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development [ 25 ]. It is also a critical regulator of hematopoietic and vascular development and is misexpressed in the majority of patients with T-cell acute lymphoblastic leukemia (ALL) [ 26 ]. Tumor-specific activation of the TAL1 gene occurs in ~25% of patients with T-cell ALL [ 27 ]. Thus, TAL1 might be closely connected with the development and progression of AML. RIF metric was used to identify critical TFs from gene-expression data. The top 5 ranked TFs in experiment 4 were TP53, HOXA5, HLF, MECOM, and NR3C1. Moreover, TP53 was one of the core genes in the PPI

HIV B-cell epitopes Autoimmun. Rev 2008 7 291 296 [53] Polito, A., Polimeno, R., Kanduc, D., Peptide sharing between Parvovirus B19 and DNA methylating/histone modifying enzymes: a potential link to childhood acute lymphoblastic leukemia, Int. J. Pediatr. Child Health, 2017, 5, 29-39. Polito A. Polimeno R. Kanduc D. Peptide sharing between Parvovirus B19 and DNA methylating/histone modifying enzymes: a potential link to childhood acute lymphoblastic leukemia Int. J. Pediatr. Child Health 2017 5 29 39 [54] Kanduc, D., Epstein-Barr virus, immunodeficiency, and cancer