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-patient relationships, allowing more time for human interaction when care is boosted by digital technologies that better individualize diagnostics and patient monitoring ( 1 ).
The use of digital technologies and mobile health (mHealth) applications is driven by the continuous development of connected devices, sensors and digital health applications. Digital technologies participate in precision medicine with potential impact on prevention, early diagnosis and monitoring of chronic diseases. An increasing evidence shows that mHealth technologies decreases the number of disease
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Karel Crha, Pavel Ventruba, Jana Žáková, Michal Ješeta, Radovan Pilka, Jan Vodička and Igor Crha
Microbial colonization significantly contributes to physiological function of many organs and its alterations can be accompanied with many serious pathological conditions. At present, there is a lot of knowledge and evidence which changes the long-term concept on sterile environment in uterine cavity.
Microbial colonization of endometrium was proved as well as its metabolic activity that contributes to production of substances important for pregnancy development and detoxification of xenobiotics [ 1 , 2 ]. Recent studies have analysed relation
Katarzyna Stefańska, Ievgenia Kocherova, Sandra Knap, Magdalena Kulus, Piotr Celichowski and Michal Jeseta
Pre-implantation embryo development is affected by oviductal epithelial cells as well. Studies conducted by White et al. clearly show that the coculture of primary porcine OECs with early embryos promotes blastocyst cleavage [ 3 ]. Similar results were obtained in sheep, mouse, cattle and human, which suggests that OECs provide an optimal environment for early embryo development [ 1 ].
Since the oviduct and OECs undoubtedly play major part in early aspects of pregnancy development, from providing an optimal environment for gametes and embryos to supporting
Agata Chamier-Gliszczyńska, Sandra Kałużna, Katarzyna Stefańska, Piotr Celichowski, Paweł Antosik, Dorota Bukowska, Małgorzata Bruska, Jana Zakova, Marie Machatkova, Michal Jeseta and Michał Nowicki
The mammalian oocytes formation begins in the ovary during the fetal development. In the perinatal period the primary oocyte is surrounded by the epithelial cells which form a primordial follicle [ 1 ]. After oocytes start maturation, their nuclei–germinal vesicles (GV) break down and chromosomes condense [ 2 ]. Each oocyte in the ovary is arrested by inhibitory signals in the prophase I during the first meiotic division [ 3 ]. This arrest occurs after chromosome pairing and crossing-over process between parental chromosomes [ 4 ] The factors
Ievgeniia Kocherova, Maciej Brązert, Patrycja Sujka-Kordowska, Aneta Konwerska, Magdalena Kulus, Błażej Chermuła, Piotr Celichowski, Hanna Piotrowska-Kempisty, Paweł Antosik, Dorota Bukowska, Małgorzata Bruska, Leszek Pawelczyk, Maciej Zabel, Michał Nowicki, Bartosz Kempisty and Michal Jeseta
]. Free radical-induced damage caused by oxidative stress plays a significant role in the pathogenesis of many diseases [ 4 , 5 , 6 , 7 ].
Oxygen metabolism has an important role in the normal functioning of reproductive system and in the pathogenesis of infertility in females. Oxidative stress seems to be responsible for the initiation or development of reproductive organ diseases, including polycystic ovary syndrome, endometriosis, preeclampsia, etc. [ 8 , 9 , 10 ]. However, disturbances in oxygen metabolism may take place outside of pathological conditions