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. Shimada, “Shikonin induces an anti tumor effect on murine mammary cancer via p38 dependent apoptosis”, Oncology reports, Vol. 41, 2020-2026, 2019. DOI: org/10.3892/or.2019.6966. [4] R. Thakur, R. Trivedi, N. Rastogi, M. Singh, and D.P. Mishra, “Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer”, Scientific reports, Vol. 5, 10194, 2015. DOI: 10.1038/srep10194. [5] K.H. Lin, M.Y. Huang, W.C. Cheng, S.C. Wang, S.H. Fang, H.P. Tu, C.C. Su, Y.L. Hung, P.L. Liu, C.S. Chen, and Y.T. Wang

impairment and proliferation enhancement in cultured HPRT deficient neuroblastoma cells, a neuronal model of LND, has also been proposed [ 73 ]. Intrastriatal hypoxanthine administration to 60-day-old rats altered neuroenergetic parameters, resulting in ATP depletion and mitochondrial dysfunction and cell death by apoptosis, suggesting that these processes may be associated, at least in part, with neurological symptoms found in LND patients [ 74 ]. Deficit of other purine compounds due to HPRT defect is controversial, and altered nucleotide concentrations have been