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Zhi-Jian Li, Xing-Ling Sui, Xue-Bo Yang and Wen Sun
LSCs. TAL1 was one of the top 5 DEGs in experiment 2 (CD34+ isolated from BMs), which belonged to the basic helix–loop–helix (HLH) family of TFs that bind as heterodimers with theE2A and HEB/HTF4 gene products to a nucleotide sequence motif termed the E-box [ 24 ]. It plays a key role in controlling the development of primitive and definitive hematopoiesis during mouse development [ 25 ]. It is also a critical regulator of hematopoietic and vascular development and is misexpressed in the majority of patients with T-cell acutelymphoblasticleukemia (ALL) [ 26