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Single Fraction versus Multiple Fraction Radiotherapy for treatment of painful bone metastases: A Prospective Study; Mansoura experience

1998; 40:915-21. [16] Haddad P, Wong RK, Pond GR, Soban F, Williams D, McLean M, et al. Factors influencing the use of single vs. multiple fractions of palliative radiotherapy for bone metastases: A 5-year review. Clin Oncol (R Coll Radiol) 2005; 17:430-4. [17] Chow E, Lutz S, Beyene J. A single fraction for all, or an argument for fractionation tailored to fit the needs of each individual patient with bone metastases? Int J Radiat Oncol Biol Phys 2003; 55:565-7. [18] Majumder D, Chatterjee D, Bandyopadhyay A, et al

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BRCA1/2 associated cancer susceptibility: a clinical overview

. Recently, M.C. King, a leading investigator of the identification of BRCA1 and 2 genes, at a provocative keynote lecture, while receiving the 2014 Lasker award, addressed the proposal for a population-wide BRCA testing [ 36 ]. Despite the significant controversies, risks and problems associated with such a public health strategy, an extensive discussion was kicked off due to that proposal. An important argument is the fact that approximately one-fourth of mutation carriers have no relevant family history, thus having no possibility of being warned that they are

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Radiotherapy in palliative treatment of painful bone metastases

al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 1999; 52: 101-9. Tong D, Gillick, Hendrickson FR. The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group. Cancer 1982; 50: 893-9. Chow E, Lutz S, Beyene J. A single fraction for all, or an argument for fractionation tailored to fit the needs of each individual patient with bone

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Pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head with venous resection

1371 1375 [2] Marangoni G, O’Sullivan A, Faraj W Heaton W, Rela M. Pancreatectomy with synchronous vascular resection-An argument in favor. Surgeon 2012; 10 : 102-6 10.1016/j.surge.2011.12.001 Marangoni G O’sullivan A Faraj W Heaton W Rela M Pancreatectomy with synchronous vascular resection-An argument in favor Surgeon 2012 10 102 106 [3] Katz MH, Pisters PW, Evans DB, Sun CC, Lee JE, Fleming JB, et al. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg 2008; 206 : 833-46 10.1016/j.jamcollsurg.2007

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Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

arguments in an old discussion. Acta Neurochir (Wien) 2011; 153 : 1211-8. 10.1007/s00701-011-1001-x Stummer W van den Bent MJ Westphal M. Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion Acta Neurochir (Wien) 2011 153 1211 8 10.1007/s00701-011-1001-x 5 Almenawer SA, Badhiwala JH, Alhazzani W, Greenspoon J, Farrokhyar F, Yarascavitch B, et al. Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis. Neuro

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Infarct-core CT perfusion parameters in predicting post-thrombolysis hemorrhagic transformation of acute ischemic stroke

possible interpatient variability of absolute CTPPs, encouraging the use of relative CTPPs instead. 21 , 22 The above arguments prompted us to focus on analyzing relative CTPPs of the infarct core, with the full knowledge that there might currently be no point of reference to compare our results directly. We found additional reasoning for an infarct-core approach in the fact that our attempts at free-hand whole-infarct designation with image segmentation to eliminate structures that were irrelevant for CTP ( e.g ., large vessels and sulci) proved futile in many cases

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Voluntary deep inspiration breath-hold reduces the heart dose without compromising the target volume coverage during radiotherapy for left-sided breast cancer

. Therefore, cardiac sparing afforded by V-DIBH technique is likely to be an underestimation of the actual sparing effect. This can be regarded as a supporting argument for the confirmation of our study hypothesis. The inter-observer (intra-approach) variation of cardiac contouring was comparable between the FB and V-DIBH scans as demonstrated by similar relative standard deviation of around 15%. Consequently, the impact of contouring variation on uncertainties of the DVH parameters was similar for both simulation approaches, making our results clinically relevant. Our V

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Retrospection of the effect of hydroxyurea treatment in patients with sickle cell disease

as arginine, and molecular oxygen [ 27 ]. Further, this free-radical gas molecule is produced in vitro by the oxidation HU by heme groups [ 28 ]. Significant increase in NO-derived species after an oral dose of HU indicates NO release from HU in vivo [ 29 ]. These observations provide a strong argument for the participation of NO in the mechanism of HbF induction by HU [ 30 ]. Further, NO can promote the modification of cysteine 93 in the hemoglobin b-chain, by nitrosation [ 31 ] or transnitrosation reactions, to form glutathionyl hemoglobin [ 32 ], which inhibits

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