An Verdoodt, Patrick M. Honore, Rita Jacobs, Elisabeth De Waele, Viola Van Gorp, Jouke De Regt and Herbert D. Spapen
the kidneys via cholesterol-related and -unrelated mechanisms, resulting in potential acute and long-term benefit on the renal function.[ 2 , 3 ]
We reviewed the literature on statin use for prevention and treatment of various acute or chronic kidney(-related) disorders. Statins are highlighted as a novel therapeutic approach with reference to potential beneficial or harmful effects.
Arguments in favor of statin use
Prevention of acute kidney injury (AKI) after cardiac surgery
AKI complicating cardiac surgery is often multifactorial, leaving the precise
Sebastien Redant, Jacques Devriendt, Ilaria Botta, Rachid Attou, David De Bels, Patrick M. Honoré and Charalampos Pierrakos
] Another argument was that thermodilution did not allow the distinction between hydrostatic and inflammatory edema. [ 9 ] The study by Kushimoto refuted this last argument by introducing the PVPI. [ 11 ] Before the Berlin criteria were available, the definition of ARDS did include the PAOP value measured by pulmonary arterial catheters (Swan-Ganz catheter). This was even more invasive, expensive and methodologically limited than transpulmonary thermodilution. [ 9 ] Pulmonary edema now includes cardiogenic pulmonary edema, ARDS (at risk, moderate or severe), and a
the AAA between EPA and DHA groups. Similar arguments have been presented by Meital et al . [ 2 ] and suggested that inflammation plays a key role in the pathogenesis of AAA, and EPA and DHA are beneficial in the animal models of AAA in view of their anti-inflammatory actions. It was also suggested [ 2 ] that anti-inflammatory products of EPA and DHA, such as resolvins, protectins and maresins, may have a role in this beneficial action.
Pufas and their metabolites, angiotensin-II, AA and AAA
These results reported by Yoshihara et al . [ 1 ] and
. One could argue that the rates of recurrent disease, biochemical disease, metastasis, persistent disease, or death, which were reported as not statistically different, are an indication that both treatments are ineffective and that one should administer higher prescribed activities of I-131. To take this argument further, if one compares the administration of 30 mCi of I-131 to no treatment with I-131 and demonstrates that the outcomes are the same, would one conclude that they are equally effective or would one conclude that 30 mCi is not effective at all? Both are
not entirely clear based on information currently available; however, an article by Jasanoff et al . [ 3 ] posted on the US National Academy of Science’s website as part of the promotion for the recent NAS/ NAM International Summit meeting on gene editing contains arguments that support the US government’s position on the regulation of genome science research and the moratorium it proposes. The article was also published in the NAS’s Issues in Science and Technology publication, and even though gene editing is a controversial subject, the NAS did not post or
sectional and epidemiologic data support the intuitive argument that PVTs which are completely occlusive and have greater extension ( i . e ., mesenteric involvement) are associated with higher morbidity, increased technical difficulty during liver transplantation, and increased mortality after liver transplantation.[ 5 , 6 ] More intriguingly, a highly criticized but randomized controlled trial in patients at high risk for PVT using enoxaparin in prevention of PVT over the course of a year showed that low molecular weight heparin (LMWH) was not only highly effective at
surgical treatment without need for total thyroidectomy and its inherent greater surgical risk. Thus, a thyroid nodule with an indeterminate cytopathology (AUS, FLUS) or even one that is definitely PTC but only 1 cm or less, would not demand total thyroidectomy, and lobectomy alone would suffice according to the current ATA Guidelines. The arguments raised for these EFVPTC tumors are similar to those for papillary microcarcinoma, and the guidelines also allow for not administering radioiodine for ablation of these low-risk tumors.
A non-aggressive treatment approach is
is described on Wikipedia as follows: “Propaganda is a form of communication that is aimed towards influencing the attitude of a community toward some cause or position by presenting only one side of an argument. Propaganda is usually repeated and dispersed over a wide variety of media in order to create the chosen result in audience attitudes.
As opposed to impartially providing information, propaganda, in its most basic sense, presents information primarily to influence an audience. Propaganda often presents facts selectively (thus possibly lying by omission