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Left main stenting induced flow disturbances on ascending aorta and aortic arch

. Noticeably, higher WSS within the ascending aorta have been suspected to be involved in aortic aneurysm and dissection. [ 4 , 5 ] The aim of our study is to investigate, by means of computation fluid dynamic analysis (CFD), the presence and potential impact of turbulences induced by ostial LM stenting, not only in the LM but also within the ascending aorta and arch. Methods Construction of the virtual model For the computational domain analysis, we reconstructed the ascending aortic arch from the plane of the aortic valve to the left subclavian artery. Both

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Heterogeneity of aortic smooth muscle cells: A determinant for regional characteristics of thoracic aortic aneurysms?

thoracic aorta is composed of four distinct regions: aortic root, ascending aorta, aortic arch, and descending portion. [ 2 ] Of note, 60% of TAAs impact the aortic root and/or the ascending aorta in human. [ 3 ] For example, TAAs in Marfan syndrome and Ehlers-Danlos syndrome occur most often in the aortic root. [ 4 , 5 , 6 ] TAAs in Loeys-Dietz syndrome and Turner syndrome preferentially form in both the aortic root and the ascending aorta. [ 7 , 8 , 9 , 10 ] Aortic aneurysms in patients with bicuspid aortic valve are most commonly reported in the ascending

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Aortic aneurysm

aging of the population, the rise in the number of smokers, the introduction of screening programs, and improved diagnostic tools. The disorder is more common in men than in women, with prevalence rates estimated at 1.3–8.9% in men and 1.0–2.2% in women. [ 1 ] However, thoracic aortic aneurysms (TAAs) have an estimated incidence of at least 5-10 per 100,000 person-years. [ 2 ] According to location, TAAs are classified into aortic root or ascending aortic aneurysms, which are most common (≈60%), followed by aneurysms of the descending aorta (≈35%) and aortic arch

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