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Gingival health in children in the different phases of acute lymphoblastic leukemia

analysis and periodontal status in children with atopy. I nterv Med Appl Sci. 2017;9(4):199-203. 5. Arigbede AO, Babatope BO, Bamidele MK: Periodontitis and systemic diseases: A literature review. J Indian Soc Periodontol. 2012;16(4):487-91. 6. Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group. J Clin Oncol. 2012;30(14):1663-69. 7. Lauritano D, Petruzzi M, Fumagalli T, Giacomello MS

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Evaluation of the combined effects of doxorubicin and bortezomib on the human acute lymphoblastic leukemia cell line

Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw . 2017;15:230-69. 10. open access: 01.09.2018 11. Terwilliger T, Abdul-Hay M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer Journal . 2017;7:e577. 12. Identifier: NCT00440726 13. open access: 01.09.2018 14

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Biochemical aspects of KB-28 compound on physically loaded study subjects


In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.

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A comparison of caspase 3 expression in the endocrine and exocrine parts of the pancreas after cladribine application according to the "leukemic" schema

induced by paclitaxel and carboplatin therapy in an ovarian cancer patient. Eur J Gynaecol Oncol., 37, 286, 2016. 26. Sigal D. et al.: Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood, 116, 2884, 2010. 27. Sikorska-Fic B. et al.: Acute pancreatitis during chemotherapy of acute lymphoblastic leukaemia complicated with pseudocyst. Med Wieku Rozwoj., 12(4 Pt 2),1051, 2008. 28. Soreide K., Sund M.: Epidemiological - molecular evidence of metabolic reprogramming on proliferation, autophagy

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