alban , P. A., D onath , M. Y. (2002): Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest. , 110: 851 – 860. DOI: 10.1172/jci15318
N agakubo , D., S hirai , M., N akamura , Y., K aji , N., A risato , C., W atanabe , S., T akasugi , A., A sai , F. (2014): Prophylactic effects of the glucagon-like Peptide-1 analog liraglutide on hyperglycemia in a rat model of type 2 diabetesmellitus associated with chronic pancreatitis and obesity. Comp. Med. , 64: 121 – 127
O kamoto , M., T aira , K
Diabetesmellitus (DM) is a metabolic disease characterised by hyperglycaemia because of insulin resistance or pancreatic β-cell failure ( 10 ). Glucagon-like peptide-1 (GLP-1) is an incretin hormone that mainly stimulates insulin secretion after oral food intake ( 11 ). It is a polypeptide synthesised from proglucagon, which is encoded by the glucagon or proglucagon gene (GCG). In addition to being used for synthesising GLP-1, proglucagon, which contains 160 amino acids, is used for synthesising glucagon, glicentin, oxyntomodulin, glicentin
Samuel Okwudili Onoja, Samuel Chukwuneke Udem and Aruh Ottah Anaga
The development and progression of diabetes and its complication are linked to chronic inflammatory conditions. Increased expressions of systemic inflammatory markers are associated with the pathogenesis of insulin resistance and type 2 diabetes ( 12 ). Macro- and microvascular complications of diabetes are mediated by inflammatory processes, thus prevention or treatment of inflammation will inhibit, retrogress, and/or ameliorate the complications of diabetesmellitus (DM) ( 14 ). Most antidiabetic drugs have been reported to possess anti
Yeltay Rakhmanov, Paolo Enrico Maltese, Stefano Paolacci, Carla Marinelli and Matteo Bertelli
sclerosing glomerulopathy), diabetesmellitus ( 2 ), varicose veins, cleft palate, extradural cysts, congenital heart defects (tetralogy of Fallot, ventricular septal defects), ocular findings, such as photophobia, exotropia, droopy eyelids (ptosis), ectropion and cataracts ( 3 , 4 ).
The estimated prevalence of LD is currently unknown.
The clinical diagnosis of LD is based on: primary lymphedema (chronic swelling of the extremities caused by intrinsic dysfunction of the lymphatic vessels); distichiasis (aberrant and/or extra row of eyelashes originating from the
Kolcsár Melinda, Gáll Zsolt, Bába László-István and Kun Imre Zoltán
-faceted effects. Oncogene. Nature Publishing Group; 2012;32:1475–87.
14. Kun IZ, Kun I, Kun IZJ. Metabolikus szindróma, diabetesmellitus és a rosszindulatú daganatok. Orvostudományi Értesítő. 2015;88:7–18.
15. Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J. Clin. Psychiatry. 2010;71:1259–72.
16. Bak M, Fransen A, Janssen J, van Os J, Drukker M. Almost all antipsychotics result in weight gain: a meta-analysis. PLoS One. 2014;9:e94112.
17. Neal MJ (ford. Laszlovszky István). Rövid farmakológia. B
Antonio Malvasi, Andrea Tinelli, Domenico Baldini, Rossana G. Iannitti and Bernard Fioretti
, neural tube closure and the prevention of neural tube defects Birth Defects Res 2017 Jan 30 109 2 68 80
7 Farren M, Daly N. The Prevention of Gestational DiabetesMellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017 Jun;40(6):759-763. 10.2337/dc16-2449 28325784
Farren M Daly N The Prevention of Gestational DiabetesMellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial Diabetes Care 2017 40 6 759 763
8 Brown J, Crawford TJ. Dietary supplementation with myo
Samuel O. Onoja, Glory C. Onyebuchi, Ifeoma I. Ijeh and Maxwell I. Ezeja
practice with suspected anti-inflammatory activity ( 7 ).
Helianthus annuus Linn. belong to the family Asteraceae. It has wide folkloric uses in the ethnomedical practice of South Eastern Nigeria, India and Pakistan ( 8 ). The plant is used in the treatment of pyrexia, inflammation, worm infestation, diabetesmellitus and other stomach problems ( 9 ). The phytochemical screening of the leaf have reported the presences of alkaloids, saponins, glycosides, terpenes, sterols, tannins and flavonoids ( 10 , 11 ). Bioactive compounds such as Helivypolide G, annuionones a, b
Z. Paraličová, P. Dubinský, P. Kristian and P. Jarčuška
During an outbreak of trichinellosis in Eastern Slovakia in 2008, 16 people were hospitalized, including 10 patients having specific anti-Trichinella antibodies. The disease relapse was seen in a 68-year-old woman two weeks after her discharge from hospital, where she was treated with albendazole and prednisone for 10 days. Clinical symptoms of trichinellosis, eosinophilia, elevated CRP and LDH levels were observed again with recorded elevation of aminotransferase levels during the relapse. Herein we discuss a potential cause of unusual relapse of trichinellosis with liver damage in a female patient with type II diabetes mellitus.