Zsuzsanna Jeremiás, Katalin Makó, Norbert Szekeres, Emese Rapolti, Imre Benedek and Theodora Benedek
femoral levels in a middle-aged population. Int J Cardiovasc Imaging . 2013;29(3):589-599.
13. Kirhmajer MV, Banfic L, Vojkovic M, Strozzi M, Bulum J, Miovski Z. Correlation of femoral intima-media thickness and the severity of coronary artery disease. Angiology . 2011;62(2):134-139.
14. van der Meer IM, Iglesias del Sol A, Hak AE, Bots ML, Hofman A, Witteman JC. Risk factors for progression of atherosclerosis measured at multiple sites in the arterial tree: the Rotterdam Study. Stroke . 2003 Oct;34(10):2374-9.
Alexandru Vlasa, Lia Yero Eremie, Luminița Lazăr, Anamaria Bud, Mariana Păcurar, Eugen Bud and Carmen Biriș
1. Alfuriji S, Alhazmi N, Alhamlan N, et al The Effect of Orthodontic Therapy on Periodontal Health. International Journal of Dentistry . 2014;2014:6. Article ID 585048
2. Scheibel PC, Ramos AL, Iwaki LCV, Micheletti KR. Analysis of correlation between initial alveolar bone density and apical root resorption after 12 months of orthodontic treatment without extraction. Dental Press Journal of Orthodontics . 2014;19(5):97-102.
3. Jung Y-H, Cho B-H. External root resorption after orthodontic treatment: a study of contributing factors
S, Muthu MS. Oral findings of Down syndrome children in Chennai city, India. Indian J Dent Research . 2008;9:230-235.
12. Diz P, Limere J. Correlation between dental maturation and chronological age in patients with cerebral palsy, mental retardation and Down syndrome. Research Developmental Disabilities . 2011;32:808-817.
13. Leroy R, Cecere S, Lesaffre E, Declerck D. Variability in permanent tooth emergence sequences in Flemish children. Eur J Oral Science . 2008;116:11-17.
Irinel Panainte, Victor Suciu and Krisztina-Ildikó Mártha
zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet. 2011;89:595-606.
7. Andria LM, Leite LP, Prevatte TM, King LB. Correlation of the Cranial Base Angle and Its Components with Other Dental/Skeletal Variables and Treatment Time. Angle Orthod. 2004;74:361-366.
8. Bacon W, Eiller V, Hildwein M, Dubois G. The cranial base in subjects with dental and skeletal Class II. Eur J Orthod. 1992;14:224-228.
9. Arntsen T, Sonnesen L. Cervical vertebral column morphology related to craniofacial
Tiberiu Nyulas, Theodora Benedek, Claudia Matei, István Kovács, Monica Chiţu, Szillamér Korodi and Imre Benedek
Introduction: The present study aims to demonstrate the role of acute impairment of regional contractility, as assessed by 3D echocardiography, in predicting LV remodeling in post acute myocardial infarction (AMI) patients.
Methods: We enrolled in the study a number of 48 subjects with AMI who underwent primary PCI followed by optimum medical therapy. In all these cases we followed the correlation between the amplitude of ventricular remodeling at 6 months postinfarction and regional contractility in the immediate postinfarction period, as assessed by 3D echo parameters at baseline: regional index of contraction amplitude (RICA) and the index of contraction amplitude (ICA). Positive remodeling (PR) was defined as an increase in LV end-diastolic global volume with >15% compared with baseline.
Results: Patients with positive remodeling (PR) presented at baseline a significantly lower ejection fraction (44.75% versus 49.95%, p = 0.009), associated with a higher end-systolic volume (80.34 ml vs. 70.63 ml, p = 0.02) and lower values for index of contraction amplitude — ICA (3.05 vs. 3.53, p = 0.01) and for regional index of contraction amplitude — RICA (1.38 vs. 2.78, p <0.0001), in comparison with the patients who did not experience ventricular remodeling. RICA achieved the best statistical significance for predicting the development of LV remodeling during the evolution of the disease. For RICA, the ROC curve using logistic analysis showed an area under the curve (AUC) of 0.88, highly significant (p = 0.0001).
Conclusions: Impairment of regional contractility is associated with development of LV remodeling to a more significant extent than the global impairment of ventricular contractility.
Simona Cernea, Ciprian Blendea, Andrada Larisa Roiban and Theodora Benedek
Aim: The aim of the study was to evaluate the correlation between renal function and heart function/echocardiographic parameters and epicardial adipose tissue thickness (EATT), respectively.
