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. Shimada, “Shikonin induces an anti tumor effect on murine mammary cancer via p38 dependent apoptosis”, Oncology reports, Vol. 41, 2020-2026, 2019. DOI: org/10.3892/or.2019.6966. [4] R. Thakur, R. Trivedi, N. Rastogi, M. Singh, and D.P. Mishra, “Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer”, Scientific reports, Vol. 5, 10194, 2015. DOI: 10.1038/srep10194. [5] K.H. Lin, M.Y. Huang, W.C. Cheng, S.C. Wang, S.H. Fang, H.P. Tu, C.C. Su, Y.L. Hung, P.L. Liu, C.S. Chen, and Y.T. Wang

-induced apoptosis of cultured rat Sertoli cells, Reproductive Toxicology, 17 (4). 457-464.

present in the lower male genital tract: a five-year retrospective study. European Journal of Contraception & Reproductive Health Care, 16:47-53, 2011. EGGERT-KRUSE, W., ROHR, G., STROCK, W., POHL, S., SCHWALBACH, B., RUNNEBAUM, B.: Anaerobes in ejaculates of sub fertile men. Human Reproduction Update 1:462-478, 1995. FISHER, K., PHILLIPS, C.: The ecology, epidemiology and virulence of Enterococcus. Microbiology, 155:1749-1757, 2009. FRACZEK, M., HRYHOROWICZ, M., GACZARZEWICZ, D., SZUMALA-KAKOL, A., KOLANOWSKI, TJ., BEUTIN L., KURPISZC M.: Can apoptosis and necrosis

selected computer assisted sperm analysis parameters and bull fertility. Veterinarski arhiv, 87(2):129-137. Erickson L., Kroet T., Anzar M., 2016 - Relationship between sperm apoptosis and bull fertility: in vivo and in vitro studies. Reproduction, fertility and development, 28(9):1369-1375 Hoflack G., Opsomer G., Rijsselaere T., Van Soom A., Maes D., de Kruif A., Duchateau L., 2007 - Comparison of computer-assisted sperm motility analysis parameters in semen from Belgian Blue and Holstein-Friesian bulls. Reproduction in domestic animals, 42(2):153-161 Kathiravan P

. Infect. Dis., 14(12)1870‒1874,2008. doi: 10.3201/eid1412.080591. SANCHEZ-CORDON, P.J., NUNEZ, A., SALGUERO, F.J., PEDRERA, M., DE MARCO, M.F., GOMEZ-VILLAMANDOS, J.C.: Lymphocyte apoptosis and thrombocytopenia in spleen during classical swine fever: role of macrophages and cytokines. Vet. Pathol., 42(4)477‒488,2005. SÁNCHEZ-VIZCAÍNO, J. M., ARIAS NEIRA, M.: African swine fever virus. In: Diseases of Swine (J.J. Zimmerman, L.A. Karriker, A. Ramirez, K.J. Schwartz, G.W. Stevenson, eds.), Iowa State Press, Ames, Iowa, pp. 501‒24,2012. SÁNCHEZ-VIZCAÍNO, J.M., MUR, L

. LUTTRELL, W.E., GILES, C.B.: Toxic tips: osmium tetroxide. J Chem Health Saf., 14(5)40-41, 2007. MAILLET, A., YADAV, S., LOO, Y.L., SACHAPHIBULKIJ, K., PERVAIZ, S.: A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma. Cell Death Dis., 4(6)e653, 2013. MAKAROVSKY, I., MARKEL, G., HOFFMAN, A., SCHEIN, O., FINKELSTIEN, A., BROSH-NISSIMOV, T., TASHMA, Z., DUSHNITSKY, T., EISENKRAFT, A.: Osmium tetroxide: a new kind of weapon. Isr Med Assoc J., 9(10)750-752, 2007. MARQUET, P., FRANCOIS, B., VIGNON, P., LACHATRE, G

impairment and proliferation enhancement in cultured HPRT deficient neuroblastoma cells, a neuronal model of LND, has also been proposed [ 73 ]. Intrastriatal hypoxanthine administration to 60-day-old rats altered neuroenergetic parameters, resulting in ATP depletion and mitochondrial dysfunction and cell death by apoptosis, suggesting that these processes may be associated, at least in part, with neurological symptoms found in LND patients [ 74 ]. Deficit of other purine compounds due to HPRT defect is controversial, and altered nucleotide concentrations have been