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Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

al. DW MRI at 3.0 T versus FDG PET/CT for detection of malignant pulmonary tumors. Int J Cancer 2014; 134: 606-11. 4. Li F, Yu T, Li W, Zhang C, Cao Y, Su D, et al. Correlation of apparent diffusion coefficient with histologic type and grade of lung cancer. Zhongguo Fei Ai Za Zhi 2012; 15: 646-51. 5. Xu L, Tian J, Liu Y, Li C. Accuracy of diffusion-weighted (DW) MRI with background signal suppression (MR-DWIBS) in diagnosis of mediastinal lymph node metastasis of nonsmall-cell lung cancer (NSCLC). J Magn Reson Imaging 2014; 40: 200

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LncRNA PVT1 promotes proliferation and invasion through enhancing Smad3 expression by sponging miR-140-5p in cervical cancer

-5p were significantly downregulated in cervical cancer cells. Inhibition of PVT1 significantly increased the expressions of miR-140-5p in cervical cancer cells. In addition, luciferase assay was further applied to determine the correlation between PVT1 and miR-140-5p. Our results revealed that miR-140-5p upregulation could significantly inhibit the luciferase activities of PVT1-WT but did not affect that of PVT1-MUT, indicating that PVT1 binds to miR-140-5p and regulate its function. To further, clarify the interaction of PVT1 and miR-140-5p during the progression

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Circulating serum sVCAM-1 concentration in advanced ovarian cancer patients: correlation with concentration in ascites

, Perrett CW. Angiogenesis in epithelian ovarian cancer. Mol Pathol 2002; 55: 348-59. 32. Garmy-Susini B, Jin H, Zhu Y, Sung RJ, Hwang R, Varner J. Integrin alpha4beta1- VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J Clin Invest 2005; 115: 1542-51. 33. Yamamoto S, Konishi I, Mandai M, Kuroda H, Komatsu T, Nanbu K, et al. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum

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Reply to comments on “State of the art in magnetic resonance imaging of hepatocellular carcinoma”: the role of DWI

focal nodular hyperplasia and HCC. 4 Furthermore, a few recent studies showed that there is a correlation between the histopathological grade and prognosis of HCC and DWI, demonstrating that significantly lower ADC values in poorly differentiated tumors with a shorter recurrence-free survival and a cut-off value of 1.175 x 10 -3 mm 2 /s to predict microvascular invasion. 5 , 6 Regarding Diffusion kurtosis imaging (DKI), we also recognize its current role in the evaluation of non-Gaussian water diffusion, providing better information in heterogeneous tissues such

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Relationship between sex hormones levels and 18F-FDG uptake by the ovaries in premenopausal woman

normal distribution, so they are presented as medians and interquartile range (IQR). The Mann–Whitney test was used to compare groups distinguished based on the menstrual phase. The Kruskal–Wallis test was used to compare ovarian 18 F-FDG uptake among groups distinguished based on weeks since onset of menstruation. If the Kruskal–Wallis test was significant, a post-hoc analysis was performed for pairwise comparisons of the subgroups. Spearman’s rank coefficient correlation test was used to examine the correlations between the ovary SUVs and levels of sex hormones

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Health-related quality of life in Croatian general population and multiple myeloma patients assessed by the EORTC QLQ-C30 and EORTC QLQ-MY20 questionnaires

half of the questions were answered. 19-21 To investigate if there is a correlation between EORTC QLQ-C30 and QLQ-MY20 scores, Pearson correlation coefficient calculations were performed. Statistical analysis Demographic characteristics were analysed as categorical variables and are represented in numbers and relative frequencies. Four age categories (40-49, 50-59, 60-69 and 70+) and six geographical regions were applied. The chi-square test was applied for determining the statistical significance of difference in demographical characteristics among groups of

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Comment on “State of the art in magnetic resonance imaging of hepatocellular carcinoma”: the role of DWI

chronic liver disease, since DWI can accurately detect HCC in patients with chronic liver disease regardless of the lesion size. The major limits of DWI are the different parameters used in DWI sequences, which may affect the results of ADC calculation. Several researches have evaluated the relationship between functional data by DWI and histological grade of HCC. Granata et al . 4 found that DWI could be used to predict the histological grade of HCC, showing a good correlation between ADC and grading, between perfusion fraction (fp) and grading, and between tissue

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The “question-mark” MR anatomy of the cervico-thoracic ganglia complex: can it help to avoid mistaking it for a malignant lesion on 68Ga-PSMA-11 PET/MR?

“mistakable”, potentially suspicious of malignancy, including lymph node metastasis. The non-specific shapes (wavy with small nodules, bent or unreliable to be assessed), were named “other”, and were also treated as not suspicious of malignancy. Statistical analysis Statistical calculations were performed using IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corporation (Released 2015). Basic descriptive statistics was calculated and subsequently the Kolmogorov-Smirnov tests, the Pearson’s r correlation and χ2 tests were performed. The significance

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Radiological findings of porcine liver after electrochemotherapy with bleomycin

investigation of other tissues, particularly tumor tissue is required, because it is reasonable to expect that radiologic findings after ECT of hepatic neoplasia differ from radiologic findings after ECT of healthy liver due to differences in vascular and extracellular spaces. Furthermore, relatively small number of animals has been investigated, which prevented further statistical analyses and a better correlation between different groups. Conclusions Radiologic findings after EP/ECT of porcine liver did not show clinically significant damage to large liver vessels and

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KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer – practical implications for the clinician

), they all play a significant role in the process, facilitating selection of the right treatment for the right patient. The aim of this review is to provide clinicians with an update on the particular features of these biomarkers. The correlations between demographic, clinical, pathological and molecular characteristics of KRAS, NRAS, BRAF, HER2 and MSI and patient outcome will be presented, together with the role of these assessments in determining mCRC prognosis and treatment personalization. This paper shows the impact of such biomarkers analyzing the results of

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