Material and methods: Fifty patients with type 2 diabetes (T2D) were included in this study. Several laboratory parameters were obtained (HbA1c, fasting blood glucose, LDL-cholesterol, creatinine) and eGFR was calculated. Anthropometric measurements were performed (weight, waist and hip circumferences, 4 skinfolds, based on which % body fat was calculated). Patients underwent echocardiographic assessment to evaluate structural and functional parameters, including EATT. Left ventricular mass (LVM) was calculated and the geometric changes of the left ventricle were evaluated.
Results: Forty-six per cent of the patients had a LV ejection fraction (EF) <55% and 34% had diastolic dysfunction. There were no significant differences between the three eGFR groups with regards to metabolic parameters, but LVEF was lower (53.0 ± 0.8%, 54.4 ± 2.4%, and 55.2 ± 1.5%, respectively) and EATT was higher (11.0 ± 1.0 mm, 8.58 ± 2.2 mm, and 7.63 ± 2.6 mm, respectively) with a lower eGFR (p = 0.04). More patients with eGFR <90 mL/min/1.73 m2 had cardiac hypertrophy compared with those with eGFR ≥90 mL/min/1.73 m2 (p = 0.04). EATT correlated positively with several anthropometric parameters, e.g. weight (r = 0.309, 95% CI: 0.022 to 0.549, p = 0.03), BMI (r = 0.398, 95% CI: 0.123 to 0.616, p = 0.004), and negatively with LVEF (r = −0.496, 95% CI: −0.687 to −0.242, p = 0.0003) and eGFR (r = −0.293, 95% CI: −0.531 to −0.013, p = 0.04). In patients with LVEF <55% vs. ≥55%, the EATT was significantly higher (9.5 ± 1.99 mm vs. 7.33 ± 2.37 mm, p = 0.013).
Conclusion: In patients with T2D decreased renal function was associated with lower LVEF and higher EATT. EATT was also higher in patients with reduced LVEF.
Roxana Hodaş, Sorin Pop, Diana Opincariu, Nora Rat, Laura Jani, Alexandra Stanescu, Edvin Benedek, Imre Benedek, Theodora Benedek and Monica Chitu
; comparison with manual assesment and correlation with coronary artery disease. J Cardiovasc Comput Tomogr . 2014;8:215-221.
14. Coppini G, Favilla R, Marraccini P, et al. Quantification of epicardial fat by cardiac CT imaging. Open Med Inform J . 2010;4:124-135.
15. Mahabadi AA, Lehmann N, Kalsch H, et al. Association pf Epicardial Adipose Tissue With Progression of Coronary Artery Calcification Is More Pronounced in the Early Phase of Atherosclerosis. JACC Cardiovasc Imaging . 2014;7(9):909-16.
16. Iwasaki K, Matsumoto T, Aono H, et al. Relationship
Theodora Benedek, Ioana Rodean, Mihaela Ratiu, Nora Rat, Lia Yero Eremie, Carmen Biriș, Luminița Lazăr, Mariana Păcurar and Imre Benedek
, de Oliveira Izar MC. High-Sensitivity C-Reactive Protein and Cardiovascular Disease Across Countries and Ethnicities”. Clinics (Sao Paulo). 2016;71:235-242. doi: 10.6061/clinics/2016(04)11.
24. Assadpour Piranfar M. The Correlation between High-Sensitivity C-Reactive Protein (hsCRP) Serum Levels and Severity of Coronary Atherosclerosis. Int Cardiovasc Res J. 2014;8:6-8.
25. van Soesta G, Marcub L, Boumac BE, Regardet E. Intravascular imaging for characterization of coronary atherosclerosis. Current Opinion in Biomedical Engineering. 2017;3:1-12. doi
Alexandra Stănescu, Zsuzsanna Suciu, Nora Rat, Mirabela Morariu and Monica Chiţu
Coronary Angiography. Korean J Radiol. 2010;11:514–521. DOI: 10.3348/kjr.2010.11.5.514
13. La Grutta L, Runza G, Lo Re G, et al. Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography. Radiol Med. 2009;114(7):1024-1036. DOI: 10.1007/s11547-009-0446-y.
Theodora Benedek, Nora Rat, Roxana Hodas, Diana Opincariu, András Mester and Imre Benedek
, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine. 2005;29:251-255. doi: 10.1016/j.cyto.2004.11.002.
10. Hodas R, Pop S, Opincariu D, et al. Correlations Between Severity of Coronary Lesions and Epicardial Fat Volume in Patients with Coronary Artery Disease - a Multislice CTbased Study. Journal of Interdisciplinary Medicine. 2016;1:71-78. doi: 10.1515/jim-2016-0014.
11. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic