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From mathematics to drug development

Od matematike do razvoja zdravil

Razvoj novih zdravil je dolgotrajen in drag proces, saj celotni postopek od ideje do končnega izdelka običajno zahteva vsaj deset let raziskav in več kot milijardo dolarjev. Z uporabo novih matematičnih pristopov in modernih računalnikov skušamo skrajšati in poceniti predvsem zgodnje faze razvoja, pri čemer nas zanimajo tarčne biološke molekule, ki so vpletene v potek različnih bolezni.

V Laboratoriju za molekularno modeliranje na Kemijskem inštitutu v Ljubljani razvijamo nova matematična orodja za uporabo na področju razvoja novih zdravil. Z algoritmi, ki temeljijo na teoriji grafov in metodah simulacije molekulske dinamike, preučujemo tarčne biološke molekule in pridobivamo pomembne podatke za optimiziranje zgodnjih stopenj razvoja novih zdravil.

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Hospital volunteering experiences suggest that new policies are needed to promote their integration in daily care: Findings from a qualitative study

professionals and limit excessive medicalization ( 18 ). Alongside the well-documented positive impact of HVs, criticism regarding their involvement in regards to patient safety and quality of care has been recently highlighted ( 19 ). Volunteers have become the second staff in some hospitals, nursing homes and community settings, similar to that composed of health-care professionals; therefore, it has been suggested that data on their experiences and difficulties should be taken into consideration in the development of policies aimed at improving their role ( 2 ). Available

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Validation of the Slovenian version of the low anterior resection syndrome score for rectal cancer patients after surgery

both ( 4 ). The prevalence of LARS varies considerably, ranging from 19% to 90% of patients who undergo rectal resections ( 5 , 6 , 7 , 8 ). Several risk factors have been proposed for the development of LARS following surgery for rectal cancer, including age, female sex, surgical technique (mesorectal excision, intersphincteric resection, type of anastomosis and construction of temporary stoma), prolonged presence of defunctioning ileostomy, neoadjuvant and/or adjuvant therapy, and postoperative complications (anastomosis leak, abscess) ( 9 , 10 ). The level

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The development of diagnosis related group system in healthcare

, Huijsman R. A four phase development model for integrated care services in the Netherlands. BMC Health Services Research 2009, 9 : 42. Direct Graduate Medical Education. Pridobljeno s spletne strani 30. 4. 2011: http://www.cms.gov/AcuteInpatientPPS/06_dgme.asp Indirect Medical Education. Pridobljeno s spletne strani 30. 4. 2011: http://www.cms.gov/AcuteInpatientPPS/07_ime.asp#TopOfPage Higher Education Funding Council for England. Pridobljeno s spletne strani 30. 4. 2011: http

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Nursing knowledge as a response to societal needs: a framework for promoting nursing as a profession

and practices in EU Member States. Eur J Educ 2004; 39: 69-90. Skela Savič B. Development of nursing care in Slovenia for the needs of society in the future. In: Advancing nursing education: research, quality and innovation. 8 th European Conference of Nurse educators, Portugal 6 th - 9 th October. Lisbon: Fine - European Federation of Nurse Educators: Escola Superior de Enfermagem de Lisboa, 2010: 56. Karkos B, Peters K. A magnet community hospital: fewer barriers to nursing research utilization. J Nurs Adm

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Product liability system in healthcare

/34/ES Evropskega parlamenta in Sveta z dne 10. maja 1999) 2006. Pridobljeno 25. 1. 2011 s spletne strani http://eur-lex.europa.eu/Result.do?direct=yes&lang=sl&where=LB%3A31985L0374&whereihm=Legal+basis%3A31985L0374 Kutnjak J. Civilna odgovornost za zdravila. Pravna praksa 2004; 16(15): 44-5. Pugh C, Pilgerstorfer M. The development risk defence, Knowledge, Discoverability and Creative Leaps. Pridobljeno 25. 3. 2011 s spletne strani: www.oldsquarechambers.co.uk/pdf_articles/3100126.pdf. www

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The development of a consensus definition for healthcare improvement science (HIS) in seven European countries: A consensus methods approach

better patient outcomes (health), better system performance (care) and better professional development (learning)’ ( 4 , p. 2). In this respect, quality improvement and change making should become an essential part of healthcare professionals’ work at all levels of the healthcare system ( 5 ). Implementation science and quality improvement efforts share the ultimate goal of improving healthcare quality. However, there are differences. Quality begins with a specific problem in a given healthcare system, while implementation science begins with evidencebased practice

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Refleksivno prepoznavanje potenciala študentov medicine in specializantov: primer delavnic za tutorje in mentorje na medicinski fakulteti univerze v ljubljani
The reflexive recognition of potentials of medical students and trainees: example workshops for tutors and mentors at the medical faculty university of ljubljana

References 1. Sales CS, Schlaff AL. Reforming medical education: a review and synthesis of five critiques of medical practice. Soc Sci & Med 2010; 70: 1665-1668. 2. Groopman JE. How doctors think. Boston: Houghton Mifflin Co., 2007. 3. Clark JM, Houston TK, Kolodner K, Branch WT, Levine RB, Kern DE. Teaching the teachers: national survey of faculty development in departments of medicine of US teaching hospitals. J Gen Intern Med 2004; 19: 205-214. 4. Steinert Y, Mann K, Centeno A, Dolmans

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Relations of weight status and physical fitness of children in Slovenia

, Williamson DF, Gai, MH. Excess deaths associated with underweight, overweight and obesity. JAMA 2005; 293: 1861-7. 7. Wright CM, Parker L, Lamont D, Craft AW. Implications of childhood obesity for adult health: findings from thousand families cohort study. BMJ 2001; 323: 1280-4. 8. Gallahue DL, Ozmun JC, Goodway JD. Understanding motor development: infants, children, adolescents, adults. Boston: WCB/McGraw-Hill, 2012. 9. Bouchard C. The obesity epidemic: introduction, In: Bouchard C, editor. Physical activity and obesity

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Attachment to Caregivers and Type 1 Diabetes in Children / Navezanost Na Starše in Sladkorna Bolezen Tipa 1 Pri Otrocih

York: Perseus Books Group, 1972. 6. Ainsworth MD. Patterns of infant-mother attachments: antecedents and effects on development. Bull N Y Acad Med 1985; 61: 771-91. 7. Main M, Solomon J. Procedures for identifying infants as disorganized/ disoriented during the Ainsworth strange situation. In: Greenberg MT, Cichetti D, Cummings EM, editors. Attachment in the preschool years: theory, research and intervention. Chicago: University Press, 1990: 121-60. 8. Main M. Introduction to the special section on attachment and

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