insulin resistance and type 2 diabetes ( 12 ). Macro- and microvascular complications of diabetes are mediated by inflammatory processes, thus prevention or treatment of inflammation will inhibit, retrogress, and/or ameliorate the complications of diabetes mellitus (DM) ( 14 ). Most antidiabetic drugs have been reported to possess anti

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Genetic testing for lymphedema-distichiasis syndrome

sclerosing glomerulopathy), diabetes mellitus ( 2 ), varicose veins, cleft palate, extradural cysts, congenital heart defects (tetralogy of Fallot, ventricular septal defects), ocular findings, such as photophobia, exotropia, droopy eyelids (ptosis), ectropion and cataracts ( 3 , 4 ). The estimated prevalence of LD is currently unknown. The clinical diagnosis of LD is based on: primary lymphedema (chronic swelling of the extremities caused by intrinsic dysfunction of the lymphatic vessels); distichiasis (aberrant and/or extra row of eyelashes originating from the

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The Antidepressants and the Metabolic Syndrome

-faceted effects. Oncogene. Nature Publishing Group; 2012;32:1475–87. 14. Kun IZ, Kun I, Kun IZJ. Metabolikus szindróma, diabetes mellitus és a rosszindulatú daganatok. Orvostudományi Értesítő. 2015;88:7–18. 15. Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J. Clin. Psychiatry. 2010;71:1259–72. 16. Bak M, Fransen A, Janssen J, van Os J, Drukker M. Almost all antipsychotics result in weight gain: a meta-analysis. PLoS One. 2014;9:e94112. 17. Neal MJ (ford. Laszlovszky István). Rövid farmakológia. B

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Nutraceutical prospective: The synergetic mechanism of action of inositols and resveratrol on metabolic syndrome

, neural tube closure and the prevention of neural tube defects Birth Defects Res 2017 Jan 30 109 2 68 80 7 Farren M, Daly N. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017 Jun;40(6):759-763. 10.2337/dc16-2449 28325784 Farren M Daly N The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial Diabetes Care 2017 40 6 759 763 8 Brown J, Crawford TJ. Dietary supplementation with myo

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Anti-inflammatory and analgesic activities of methanol extract of Helianthus annuus Linn. (Asteraceae) leaf

practice with suspected anti-inflammatory activity ( 7 ). Helianthus annuus Linn. belong to the family Asteraceae. It has wide folkloric uses in the ethnomedical practice of South Eastern Nigeria, India and Pakistan ( 8 ). The plant is used in the treatment of pyrexia, inflammation, worm infestation, diabetes mellitus and other stomach problems ( 9 ). The phytochemical screening of the leaf have reported the presences of alkaloids, saponins, glycosides, terpenes, sterols, tannins and flavonoids ( 10 , 11 ). Bioactive compounds such as Helivypolide G, annuionones a, b

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Comparison of in vitro antioxidative activities of crude methanolic extracts of three species of Passiflora from greenhouse using DPPH, ABTS and FRAP methods

.bjp.2017.07.005 62. Ramaiya SD, Bujang JS, Zakaria MH. Assessment of total phenolic, antioxidant, and antibacterial activities of Passiflora species. Sci World J 2014; 2014: ID 167309, 10 pages. doi: 63. Colomeu TC, Figueiredo D, Cazarin CB, Schumacher NS, Marostica MR Jr., Meletti LM, et al. Antioxidant and anti-diabetic potential of Passi-flora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice). Int Immunopharmacol 2014; 18:106-115. doi:

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Unusual clinical course of trichinellosis with relapse


During an outbreak of trichinellosis in Eastern Slovakia in 2008, 16 people were hospitalized, including 10 patients having specific anti-Trichinella antibodies. The disease relapse was seen in a 68-year-old woman two weeks after her discharge from hospital, where she was treated with albendazole and prednisone for 10 days. Clinical symptoms of trichinellosis, eosinophilia, elevated CRP and LDH levels were observed again with recorded elevation of aminotransferase levels during the relapse. Herein we discuss a potential cause of unusual relapse of trichinellosis with liver damage in a female patient with type II diabetes mellitus.

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