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Selenium Deficiency as a Risk Factor for Development of Anemia

;54:454-9. 4. Oldfield JE. Selenium world atlas (Updated edition). Grimbergen: Selenium-Tellurium Development Association (STDA); 2002. 5. Combs GF Jr. Selenium in global food systems. Br J Nutr. 2001;85(5):517-47. 6. Lozanov B, Tzachev K, Kirilov G, Aceva E, Vukov M. [Serum Selenium concentration and thyroid status in pregnant women on the background of systemic iodine supplementation]. Endocrinologia. 2008;13(2):56-64. Bulgarian. 7. Bivolarska A. [Iodine and iron deficiency in risk groups of population in some regions of Southern Bulgaria and influence of

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Experimental Study On The Development Of Tolerance And Withdrawal Syndrome To Pentylenetetrazole-Induced Seizures In Rats Treated With Retigabine


The aim of the study was to evaluate seizure liability in rats against the convulsant pentylenetetrazole (PTZ) during a 14-day treatment with retigabine (RTG). The seizure liability was also studied on the 1st, 2nd and 3rd day after the abrupt determination of its administration. Male Wistar rats were divided in groups of 10 and treated orally for 14 days (1st – 6th group with distilled water, and 7th – 12th group with retigabine (RTG) at a dose of 60 mg/kg bw The tolerance to the anticonvulsant effect of RTG was studied using subcutaneous injection of PTZ (120 mg/kg bw) on the 1th and 14th day. To determine the possible neuronal hyperexcitability on the 1st, 2nd and 3rd day after termination of drug administration, a lower dose of PTZ (65 mg/kg bw) was used. According to our results there was no change in the anticonvulsant activity of RTG during the whole period of treatment. The study on withdrawal syndrome showed slightly decrease of the effect on the first day after the last treatment, but with no significant difference to the controls. The anticonvulsant effect of RTG on the 2nd and 3rd day was close to that in the control group. Our results showed no development of tolerance on subchronic treatment with RTG. There was no significant change in the neuronal hyperexcitability on the 1st, 2nd and 3rd day after the termination of treatment. Based on these results we can suggest that RTG has no potential to develop withdrawal syndrome.

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Localization Of MMP-2 And MMP-9 In Canine Mammary Gland During Pregnancy

gland development and breast cancer. Science. 2002;296(5570):1046-9. 5. Green K, Lund LR. ECM degrading proteases and tissue remodeling in the mammary gland. BioEssays. 2005;27(9):894-903. 6. Benaud C, Dickson R, Thompson E. Roles of the matrix metalloproteinases in mammary gland development and cancer. Breast Cancer Res Treat. 1998;50(2):97-116. 7. Fata J, Werb Z, Bissell M. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 2004;6(1):1-11. 8. Khokha R, Werb Z. Mammary

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Light Microscopic Study of Renal Morphological Alterations in Spontaneously Hypertensive Rats

Ther Med. 2013;6(5):1243-6. 9. Tylicki L, Rutkowski B. Hypertensive nephropathy: pathogenesis, diagnosis and treatment. Pol Merkur Lekarski. 2003;14(80):168-73. 10. Fioretto P, Mauer M. Histopathology of diabetic nephropathy. Semin Nephrol. 2007;27(2):195-207. 11. Pannarale G, Carbone R, Del Mastro G, Gallo C, Gattullo V, Natalicchio L, et al. The aging kidney: structural changes. J Nephrol. 2010;23(Suppl. 15):S37-40. 12. Okamoto AK. Development of a strain of spontaneously hypertensive rat. Jap Circ J. 1963;27:282-93. 13. Dickhout JG

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Genetic Disorders Affecting Tubulin Cytoskeleton

the basal ganglia and cerebellum. Am J Hum Genet. 2013;92(5):767-73. 12. Yuba-Kubo A, Kubo A, Hata M, Tsukita S. Gene knockout analysis of two gamma-tubulin isoforms in mice. Dev Biol. 2005;282(2):361-73. 13. Poirier K, Lebrun N, Broix L, Tian G, Saillour Y, Boscheron C et al. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet. 2013;45(6):639-47. 14. Brandt R. The tau proteins in neuronal growth and development. Front Biosci. 1996;1:d118-30. 15. Lei P, Ayton S, Moon S, Zhang Q

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Attitudes Of Regular Alcohol Drinking Adolescents To Intersubjective Relations And Everyday Life

;7(4):286-94. 10. Fleming JP, Kellam SG, Brown CH. Early predictors of age at first use of alcohol, marijuana, and cigarettes. Drug Alcohol Depend 1982;9(4):285-303. 11. Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, De Wit H. Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcohol Clin Exp Res. 2010;34(8):1334-45. 12. James LM, Taylor J. Impulsivity and negative emotionality associated with substance use problems and Cluster B personality in college students. Addict Behav. 2007

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Myocardial Infarction And Ischemic Heart Disease In Patients With Acute Ischemic Stroke

Outcomes. 2014;7(1):95-101. 9. Gu L, Liu W, Yan Y, Su L, Wu G, Liang B, et al. Influence of the β-fibrinogen-455G/A polymorphism on development of ischemic stroke and coronary heart disease. Thromb Res. 2014;133(6):993-1005. 10. Iso H, Noda H, Ikeda A, Yamagishi K, Inoue M, Iwasaki M, et al. The impact of C-reactive protein on risk of stroke, stroke subtypes, and ischemic heart disease in middle-aged Japanese: the Japan public health center-based study. J Atheroscler Thromb. 2012;19(8):756-66. 11. Iwasaki K, Haraoka K, Hamaguchi T, Imamura T, Kawada S

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Genetic Polymorphisms, Plasma Levels of Lipoprotein (A) and its Possible Links with Degenerative Aortic Stenosis

. The risk of the development of aortic stenosis in patients with “benign” aortic valve thickening. Arch Intern Med. 2002; 162(20):2345-7. 7. Carabello B, Paulus W. Aortic stenosis. Lancet. 2009;373(9667):956-66. 8. Koleva K, Zlatareva N, Gudev A. [A new look at degenerative aortic stenosis], MP - SSZ. 2007;38(4): 14-9. Bulgarian. 9. Hughes B, Chhoud G, Mehta JL. Aortic stenosis: is it simply a degenerative process or an active atherosclerotic process? Clin Cardiol. 2005;28(3):111-4. 10. Nordestgaard BG

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Sperm DNA Integrity Test and Assisted Reproductive Technology (Art) Outcome

fertilization and embryo development. Hum Reprod. 2002; 17:990-8. 13. Saleh RA, Agarwal A, Nelson DR, Nada EA, El-Tonsy MH, Alvarez G, et al. Increased sperm nuclear DNA damage in normozoospermic infertile men: a prospective study. Fertil Steril. 2002;78:313-8. 14. Spano M, Bonde JP, Hjollund HI, Kolstad HA, Cordelli E, Leter G. Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertil Steril. 2000;73:43-50. 15. Zini A, Bielecki R, Phang D, Zenzes MT. Correlations between two markers

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Langerhans-Cell Histiocytoses - Epidemiology, Classification, Clinical Features, Diagnosis, Complications, Treatment and Prognosis

; 2009. 7. Kissenpfennig A, A'l't-Yahia S, Clair-Moninot V, Stossel H, Badell E, Bordat Y, et al. Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function. Mol Cell Biol. 2005;25(l):88-99. 8. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7:19-30. 9. Berres ML, Merad M, Allen CE. Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X? Br J Haematol. 2015; 169

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