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Evaluation of long-term antibody response and cross-serotype reaction in ducks immunised with recombinant Riemerella anatipestifer outer membrane protein A and CpG ODN

–511. 10.1586/erv.10.174 21506647 Bode C. Zhao G. Steinhagen F. Kinjo T. Klinman D.M. CpG DNA as a vaccine adjuvant Expert Rev Vaccines 2011 10 499 511 2 Calderon-nieva D.: Improving the delivery and immunogenicity of an inhalable CpG-ODN DNA vaccine by bio-adhesive gemini nanoparticles in neonatal chickens. UWSpace 2018. Calderon-nieva D. Improving the delivery and immunogenicity of an inhalable CpG-ODN DNA vaccine by bio-adhesive gemini nanoparticles in neonatal chickens UWSpace 2018 http

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Research progress in urinary tract infection and its therapeutic drugs



The objective of this study was to understand the pathological mechanism and therapeutic progress in the study of urinary tract infections to provide references for clinical diagnosis and identification and development of therapeutic drugs.


We summarized the types, pathological mechanisms, and therapeutic drugs for urinary tract infections on the basis of recent publications on these infections, both domestic and abroad.

Results and conclusions

Urinary tract infection is mainly caused by pathogenic bacterial infection and treated by targeting bacterial adhesion, bacterial toxin, protease, urease, and siderophores, as well as using pili as vaccines and small-molecule drugs. Vaccines that target bacterial adhesion can block well the interaction between pathogens and the body, thereby reducing the incidence of urinary tract infections. The clinical efficacy of vaccines targeting bacterial toxins and proteases needs further evaluation. Vaccines targeting iron carriers retard disease progression and attenuate bacterial colonization. Urease-targeted small-molecule drugs exhibit certain curative effects and serious side effects. Small pili-targeted drugs can prevent and treat urinary tract infections by blocking the colonization and invasion of pathogens in animal models of urinary tract infections on the bladder. Adhesive FimH antibodies have entered Phase I clinical trials. However, pilicides, mannosides, and vaccines that target pili, iron carriers, and other virulence factors are still in the experimental or preclinical stages of research.

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Pathogenicity of FtsK mutant of avian pathogenic Escherichia coli

References 1. Begg K.J., Dewar S.J., Donachie W.D.: A new Escherichia coli cell division gene, ftsK. J Bacteriol 1995, 177, 6211-6222. 2. Bigot S., Sivanathan V., Possoz C., Barre F.X., Cornet F.: FtsK, a literate chromosome segregation machine. Mol Microbiol 2007, 64, 1434-1441. 3. Chen X., Gao S., Wang X.Q., Jiao X.A., Liu X.F.: Identification of APEC genes expressed in vivo by selective capture of transcribed sequences. Acta Microbiol Sin 2007, 47, 407-412. 4. Dho M., Lafont J.P.: Adhesive

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Comparison of clinical, biomechanical, and histopathological effects of various suture techniques on repair of tendon rupture by using autograft

.M.: Comparative evaluation of the tendon-bone interface contact pressure in different single-versus double-row suture anchor repair tecnhiques. Knee Surg Sports Traumatol Arthosc 2009, 17, 1466–1472. 7. Chan A.P.H., Lo C.K., Lam H.Y., Fung K.Y.: Unusual traumatic triceps tendon avulsion rupture:a word of caution. Hong Kong Med J 2009, 15, 294–296. 8. Cihan M., Özaydın İ.: Experimental tenorraphy with fibrin adhesive (Tiseel) in sheep. Kafkas Üniv Vet Fak Derg 1999, 5, 103–112. 9. Deny H.R.: Surgery of the stifle joint. In: A Guide to Canine Orthopaedic

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Contribution of Pili of S. Pneumoniae in the Onset of Meningitis

adhesive clusters of Rrg A. PLoS Pathogens , 4, e1000026. 11. Hilleringmann, M., Ringler, P., Müller, S. A., De Angelis, G., Rappuoli, R., Ferlenghi, I., et al., 2009: Molecular architecture of Streptococcus pneumoniae TIGR4 pili. The EMBO Journal , 28, 3921—3930. . 12. Honda, E., Yanagawa, R., 1978: Pili-mediated attachment of Corynebacterium renale to mucous membrane of urinary bladder of mice. Am. J. Vet. Res. , 39, 155—158. 13. Iovino, F., Hammarlöf, D. L., Garriss, G., Brovall, S

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An experimental in-vitro study to evaluate the anti-helicobacter activity of Glycyrrhetinic acid

infection in children. Rev Romana Med Lab, 2009; 15(2):61-8. 20. Hirschl AM, Makristathis A. Methods to detect Helicobacter pylori:from culture to molecular biology. Helicobacter. 2007; Suppl 2:6-11. DOI: 10.1111/j.1523-5378.2007.00560.x 21. O’Mahony R, Al-Khtheeri H, Weerasekera D, Fernando N, Vaira D, Holton J, et al. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World Journal of Gastroenterology 2005; 11:7499-507. DOI: 10.3748/wjg.v11.i47.7499 22. Siddique O, Ovalle A, Siddique AS, Moss SF

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Basic and clinical research progress in acute lung injury/acute respiratory distress syndrome

associated with leukocyte and red blood cell migration to various transmitters in the alveoli. Inflammatory mediators and signaling pathways may be involved in endothelial and alveolar epithelial cell permeability changes [ 21 ]. Vascular endothelial cell cadherin (VE-cadherin) and adhesive junction proteins play a key role in maintaining the integrity of endothelial cell barriers [ 22 ]. In the ALI/ARDS study, researchers have been extensively aiming to use molecular methods to reverse pulmonary edema caused by increased vascular permeability. A major treatment strategy

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