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Burnout syndrome among ICU personnel

pshychological burnout among nursing staff. Psycology&Health. 2001; 16:583-594. 5. Swider B, Zimmerman R. Born to burnout: A meta-analytic path model of personality, job burnout, and work outcomes. Journal of Vocational Behaviour. 2010; 76:487-506. 6. Maslach C, Leiter MP. Early predictors of job burnout and engagement. Journal of Applied Psychology. 2008; 93:498-512. 7. Bauer J, Stamm A, et al. Correlation between burnout syndrome and psychological and psychosomatic symptoms among teachers. International Archives of Occupational and Environmental Health

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Chemotherapy induced liver toxicity in children with malignant diseases

Irodalom 1. Grigorian A., O’Brien C.B. – Hepatotoxicity Secondary to Chemotherapy. Journal of Clinical and Translational Hepatology, 2014, 2:95-102. 2. Stirnimann G., Kessebohm K., Lauterburg B. – Liver injury caused by drugs: an update. Swiss Med Wkly 2010, 140:w13080. 3. Xie C., Yue L.J., Ding H., et al. – Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene. Zhongguo Dang Dai Er Ke Za Zhi, 2014, 16(5):499-503. 4

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Current aspects of polycystic ovary syndrome I: definition, pathophysiology, clinical manifestations, diagnosis and complications

, Robin G, Leroy M, Pigny P, et al. Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries. Hum. Reprod. 2011;26:3123–9. 46. Tal R, Seifer DB, Khanimov M, Malter HE, Grazi R V, Leader B. Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes. Am. J. Obstet. Gynecol. Elsevier Inc; 2014;1–8. 47. Cassar S, Teede

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Vitamin D in Critically Ill Patients - From Molecular Damage Interactions to Clinical Outcomes Benefits. When, Why, How?


Vitamin D - „the sunshine vitamin” is essential for the good functioning of the human body. The most important forms of the vitamin D are the vitamin D2 and the vitamin D3, both biologically inactived. Vitamin D can come from: diet or nutritiv suplimentts and skin. The activation of vitamin D is effect in two steps to the physiologically active 1,25-dihydroxyvitamin D [1,25(OH)2D]. The biological actions of Vitamin D involve regulation of gene expression at the transcriptional level and are mediated through binding to a Vitamin D Receptor (VDR). Vitamin D has multiple roles: hormonale/ nonhormonale, skeletale/nonscheletale, genomice/nongenomice. Interesting is inversely corelation between Vitamin D and total body fat (BMI) and correlation between Vitamin D and cognitive impairment, especially Alzheimer Disease or delirium during hospitalisation. The curent recomandations regarding the supplying with Vitamin D are different for regions of the globe, also differ depending on the baseline serum Vitamin D and on the desired effect. So, potential nonskeletal effects occur at levels >30ng/ml, above 50-75ng/ml, serum level who should become the target of the supplementation. The loading dose should be considered perioperatively for rapid effects. In conclusion, Vitamin D is more than just a vitamin. It is a substance with multiple roles in body’s economy, and in recent years there has been an interest in the relation be tween vitamin D deficiency and obesity or cognitive impairment. The majority of the data supports association, not causation, of low vitamin D levels. In other words, much of data does not clearly support the idea that vitamin D supplementation in a patient with low vitamin D levels reduces the risk of these diseases. But, the supplimentation is very easy and no harm might be done.

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Nutrition challenges in polytrauma patients. New trends in energy expenditure measurements

. Papurica M, Rogobete AF, Sandesc D, Dumache R, Nartita R, Sarandan M, et al. Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas. Mol Biol Int. 2015;2015:238586. 17. Bedreag OH, Rogobete AF, Sandesc D, Cradigati CA, Sarandan M, Popovici SE, et al. Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy and Clinical Aspects. A Retrospective Single Center Study. 2016;(10):1747–59. 18. Papurica M

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Association of Coronary Wall Shear Stress With Atheromatous Plaque Vulnerability: A Systematic Review

28. Sun Z. Coronary CT angiography: Beyond morphological stenosis analysis. World J Cardiol 2013;5:444-452 29. Zaromytidou M, Siasos G, Coskun AU, Lucier M, Antoniadis AP, Papafaklis MI, et al. Intravascular hemodynamics and coronary artery disease: New insights and clinical implications. Hellenic J Cardiol 2016;57:389- 400 30. Sun Z, Chaichana T. Computational fluid dynamic analysis of calcified coronary plaques: correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen

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