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9. Veljkovic S. Chronicle of the Medical Faculty in Belgrade 1920–2010 – History, people and events 1863-1920-2010. [In Serbian]. Faculty of Medicine-Belgrade, 2010: 1024.
10. Savicevic M. Teachers of the Faculty of Medicine-Belgrade – from the foundation until the 1950s, second edition. [In Serbian]. Faculty of Medicine-Belgrade, 2003: 434.
11. Lazarevski M, Nikodijević B, Velkov K, Caparoski R, Glavaš E. Establishment and 40-years development of the Faculty of Medicine in Skopje (1947–1987) [In Macedonian] In: Lazarevski M
1. Neill US. Publish or perish, but at what cost? J Clin Invest. 2008; 118: 2368.
2. Bilić-Zulle L. Research integrity - a cornerstone of existence and development of science [In Croatian]. Biochemia Medica. 2007; 17: 143-50.
3. Donev D. Scientific and Publication Ethics and Misconduct. [In Macedonian]. Vox Medici. Dec 2012; 77: 235-40. Available at: http://www.lkm.org.mk/VoxMedici/77.pdf Accessed: June 30, 2014.
4. Donev D. Principles and ethics in scientific communication in biomedicine. Acta Informatica Medica. 2013; 21 (4): 228
Marija Cvetkova, Iskra Bitoska, Kostadin Poposki, Dejan Jakimovski and Mile Bosilkovski
Brucella thyroiditis represents an extremely rare focal form of brucellosis. In this case report we describe a 55 years old male, diagnosed with brucellosis and peripheral arthritis with subsequent development of acute thyroiditis. The symptoms duration consistent with brucellosis started two weeks before establishing the diagnosis. Only a day after diagnosis and initiation of antibrucellar treatment, acute non-suppurative thyroiditis suddenly manifested. Thyroiditis was diagnosed with clinical inspection and confirmed by ultrasound investigation. With the appropriate antibrucellar treatment, complete cure of thyroid affection was reached in ten days and the patient remained well during the follow-up period of two and a half years. In conclusion, in brucellosis endemic regions brucellosis should be included in the diagnostic consideration in patients with acute non-suppurative thyroiditis. Early recognition and adequate treatment of brucella thyroiditis results in favorable outcome.
Pappas M. Efthymios, Mpournaka Spiridoula, Katopodis Periklis, Chardalias Andreas, Tsakas Sotiris, Eleftheriadis Theodoros, Papachristou Evangelos, Katopodis P. Konstantinos and Goumenos S. Dimitrios
Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, immune deficiency also exists in CKD patients. The number and the activity of Natural Killer cells (NK-cells) are influenced by the biocompatibility of various dialysis membranes. In this study we investigated the effect of dialysis modality and membrane type on NK-cell number and on phagocytic activity of neutrophils in patients on different dialysis methods.
Sixty patients were included in the study and divided in three groups of 20 patients each. Patients on conventional hemodialysis using Low Flux membrane (cHD-LF) were included in Group I, patients on conventional dialysis using High Flux membrane (cHD-HF) were included in Group II and patients treated by on-line hemodiafiltration with High Flux polysulphone membrane (on-line HDF) were included in Group III. Native immunity was investigated using the number of NK-cells and the phagocytic activity of neutrophils.
NK-cells count was significantly lower (p<0.001) in the three groups of dialyzed patients in comparison to healthy subjects. However, no significant difference was observed in the NK-cells count among patients treated by conventional dialysis using Low or High Flux membrane and patients treated by on-line hemodiafiltration. Similarly, although the phagocytic activity of neutrophils was significantly decreased in all patients on dialysis (p<0.001), no difference related to the dialysis modality or membrane performance was observed. A strong positive correlation was recognized between parathormone blood levels and number of NK-cells (r=0.305, p<0.01).
In conclusion, an impairment of the native immunity represented by NK cell number and phagocytic activity of neutrophils is observed in patients on dialysis. Dialysis modality and membrane performance do not influence the native immunity of dialyzed patients. However, parathormone blood levels are possibly involved in the development of immune system disturbances in such patients.
Marija Petrushevska, Kristina Pavlovska, Jovanka Laskova, Pance Zdravkovski and Marija Glavas Dodov
Nanotechnology presents a modern field of science that in the last twenty-five years plays a dominant role in the biomedicine. Different analytical methods are used for evaluation of the physico-chemical properties of nanoparticles including chromatography, electrophoresis, X-ray scattering, spectroscopy, mass spectrometry, zeta potential measurement and microscopy on which this article will focus.
Herein, we present novel application of the long-established TEM technique that is focused on characterization and evaluation of various nanoparticles in development of drug delivery systems.
Transmission electron microscopy images were taken of samples from native nanoparticles, nanoparticles labeled using stannous chloride labeling procedure, inorganic silica nanoparticles loaded with budesonide and native micelles and micelles carrier of anticancer drug camptothecin. In the case of radiolabeled nanoparticles, beside for nanoparticle characterization, TEM technique was used to confirm the stability of the nanoparticles after radiolabeling. Furthermore, the porous structure of hybrid silica particles loaded with budesonide was examined under TEM.
