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Early postnatal hypothalamic-pituitary-adrenal axis activity and reduced insulin sensitivity in adult rats

References Bijani S, Najafi Abedi A, Ranjbaran M, Sadeghi Gharajeh Daghi S, Ghoshooni H, Zardooz H, Bourbour Z, Sahraei H. Effects of noise pollution stress during pregnancy on anatomical and functional brain cortex development of the offsprings of NMRI mice. Koomesh 14, 192–199, 2013. Bonner-Weir S. Perspective: postnatal pancreatic beta cell growth. Endocrinology 141, 1926–1929, 2000. Chida Y, Sudo N, Sonoda J, Hiramoto T, Kubo C. Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus–pituitary–adrenal axis. Am J

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Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells

, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol 301, 215–290, 2013. Cao H, Xu Z, Wang J, Cigliano A, Pilo MG, Ribback S, Zhang S, Qiao Y, Che L, Pascale RM, Calvisi DF, Chen X. Functional role of SGK3 in PI3K/Pten driven liver tumor development. BMC Cancer 19, 343, 2019. Chen Y, Sun Z, Qi M, Wang X, Zhang W, Chen C, Liu J, Zhao W. INPP4B restrains cell proliferation and metastasis via regulation of the PI3K

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Micro RNAs: an arguable appraisal in medicine

. Detection and characterization of placental microRNAs in maternal plasma. Clin Chem 54, 482-490, 2008. Corbin R, Olsson-Carter K, Slack F. Th e role of microRNAs in synaptic development and function. BMB Rep 42, 131-135, 2009. Cottonham CL, Kaneko S, Xu L. miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J Biol Chem 285, 35293-35302, 2010.

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Sympathectomized tumor-bearing mice survive longer but develop bigger melanomas

–427, 2006. Grzanna R, Frondoza CG, Otten U. Sympathectomy inhibits growth of a murine plasmacytoma tumor. J Auton Nerv Syst 13, 149–160, 1985. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D’Agostino R, Jr., Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest 123, 874–886, 2013. Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG. Cancer drug resistance: an evolving paradigm. Nat Rev Cancer 13, 714–726, 2013. Horvathova L, Padova A, Tillinger A

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Darapladib inhibits atherosclerosis development in type 2 diabetes mellitus Sprague-Dawley rat model

-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice. Acta Pharmacol Sin 32, 1253–1258, 2011. International Diabetes Federation: IDF Diabetes Atlas (6nd ed.), 2013. Navale AM, Paranjape AN. Role of inflammation in development of diabetic complications and commonly used inflammatory markers with respect to diabetic complications. Int J Pharm Pharm Sci 5, 1–5, 2013. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 148, 852–871, 2012. Silva IT, Mello APQ, Damasceno NRT

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Exposure to a single immobilization or lipopolysaccharide challenge increases expression of genes implicated in the development of Alzheimer’s disease in the mice brain cortex


Objectives. Despite extensive research efforts, mechanisms participating on development of Alzheimer’s disease (AD) are covered only partially. Data from the last decades indicate that various stressors, as etiological factors, may play a role of in the AD. Therefore, we investigated the effect of two acute stressors, immobilization (IMO) and lipopolysaccharide (LPS), on the AD-related neuropathology.

Methods. Adult C57BL/6J mice males were exposed to a single IMO stress or a single intraperitoneal injection of LPS (250 µg/kg body weight). After terminating the experiments, the brains were removed and their cortices isolated. Gene expression of pro-inflammatory cytokines, as well as expression of genes implicated in the AD neuropathology were determined. In addition, mediators related to the activation of the microglia, monocytes, and perivascular macrophages were determined in brain cortices, as well.

Results. In comparison with the control animals, we found increased gene expression of proinflammatory mediators in mice brain cortex in both IMO and LPS groups. In stressed animals, we also showed an increased expression of genes related to the AD neuropathology, as well as positive correlations between genes implicated in AD development and associated neuroinflammation.

Conclusions. Our data indicate that acute exposure to a strong IMO stressor, composed of the combined physical and psychological challenges, induces similar inflammatory and other ADrelated neuropathological changes as the immune LPS treatment. Our data also indicate that cytokines are most likely released from the peripheral immune cells, as we detected myeloid cells activity, without any microglia response. We hypothesize that stress induces innate immune response in the brain that consequently potentiate the expression of genes implicated in the AD-related neuropathology.

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The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals

Receptor A in Sertoli Cells and Germ Cells During Spermatogenesis. Ann N Y Acad Sci 1120, 114−130, 2007. Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell 134, 921-931, 2008. Dufour JM, Kim KH. Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: identification of potential heterodimeric receptors. Biol Reprod 61, 1300−1308, 1999. Eguizabal C, Shovlin TC, Durcova-Hills G, Surani A, McLaren A. Generation of primordial germ cells from

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Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance

and epithelial mesenchymal transformation of high glucose induced-podocytes. Exp Ther Med 16, 1095–1102, 2018. Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY. BMP-responsive protease HtrA1 is differentially expressed in astrocytes and regulates astrocytic development and injury response. J Neurosci 38, 3840–3857, 2018. Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov 5, 586–597, 2015. Contois LW, Akalu A, Caron JM, Tweedie E, Cretu A, Henderson T, Liaw L

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Effect of the autonomic nervous system on cancer progression depends on the type of tumor: solid are more affected then ascitic tumors

, Lutgendorf SK, Sood AK. Neuroendocrine influences on cancer progression. Brain Behav Immun 30 Suppl, S19–25, 2013. Bauman J, McVary K. Autonomic nerve development contributes to prostate cancer progression. Asian J Androl 15, 713–714, 2013. Bayon Lara AM, Landa Garcia I, Alcalde Escribano J, Rodriguez Dapena S, Ortega Medina L, Balibrea Cantero JL. Colonic carcinogenesis in vagotomyzed rats. Rev Esp Enferm Dig 93, 576–586, 2001. Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3, 401–410, 2003. Bjelakovic G, Tasic T

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