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Selected factors influencing angiogenesis and hematopoietic niche

Hematopoiesis is a complex process, which takes place in the bone marrow microenvironment in a so-called hematopoietic niche. Within the hematopoietic niche, osteoblastic, and vascular parts are distinguished. The osteoblastic part of the HSC niche is responsible for maintenance of dormant, resting HSC, while active, dividing HSCs are located mainly near endothelial cells (EC) in the vascular part of the niche [ 1 ]. The close relation of the hematopoietic cells with stromal cells is mediated by interactions of adhesive molecules with respective ligands

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