Transmission electron microscopy technique offers exceptional benefits for nanoparticle characterization. Additionally, the necessity of ultrastructural analysis demonstrates the potential of TEM in the field of nanomedicine. Hence, the long-established and well-known TEM has been only partially exploited and offer researchers very detailed images of specimens at microscopic and nano scale.
Aneta Atanasovska Stojanovska, Saska Todoroska, Mirjana Popovska, Ilijana Muratovska and Linda Zendeli Bedzeti
.FEMS Microbiol Lett. 2009 Jul; 296(1): 45–51. doi: 10.1111/j.1574-6968.2009.01629.x. Epub 2009 May 7.
24. Suzuki N, Nakano Y, Yoshida A, Yamashita Y, Kiyoura Y. J Clin Microbiol. 2004 Aug; 42(8): 3827–30. Real-time TaqMan PCR for quantifying oral bacteria during biofilm formation. [J Clin Microbiol. 2004]
25. Price RR, Viscount HB, Stanley MC, Leung KP. Targeted profiling of oral bacteria in human saliva and in vitro biofilms with quantitative real-time PCR. Biofouling. 2007; 23(3-4): 203–13.
26. Park SN, Lim YK, Kook JK. Development of quantitative real
Doncho Donev, Momir Polenakovic and Nada Pop-Jordanova
1. Lazarevski M, Nikodijević B, Velkov K, Čaparoski R, Glavaš E. Establishment and 40-year development of the Faculty of Medicine in Skopje (1947-1987). [In Macedonian]. In: Lazarevski M., Editor-in-Chief. Faculty of Medicine in Skopje 1947-1987. Faculty of Medicine, Ss Cyril and Methodius University, Skopje. Skopje, 1987: 15-50.
2. Nikodijević B. Establishment of the Faculty of Medicine in Skopje in 1947. [In Macedonian]. In: Nikodijević B., Antova N., Šumkovski M., eds. Almanac of the First Generation of Students at the Faculty of
Marija Sholjakova, Jordan Nojkov, Zorka Nikolova-Todorova, Mirjana Shosholcheva, Andrijan Kartalov and Biljana Kuzmanovska
1. Rupreht J, Keys TE. Anesthesia. Its Origins and Its Mission, ch.1.1. In: Rupreht J, et al. Eds. Anesthesia. Essays in its History. Springer-Verlag, Berlin, Heidelberg. 1985: 7.15.
2. Juki. M. Anaesthesiology activities in Croatia from the first ether narcosis in Zadar in 1847 to 2008. Acta med-hist Adriat. 2010; 8(2): 365.76.
3. Soban D, Andonov V, Lalevic P, Ribari. L, Staji. A. The development of Modern Anesthesia in Yugoslavija, ch.4.15. In: Rupreht J, et al. Eds. Anesthesia. Essays in its History. Springer-Verlag, Berlin, Heidelberg
. Such facts were collected while studying the literature in the field of modern education, while observing actual events that take place in high school.
The following documents made the empirical basis of the study:
– The concept of long-term social and economic development of the Russian Federation for the period up to 2020 (the Order of the Government of the Russian Federation dated November 17, 2008 No. 1662-p);
– The report of Oxford University Research Centre “International Trends in Higher Education 2016-2017”;
– The speech of the head of Sberbank
It is obvious that contemporary man is suffering. His sufferings often seem pointless and causeless. Modern science more and more comes to reveal and acknowledge that human sufferings have a psychosomatic basis. In some of the cases, these sufferings are noogenic neuroses. They do not originate from the psychological dimension but from the noological or spiritual one of human existence. Тhe pointlessness of life is the basic cause for the noogenic neurosis and depression from which the humankind suffers. Hence, the many escapes from such experienced reality into various addictions. Possible way towards healing is to retrieve one’s meaning of life, to strengthen his will to meaning. Religion has always been-and still remains-a powerful and appealing purpose that fulfills the life and being of the believers. This article demonstrates the systematization of the spiritual development of a person presented in a table of the harmony of the ascetic-hesychastic struggle, according which everyone can find his place on the ladder of spiritual development, become aware, and reconciliate the mode of personal struggle according to his spiritual development. The reconciliation of the primary function of the mind with its secondary function-the intellect, is of an essential importance. Contemporary religious psychology do not regard man merely as a biological or a psychological being. The subject matter of research is the human being as a whole, as a spiritual person that is characterized by autonomy, regarding the biological and psychological processes. The importance of understanding the spiritual level of human existence enables holistic approach and experiencing of the human personality as a whole. Furthermore, it offers new perspectives of psychotherapeutic action not only within the range of the classical psychotherapeutic modalities but also within the range of the applied Christian Psychotherapy.