Jiangeng Han, Xin Wang, Weiyi Chai, Kunbin Liu and Chen Wang
investigated and analyzed the correlation between the prevalence of invasive fungal infection and BGL in critically ill ICU patients and presented some conclusions.
1 Materials and methods
1.1 Clinical data
From August 2015 to August 2017, 108 critically ill ICU patients in our hospital were enrolled as study subjects (58 males and 50 females). The age range was 21–68 years, with an average age of 54.2 ± 3.2 years. The patients had the following underlying health problems: cerebral vascular accidents (35 cases), pulmonary disease (30 cases), advanced cancers (24 cases
Mingxing Su, Congsong Sun, Haiying Wang, Chunyu Yuan, Ruixia Guo, Yajie Liang, Chao Liu and Qiang Wang
treated with 0.1, 1.0, and 10.0 mg/mL ATO solution, respectively. Taking the last exposure time as the experimental starting point, blood (5 mL) was collected via the abdominal aorta into EDTA-K vacuum blood collection tubes at 6, 12, 24, 48, and 72 h and analyzed using a fully automated blood analyzer.
Analysis was conducted using SPSS 18.0. The results were expressed as the mean ± standard deviation. Groups were compared by one-way analysis of variance (ANOVA), followed by the Student–Newman–Keuls (SNK) post-hoc test. Pearson correlation
. Study on the correlation between HPV16 and Helicobacter pylori infection in gastric. Modern Journal of Oncology, 2009, 17(6): 1012-1016.
14 Ma H, Cai S, Li Y, et al . Detection of HPV gene in colorectal cancer. Chinese Journal of Clinical Oncology, 2003, 30(2): 16-18, 22.
15 Cornall AM, Roberts JM, Garland SM, et al . Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with “low-risk” HPV genotypes 6 and 11. Int J Cancer, 2013, 133(9): 2253-2258.
16 Varnai AD, Bollmann M, Griefingholt H, et al . HPV
Wen-jie Zhang, Zhao-xia Li, Deng-hai Mi, Jing Li, Jian-jun Yang, Wei-wu Mao, Yan-xuan Gong and Yan Qu
and clinical correlations in Chinese patients. Liver 1999; 19(5):411-417.
7. Sugiyama M, Mizokami M. Hepatitis B virus genotype and the mutation related to clinical outcome. Nihon Rinsho 2011; 69(4):350-355.
8. Shi YH. Correlation between hepatitis B virus genotypes and clinical outcomes. Jpn J Infect Dis 2012; 65(6):476-482.
9. Chen Y, Yu D, Zhang W, Qiu C, Xiang G, Dai W, et al. HBV subgenotype C2 infection, A1762T/G1764A mutations may contribute to hepatocellular carcinoma with cirrhosis in southeast China. Iran J
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Scully M. Yarranton H. Liesner R. Cavenagh J. Hunt
infection and its clinical progression in male Han-Taiwanese. PLoS One 2014 9 6 e99724
 Zhang Y, Zhao F, Lan L, Qin Z., Jun L., Correlation of HLA － DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection, Int. J. Clin. Exp. Med., 2015, 8(4), 6067. 26131205 Zhang Y Zhao F Lan L Qin Z. Jun L. Correlation of HLA － DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection Int. J. Clin. Exp. Med 2015 8 4 6067
 Al-Qahtani A.A., Al-Anazi M.R., Abdo A.A., Sanai F.M., Al-Hamoudi W., Alswat K.A., et al
] divided the patients into two groups, with group A as gastric Hp-positive patients and group B as gastric Hp-negative patients. The same method was used to detect oral Hp in the two groups, and the results showed that the oral positive rate was higher in group A than in group B. This result indicated that oral Hp and stomach Hp had certain correlation. Assumpção et al . [ 12 ] studied a total of 99 patients with dyspepsia and used PCR to compare and analyze Hp in the oral cavity and gastric mucosa of the same patient. The Hp genotype in the oral cavity was found to be
vaginal infectious diseases. This result has been highly valued by clinicians in recent years [ 1 , 2 ]. This review summarizes the correlation between vaginal microecology and vaginal infection during the gestation period by reviewing recent clinical literature to improve the understanding of clinicians and perfect the treatment scheme for vaginal microecological-related diseases during pregnancy.
Summary of vaginal microecology
The vagina is a cavity that connects directly to the outside world and consists of a layer of microbes on its surface
The association of gene polymorphism and susceptibility to hepatocellular carcinoma (HCC) has been widely studied in recent years. Gene mutations are closely related to HCC. Understanding and measuring the gene mutations are useful to reduce the incidence of HCC and improve its prognosis.
Shen-rong Hu, Yong-tao Huai, Chuan-ying Pan, Chu-zhao Lei, Hong Chen and Xian-yong Lan
Objective To investigate the 23 bp and 12 bp insertion/deletion (indel) mutations within the bovine prion protein (PRNP) gene in Chinese dairy cows, and to detect the associations of two indel mutations with BSE susceptibility and milk performance.
Methods Based on bovine PRNP gene sequence, two pairs of primers for testing the 23 bp and 12 bp indel mutations were designed. The PCR amplification and agarose electrophoresis were carried out to distinguish the different genotypes within the mutations. Moreover, based on previous data from other cattle breeds and present genotypic and allelic frequencies of two indels mutations in this study, the corrections between the two indel mutations and BSE susceptibility were tested, as well as the relationships between the mutations and milk performance traits were analyzed in this study based on the statistical analyses.
Results In the analyzed Chinese Holstein population, the frequencies of two “del” alleles in 23 bp and 12 bp indel muations were more frequent. The frequency of haplotype of 23del-12del was higher than those of 23del- 12ins and 23ins-12del. From the estimated r2 and D’ values, two indel polymorphisms were linked strongly in the Holstein population (D’ = 57.5%, r2 = 0.257). Compared with the BSE-affected cattle populations from the reported data, the significant differences of genotypic and allelic frequencies were found among present Holstein and some BSE-affected populations (P < 0.05 or P < 0.01). Similarly, there were significant frequency distribution differences of genotypes and alleles among Chinese Holstein and several previous reported healthy dairy cattle (P < 0.05 or P < 0.01). Moreover, association of genotype and combined genotypes of two indel polymorphisms with milk performance and resistant mastitis traits were analyzed in Holstein population, but no significant differences were found (P > 0.05).
Conclusions These observations revealed that the influence of two indel mutations within the bovine PRNP gene on BSE depended on the breed and they did not affect the milk production traits, which layed the foundation for future selection of resistant animals, and for improving health conditions for dairy breeding against BSE in China.