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Perforacja jelit jako powikłanie chemioterapii ostrej białaczki limfoblastycznej u dzieci – opis dwóch przypadków

acute lymphoblastic leukemia. Med Sci Monit 2015;21:1656–61. 10.12659/MSM.893142 Yang L Yu L Chen X Hu Y Wang B Clinical analysis of adverse drug reactions between vincristine and triazoles in children with acute lymphoblastic leukemia Med Sci Monit 2015 21 1656 – 61 [11] Ceppi F, Langlois-Pelletier C, Gagné V, et al. Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia. Pharmacogenomics 2014;15(8):1105–16. 10.2217/pgs.14.68 Ceppi F Langlois-Pelletier C Gagné V et al

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The prognostic value of mean platelet volume in cancer patients

the patients without VTE (median 7.2 fL, p = 0.034). Patients with baseline MPV 6.8 fL or below more often developed VTE compared to patients with higher MPV values (19% vs. 5.5%, p = 0.0244). Of the HL patients, in both the univariate and multivariate models, the patients with baseline low MPV levels had an above twofold increased risk of VTE development [ 29 ]. There are also reports about the prognostic role of platelet parameters in acute lymphoblastic leukemia (ALL) in pediatric patients [ 30 , 31 ]. ALL is the most common type of cancer

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Wykorzystanie metod cytogenetycznych i molekularnych w ocenie statusu genetycznego oraz przebieg leczenia u pacjenta z rzadką dziecięcą postacią ALL BCR-ABL1-like spowodowaną translokacją t(9;10)(q34;q22)

. Piśmiennictwo References [1] Moorman AV. The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Rev 2012;26(3):123–35. 22436535 10.1016/j.blre.2012.01.001 Moorman AV The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia Blood Rev 2012 26 3 123 35 [2] Mrózek K, Harper DP, Aplan PD. Cytogenetics and molecular genetics of acute lymphoblastic leukemia. Hematol Oncol Clin North Am 2009;23(5):991–1010. 19825449 10.1016/j

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Infectious complications in children and adults with hematological malignancies

]. Fig. 1 Overall cumulative incidence of infections in pediatric hematology and oncology (PHO) and pediatric hematopoietic stem cell transplantation (HCT) settings between 2012 and 2017: (A and B) including possible, probable, and proven IFD; (C and D) including probable and proven but not possible IFD Infections in pediatric hematology and oncology setting Acute lymphoblastic leukemia (ALL) The analysis included 1363 patients, with newly diagnosed ALL (2012–2017). The patients received therapy according to the ALL IC-BFM 2002 and 2009 (Intercontinental

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Szczepienia ochronne u dzieci w trakcie i po leczeniu onkologicznym oraz w wybranych chorobach hematologicznych: rekomendacje Polskiego Towarzystwa Onkologii i Hematologii Dziecięcej

Wstęp Nowotwory u dzieci zaliczane są do chorób rzadkich. Według najnowszych danych w Polsce rozpowszechnienie chorób nowotworowych w populacji pediatrycznej ocenia się na około 151 : 1 mln dzieci w ciągu roku. Pięcioletnie całkowite przeżycie dla dzieci leczonych z powodu najczęstszego pediatrycznego rozrostu, ostrej białaczki limfoblastycznej ( acute lymphoblastic leukemia – ALL), według protokołu ALLIC 2010 wynosi 86% [ 1 ]. Jeszcze lepsze rezultaty osiągane są w leczeniu chłoniaka Hodgkina u dzieci, gdzie całkowite przeżycie sięga 98% [ 2 ]. Wyleczalność

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Szczepienia ochronne u dorosłych chorych na nowotwory hematologiczne oraz u chorych z asplenią – zalecenia PTHiT i sekcji do spraw zakażeń PALG

Orenstein WA Ofifit PA Vaccine 6th ed Saunders, Philadelphia 2013 [56] Saghafian-Hedengren S, Söderström I, Sverremark-Ekström E, et al. Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses. Blood Rev 2018;32:71–80. 10.1016/j.blre.2017.08.009 Saghafian-Hedengren S Söderström I Sverremark-Ekström E Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma

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Prognostic value of soluble angiotensin II receptor 1 and soluble angiotensin converting enzyme (CD 143) in patients with acute leukemia

accumulation of blast cells in the bone marrow and peripheral blood [ 12 ]. Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by the accumulation of lymphoblasts and it may be B or T lineages and the first attempt at classifying ALL was the French-American-British (FAB) morphological criteria that divided ALL into 3 subtypes (L1, L2 and L3) based on cell size, cytoplasm, nucleoli, vacuolation and basophilia. In 1997, the World Health Organization proposed a composite classification in an attempt to account for morphology and cytogenetic profile of the

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Study of CD25 expression on leukemic cells: a prognostic factor in acute myeloid leukemia

receptor induces T-cell proliferation and differentiation [ 8 ]. Recent research has described CD25 as a poor prognostic factor in acute lymphoblastic leukemia [ 9 ]. Moreover, in AML, previously published data from small retrospective studies have suggested an unfavorable impact of CD25 [ 10 , 11 ]. Therefore, our aim was to evaluate the expression of CD25 in adult Egyptian patients with newly diagnosed AML and thereafter study its impact on prognosis. 2 Subjects and methods The current study was conducted with 50 newly diagnosed adult AML patients before

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Opieka ginekologiczna po transplantacji komórek krwiotwórczych – zalecenia na podstawie piśmiennictwa i własnych doświadczeń

preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update J Clin Oncol 2013 31 19 2500 – 10 10.1200/JCO.2013.49.2678 [24] Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood 2010;116(16):2908–14. 10.1182/blood-2010-01-265751 Dolmans MM Marinescu C Saussoy P Van Langendonckt A Amorim C Donnez J Reimplantation of cryopreserved ovarian tissue from

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Statystyka w praktyce hematologicznej

younger adults with acute myeloid leukemia in first remission: a phase 2 Cancer and Leukemia Group B Study (CALGB 10503). Leukemia 2017; 31(1):34–39. 10.1038/leu.2016.252 Blum W Sanford BL Klisovic R Maintenance therapy with decitabine in younger adults with acute myeloid leukemia in first remission: a phase 2 Cancer and Leukemia Group B Study (CALGB 10503) Leukemia 2017 31 1 34 39 [13] Desjonquères A, Chevallier P, Thomas X, et al. Acute lymphoblastic leukemia relapsing after first-line pediatric-inspired therapy: a retrospective GRAALL study

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