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Acute Lymphoblastic Leukemia after previously treated, relapsed Chronic Lymphocytic Leukemia: A Case Report


We present the case of a 71-year-old woman diagnosed with chronic lymphocytic leukemia who received multiple chemotherapeutic lines and evolved to acute lymphoblastic leukemia. The patient was Rai stage 0 at the time of the diagnosis and was monitored for almost 9 years. After that, the disease progressed and the patient began chemotherapy (fludarabine/cyclophosphamide combination), obtained complete remission and relapsed one year later after finishing treatment. She received multiple therapeutic regimens, accompanied by multiple infectious complications. After 8 years of evolution since she started chemotherapy, bone marrow aspirate and immunophenotyping revealed acute lymphoblastic leukemia. The occurrence of acute leukemia in CLL is rare and may arise from the same clone; however, most cases appear after patients have received chemotherapy, suggesting that they are therapy-related.

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Acute Lymphocytic Leukemia in Adults. Pathologic Features and Prognosis

, LAZARUS HM, FRANKLIN IM, LITZOW MR, CIOBANU N, PRENTICE HG, DURRANT J, TALLMAN MS & GOLDSTONE AH. Induction therapy for adults with acute lymphoblastic leukaemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood. 2005; 106, 3760-3767. 5. JACOB M ROWE. Prognostic factors in adult acute lymphoblastic leukaemia. British Journal of Haematology, 2010, 150, 389-405. 6. MOORMAN AV, CHILTON L, WILKINSON J, et al. A population-based cytogenetic study of adults with acute lymphoblastic leukemia

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Preterm birth among women living within 600 meters of high voltage overhead Power Lines: a case-control study

, DESSYPRIS N, SKALKIDIS Y, et al. Electrical power lines and childhood leukemia: a study from Greece.Int J Cancer. 1997; 73(3):345-8. 11. SOHRABI MR, TARJOMAN T, ABADI A, YAVARI P. Living near overhead high voltage transmission power lines as a risk factor for childhood acute lymphoblastic leukemia: a case-control study. Asian Pac J Cancer Prev. 2010; 11(2):423-7. 12. SWANSON J. Childhood cancer in relation to distance from high-voltage power lines in England and Wales: a case-control study. J Radiol Prot. 2005;2 5

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