Razvoj novih zdravil je dolgotrajen in drag proces, saj celotni postopek od ideje do končnega izdelka običajno zahteva vsaj deset let raziskav in več kot milijardo dolarjev. Z uporabo novih matematičnih pristopov in modernih računalnikov skušamo skrajšati in poceniti predvsem zgodnje faze razvoja, pri čemer nas zanimajo tarčne biološke molekule, ki so vpletene v potek različnih bolezni.
V Laboratoriju za molekularno modeliranje na Kemijskem inštitutu v Ljubljani razvijamo nova matematična orodja za uporabo na področju razvoja novih zdravil. Z algoritmi, ki temeljijo na teoriji grafov in metodah simulacije molekulske dinamike, preučujemo tarčne biološke molekule in pridobivamo pomembne podatke za optimiziranje zgodnjih stopenj razvoja novih zdravil.
professionals and limit excessive medicalization ( 18 ). Alongside the well-documented positive impact of HVs, criticism regarding their involvement in regards to patient safety and quality of care has been recently highlighted ( 19 ). Volunteers have become the second staff in some hospitals, nursing homes and community settings, similar to that composed of health-care professionals; therefore, it has been suggested that data on their experiences and difficulties should be taken into consideration in the development of policies aimed at improving their role ( 2 ). Available
Jan Grosek, Jurij Aleš Košir, Jerica Novak, Mirko Omejc, Aleš Tomažič and Gregor Norčič
both ( 4 ). The prevalence of LARS varies considerably, ranging from 19% to 90% of patients who undergo rectal resections ( 5 , 6 , 7 , 8 ).
Several risk factors have been proposed for the development of LARS following surgery for rectal cancer, including age, female sex, surgical technique (mesorectal excision, intersphincteric resection, type of anastomosis and construction of temporary stoma), prolonged presence of defunctioning ileostomy, neoadjuvant and/or adjuvant therapy, and postoperative complications (anastomosis leak, abscess) ( 9 , 10 ). The level
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Brigita Skela-Savič, Rhoda Macrae, Manuel Lillo-Crespo and Kevin D Rooney
better patient outcomes (health), better system performance (care) and better professional development (learning)’ ( 4 , p. 2). In this respect, quality improvement and change making should become an essential part of healthcare professionals’ work at all levels of the healthcare system ( 5 ). Implementation science and quality improvement efforts share the ultimate goal of improving healthcare quality. However, there are differences. Quality begins with a specific problem in a given healthcare system, while implementation science begins with evidencebased practice
The reflexive recognition of potentials of medical students and trainees: example workshops for tutors and mentors at the medical faculty university of ljubljana
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