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Hajar Negahdar, Seyed Reza Hosseini, Hadi Parsian, Farzan Kheirkhah, Abbas Mosapour, Soraya Khafri and Asefeh Hagh Haghighi
AD – Alzheimer’s disease
MCI – mild cognitive impairment
OS – oxidative stress
Aβ – amyloid-β
MDA – malondialdehyde
TBARS – Thiobarbituric Acid Reactive Substances
FRAP – Ferric Reduction Antioxidant Power
Hcy – Homocysteine
MMSE – Mini-Mental State Examination
MCI I – mild cognitive impairment stage I
MCI II – mild cognitive impairment stage II and III or moderate to severe cognitive impairment
AHAP – Amirkola Health and Aging Project
1. BURNS A, ZAUDIG M. Mild cognitive impairment in older people
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Based on the high prevalence, diabetes mellitus (DM) is considered as a worldwide problem. More than 8.3 % of the world population is suffering from this disease. One of the causing factors of this disease can be the absence or imbalance of trace, essential elements. It can cause collapses of antioxidant defence and glucose intolerance. It plays a role in the pathogenesis and progression to diabetes mellitus. This review focuses on chromium, copper, selenium, vanadium, and zinc. Many studies deal with these elements but there is variability in opinions. Insulin-mimetic activity and ability to control the concentrations of blood glucose were confirmed. However, these effects were of more importance in patients with prediabetes. In patients with prediabetes, due to the supplementation of selected trace elements, it is possible to normalize the blood glucose level and prevent the development of diabetes mellitus. The importance of supplementation was confirmed for chromium and zinc. The supplementation of vanadium has a positive effect on the normalization of glycaemia but it is necessary to control the level as it can have toxic effects during long-term treatment. Conversely, higher copper concentrations in the body adversely affect patients and chelation therapy is needed. Selenium must be kept in the standard concentration and regular control of the concentration in the body is necessary. For this reason it is necessary to continue with analysis and the creation of new methodologies that could unify the view on the issue.
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Shahinul Alam, Mohammad Jahid Hasan, Md. Abdullah Saeed Khan, Mahabubul Alam and Nazmul Hasan
Hardy T Anstee QM Day CP Nonalcoholic fatty liver disease: New treatments Curr Opin Gastroenterol 2015 31 175 83
24 Hadi HE, Vettor R, Rossato M. Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? Antioxidants 2018;7:12. 10.3390/antiox7010012
Hadi HE Vettor R Rossato M Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? Antioxidants 2018 7 12
25 Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, Vitamin E, or
Ludovico Abenavoli, Natasa Milic, Francesco Luzza, Luigi Boccuto and Antonino De Lorenzo
protective effects are related to the high concentration of antioxidants in compounds of this diet. Since the 1950s, Ancel Keys and his co-workers have been studying the Mediterranean diet effects on health, and they found that Greek people, especially belonging to the island of Crete, had the longest life expectancy in the world until the 1960s, followed by the people of Southern Italy, Spain and France.[ 16 ] These data were confirmed by subsequent studies on the elderly population in Greece and other European Countries, and showed that the Mediterranean dietary pattern